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Medicine capable of treating refractory insomnia, and preparation method of medicine

A stubborn and drug-based technology, applied in the field of medicine, can solve problems such as limited therapeutic effect and patients' inability to get off the drug to sleep normally, and achieve the effect of alleviating patients' symptoms and improving sleep quality

Inactive Publication Date: 2020-02-07
THE INT PEACE MATERNITY & CHILD HEALTH HOSPITAL OF CHINA WELFARE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the therapeutic effect of these drugs is limited, but it will make patients unable to get off the drugs to sleep normally.

Method used

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  • Medicine capable of treating refractory insomnia, and preparation method of medicine
  • Medicine capable of treating refractory insomnia, and preparation method of medicine
  • Medicine capable of treating refractory insomnia, and preparation method of medicine

Examples

Experimental program
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Effect test

Embodiment 1

[0020] A medicine for treating intractable insomnia, which is composed of the following components by mass: 1500 parts of propofol, 3 parts of scopolamine hydrobromide; 100 parts of croscarmellose sodium; 1000 parts of mannitol; 100 parts Low-substituted hydroxypropyl cellulose; 10 parts magnesium stearate.

[0021] Its preparation process is as follows:

[0022] S1: Take 150 mg of propofol, 0.3 mg of scopolamine hydrobromide, 10 mg of croscarmellose sodium, 100 mg of mannitol, and 10 mg of low-substituted hydroxypropyl cellulose prepared as claimed in claim 2 or 3. , magnesium stearate 10mg and appropriate amount of starch for later use;

[0023] S2: Pass the propofol, scopolamine hydrobromide, and croscarmellose sodium obtained in S1 through a 100-mesh sieve and mix well;

[0024] S3: put the mixture obtained in S2 into the starch slurry to make wet granules, keep dry and control the water content to be less than 3%;

[0025] S4: Mix the wet granules obtained in S3 with t...

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PUM

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Abstract

The invention discloses a medicine capable of treating refractory insomnia, and a preparation method of the medicine. The medicine comprises the following ingredients: propofol, hyoscine hydrobromide,croscarmellose sodium, mannitol, low-substituted hydroxypropyl cellulose and magnesium stearate. Specifically, the medicine is optimally a sublingual tablet, and the medicine can effectively alleviate the symptoms of patients and improve the sleep and living quality of a patient by aiming at the inducement of the refractory insomnia.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine for treating intractable insomnia and a preparation method of the medicine for treating intractable insomnia. Background technique [0002] In the classification of insomnia, insomnia is a common disease, and intractable insomnia is a serious state of insomnia, compared with secondary insomnia, its treatment is more difficult. The specific clinical manifestations are: the patient has difficulty falling asleep and maintaining sleep, and is prone to feeling tired during the day. Long-term sleep deprivation can seriously cause changes in perception, such as visual field changes, hallucinations, decreased immune function, decreased digestive and sexual functions, decreased memory, irritable temper, and personality changes. It can also induce high blood pressure and coronary heart disease. , stroke, diabetes, women cause dry skin, menstrual disorders and other...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/46A61K9/20A61K47/38A61K47/26A61K31/05A61P25/20
CPCA61K9/2054A61K9/2018A61K9/006A61K31/05A61K31/46A61P25/20A61K2300/00
Inventor 杨泽勇李启芳操锋
Owner THE INT PEACE MATERNITY & CHILD HEALTH HOSPITAL OF CHINA WELFARE INST
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