Temperature-sensitive gel for promoting vagina tightness and preparation method and application thereof

Abstract

The invention provides a temperature-sensitive gel for promoting vagina tightness and a preparation method and application thereof. According to the technical scheme, a temperature-sensitive blank gelcapable of performing a reversible sol-gel conversion with temperature change is used as a matrix at first, and then functional components are added into the matrix. The temperature-sensitive gel comprises poloxamer, chitosan, chlorhexidine gluconate, hyaluronic acid and jasmine flower essential oil in specific proportions, and anti-bacterium drugs, anti-fungus drugs, anti-mold drugs, anti-mycoplasma drugs and other components can be further added on the basis; the temperature-sensitive gel is a slow-release preparation, the pH value of the temperature-sensitive gel accords with the vaginal environment, the temperature-sensitive gel is in a liquid state when the temperature is 28 DEG C or below, so that the liquid-state temperature-sensitive gel can permeate into deep folds of uterus andvagina to kill pathogens; the liquid-state temperature-sensitive gel is gelated to be covered on the infected part after the gel contacts with body temperature for 3-5 minutes, so that the temperature-sensitive gel is not easy to overflow, and the action time and action concentration of the drugs on the drug receiving site are effectively ensured. In addition, the temperature-sensitive gel has good anti-inflammatory and bactericidal effects and an exact vaginal tightening effect.

Description

technical field [0001] The invention relates to the technical field of external gynecological drugs, in particular to a temperature-sensitive gel for promoting vaginal firming, its preparation method and application. Background technique [0002] Women's vagina is naturally warm and humid, with a lot of secretions, and it is easy to breed microorganisms. Therefore, vaginal care is an important means to ensure women's health. Among vaginal care products, lotions, suppositories, and traditional gels are the most widely used dosage forms; among them, lotions are liquid preparations. Although they can wash the vagina, the lotions are easy to overflow outside the body, resulting in too short local action time. The bactericidal effect is poor; and frequent use of a large amount of lotion to clean the reproductive tract will destroy the natural protection mechanism of the vagina, destroy the ecological balance in the vagina, and easily produce negative effects. Suppositories have ...

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the technical defects of the prior art, and provides a temperature-sensitive gel for promoting vaginal firming, its preparation method and application, so as to solve the problem that conventional vaginal gels have to be improved in the treatment of female vaginitis in the prior art. technical problem

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