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A kind of novel nanopesticide preparation and preparation method thereof

A technology of nano-pesticides and preparations, applied in botany equipment and methods, fungicides, insecticides, etc., can solve the problems of difficult industrialization, high equipment requirements, and multi-process equipment, and achieve particle stability and equipment requirements. Low, wide application prospects

Active Publication Date: 2021-03-30
SHANDONG AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Abamectin nano-pesticides prepared by existing methods have extremely high requirements on equipment and need to add fillers. A lot of equipment is used and the process is complicated, so it is difficult to realize industrialization

Method used

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  • A kind of novel nanopesticide preparation and preparation method thereof
  • A kind of novel nanopesticide preparation and preparation method thereof
  • A kind of novel nanopesticide preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: Preparation of novel nanopesticide preparation

[0036] (1) Get the Abamectin of 0.005g, be dissolved in 10mL isopropanol, make the Abamectin-isopropanol solution for subsequent use;

[0037] (2) Dissolve 1.0 mg of α-lactalbumin in 2 mL of deionized water, stir in a water bath at 50°C for 10 minutes, and obtain an aqueous solution of α-lactalbumin;

[0038] (3) α-lactalbumin aqueous solution is added dropwise in the abamectin-isopropanol solution, wherein the volume ratio of α-lactalbumin aqueous solution and avermectin-isopropanol solution is 1:50, Stir magnetically at 400 rpm for 10 minutes to obtain α-lactalbumin-abamectin nanoparticle emulsion, then place the emulsion at -20°C for 10 minutes to cool, take out the emulsion, and ultrasonically emulsify for 1 minute to obtain a nanoemulsion with uniform particle size;

[0039] (4) The isopropanol in the emulsion was removed by rotary evaporation to obtain an aqueous nanoparticle solution, which was freez...

Embodiment 2

[0043] Embodiment 2: Preparation of novel nanopesticide preparation

[0044] (1) get the Abamectin of 0.04g, be dissolved in 15mL isopropanol, make the Abamectin-isopropanol solution for subsequent use;

[0045] (2) Dissolve 1.0 mg of α-lactalbumin in 2 mL of deionized water, stir in a water bath at 50°C for 10 minutes, and obtain an aqueous solution of α-lactalbumin;

[0046](3) α-lactalbumin aqueous solution is added dropwise in the abamectin-isopropanol solution, wherein the volume ratio of α-lactalbumin aqueous solution and avermectin-isopropanol solution is 1:5, Stir magnetically at 900 rpm for 20 minutes to obtain α-lactalbumin-abamectin nanoparticle emulsion, then place the emulsion at -20°C to cool for 10 minutes, take out the emulsion, and ultrasonically emulsify for 2 minutes to obtain a nanoemulsion with uniform particle size;

[0047] (4) The isopropanol in the emulsion was removed by rotary evaporation to obtain an aqueous nanoparticle solution, which was freeze-...

Embodiment 3

[0048] Embodiment 3: Preparation of novel nanopesticide preparation

[0049] (1) get the Abamectin of 0.04g, be dissolved in 15mL isopropanol, make the Abamectin-isopropanol solution for subsequent use;

[0050] (2) Dissolve 5.0 mg of α-lactalbumin in 5 mL of deionized water, stir in a water bath at 50°C for 10 minutes, and obtain an aqueous solution of α-lactalbumin;

[0051] (3) the α-lactalbumin aqueous solution is added dropwise in the abamectin-isopropanol solution, wherein the volume ratio of the α-lactalbumin aqueous solution and the avermectin-isopropanol solution is 1:25, Stir magnetically at 1000 rpm for 30 minutes to obtain α-lactalbumin-abamectin nanoparticle emulsion, then place the emulsion at -20°C to cool for 30 minutes, take out the emulsion, and ultrasonically emulsify for 2 minutes to obtain a nanoemulsion with uniform particle size;

[0052] (4) The isopropanol in the emulsion was removed by rotary evaporation to obtain an aqueous nanoparticle solution, wh...

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Abstract

The invention discloses a novel nano pesticide preparation and a preparing method thereof. The preparation method comprises the following specific steps: (1) dissolving abamectin in an organic solventto prepare an abamectin-organic solvent solution for standby application; (2) dissolving alpha-whey protein in deionized water, and heating and stirring to obtain an alpha-whey protein aqueous solution; (3) dropwise adding the alpha-whey protein aqueous solution prepared in the step (2) into the abamectin-organic solvent solution prepared in the step (1), and stirring to obtain an alpha-whey protein-abamectin nanoparticle emulsion; (4) cooling the alpha-whey protein-abamectin nanoparticle emulsion prepared in the step (3), and carrying out ultrasonic emulsification to obtain a nano-emulsion with uniform particle size; and (5) removing the organic solvent in the emulsion, and carrying out freeze drying to obtain the nano pesticide preparation. The novel nano pesticide preparation preparedby the invention is large in drug loading capacity and strong in slow release capacity, avoids photolysis of abamectin, reduces the application times of pesticides, and realizes reduction of the pesticides.

Description

technical field [0001] The invention relates to the technical field of pesticide preparations, in particular to a novel nanopesticide preparation and a preparation method thereof. Background technique [0002] Avermectin is a sixteen-membered macrolide compound isolated from the fermentation broth of Streptomyces avermitilis isolated from soil samples by the Kitasato Research Institute of Japan. It has broad-spectrum, high-efficiency, and low-residue Features, often used as insecticides, fungicides, nematocides, and have stomach poisoning and contact killing effects on Coleoptera, Lepidoptera and other pests. Abamectin, as a nerve agent, strengthens the conductivity of chloride ions through glutamate-gated Cl- channels, and induces the release of a large amount of γ-aminobutyric acid (GABA). GABA has an inhibitory effect on the nerve conduction of arthropods. The target organism is paralyzed, paralyzed and dies. This channel only exists in insects and other invertebrates, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/90A01N25/22A01N25/12A01P3/00A01P1/00A01P5/00A01P7/04
CPCA01N25/12A01N25/22A01N43/90
Inventor 周成刚苏陈禹季英超刘彦雪李子坤曹晟涵
Owner SHANDONG AGRICULTURAL UNIVERSITY