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Shapable artificial bone compound material and preparation method thereof

A composite material and artificial bone technology, applied in the field of biomedical composite materials, can solve the problems of leaving a large number of gaps, not being able to use normally, being unable to be flexible, convenient and free plasticity, etc.

Active Publication Date: 2020-02-18
立心(深圳)医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, since the artificial bone material in Patent Document 1 needs to rely on water to obtain fluidity, it is easily washed away when injected in a clinical aqueous environment operation and cannot be used normally, while the material in Patent Document 2 is in the form of a blocky hard solid. It cannot be flexibly and conveniently freely plasticized, so it is inconvenient to use during surgery, and it is not easy to fill in the ingredients when filling bone defects and will leave a large number of gaps, which will affect bone growth

Method used

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  • Shapable artificial bone compound material and preparation method thereof
  • Shapable artificial bone compound material and preparation method thereof
  • Shapable artificial bone compound material and preparation method thereof

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preparation example Construction

[0071] Such as figure 2 As shown, the preparation method of the plastic artificial bone composite material 1 involved in the present disclosure may include the following steps: preparing a degradable polymer material 11, and dissolving the polymer material 11 in an organic solvent to obtain a polymer solution ( Step S10); adding inorganic particles 12 composed of calcium and phosphorus compounds into the polymer solution and mixing to obtain a mixture solution (step S20); drying the mixture solution and drying it in a vacuum to obtain a polymer material 11 and an artificial bone composite material 1 composed of inorganic particles 12, the average molecular weight of the polymer material 11 is 1000Da to 20000Da, and in the artificial bone composite material 1, the inorganic particles 12 are distributed in the polymer material 11, the artificial bone composite material 1 In the form of moldable plasticine (step S30). In addition, the average molecular weight of the polymer mat...

Embodiment 1】 to 【 Embodiment 22

[0091] Firstly, the monomers of each of Examples 1 to 22 were prepared. According to Table 1, the monomers of Examples 1 to 22 were prepared, and monomers having the average molecular weights and types shown in Table 1 were obtained. Next, the catalysts and initiators shown in Table 1 were respectively added to the monomers of Examples 1 to 22 to obtain a mixture containing the monomers. According to the reaction temperature and reaction time shown in Table 1, the mixture was heated to a predetermined reaction temperature and reacted for a predetermined time to obtain the degradable polymer materials of various examples of Examples 1 to 22.

[0092] Next, take the degradable polymer material of each embodiment (embodiment 1 to embodiment 22), and prepare the sample solution of each embodiment (embodiment 1 to embodiment 22) according to the ratio of 0.2g polymer material plus 1ml tetrahydrofuran , and then use tetrahydrofuran as mobile phase, and use polystyrene as molecular ...

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Abstract

The invention provides a shapable artificial bone compound material and a preparation method thereof. The shapable artificial bone compound material is characterized in that the shapable artificial bone compound material is a composition prepared through mixing a degradable polymeric material with inorganic granules distributed in the polymeric material, average molecular weight of the polymeric material is 1000Da-20000Da, the inorganic granules consist of calcium-phosphorus compounds, and besides, the artificial bone compound material presents the shape of shapable plasticene. The invention can provide the shapable artificial bone compound material which can be freely shaped and can be freely injected, and the preparation method of the shapable artificial bone compound material.

Description

technical field [0001] The disclosure belongs to the field of biomedical composite materials, in particular to a plastic artificial bone composite material and a preparation method thereof. Background technique [0002] Bone defect is a common disease, and various factors such as trauma, inflammation, bone disease, and surgery can cause bone tissue defect. The current method for repairing bone defects is to use artificial bone materials to repair them. Such artificial bone materials usually contain hydroxyapatite and other main inorganic components that make up human bones. [0003] The existing patent document 1 proposes an injectable artificial bone suspension and its preparation method. The artificial bone injection material is prepared by mixing hydroxyapatite, recombinant human bone morphogenetic protein-2, chitosan solution and heparin saline The disadvantage of this suspension is that the hydroxyapatite particles tend to precipitate in the liquid during storage, resu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/58A61L27/50
CPCA61L27/46A61L27/58A61L27/50A61L2400/06A61L2430/02A61L27/446A61L27/54A61L27/227A61L2300/404A61L2300/406A61L2300/414C08L67/04C08L89/00
Inventor 孙杨向冬凡小山赵金忠蒋佳燕晓宇王立人
Owner 立心(深圳)医疗器械有限公司
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