Preparation method of codonopsis pilosula sections

Abstract

The invention discloses a preparation method of codonopsis pilosula sections, which comprises the following steps: cleaning fresh codonopsis pilosula medicinal materials to remove impurities, cleaning, cutting the fresh codonopsis pilosula into sections, cleaning again, drying in a drying oven until the water content is lower than 10%, pulverizing the dried codonopsis pilosula, and drying again until the water content is lower than 5%, and obtaining codonopsis pilosula powder; and then performing supercritical extraction treatment on the codonopsis pilosula powder. A supercritical extraction technology is adopted for extracting the active ingredients of codonopsis pilosula, the extraction rate is remarkably superior to that of a traditional extraction technology, and the supercritical extraction technology has the advantages that extraction and separation can be completed at a time, the extraction efficiency is high, the active ingredients are well reserved, and no solvent is left. According to the supercritical extraction process disclosed by the invention, the components of an entrainer are optimized, so that the extraction rates of saccharides and glycosides are stable, and meanwhile, the extraction of alkaloid can be reduced.

Description

technical field

[0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method of Radix Codonopsis. Background technique

[0002] The source of Codonopsis Codonopsis is the dried roots of Codonopsis Codonopsis, Suhua Codonopsis, or Sichuan Codonopsis. Codonopsis is sweet in taste and flat in nature. There are invigorating vital energy, quenching thirst, invigorating the spleen and lungs, nourishing blood and promoting body fluid. Codonopsis pilosula has good medicinal value and is a common Chinese medicinal material used for both medicine and food.

[0003] Document 1: "Research Progress on Codonopsis Codonopsis Chemical Constituents and Pharmacological Actions", author Sun Zhenghua, etc. Document 1 discloses the main chemical components of Codonopsis pilosula, combined with other documents and prior art, it can be known that the active components of Codonopsis pilosula mainly include sugars, glycosides, steroid...

Examples

preparation example Construction

[0036] One embodiment of the present invention discloses a preparation method of Codonopsis Radix, comprising the following steps:

[0037] (1) Clean the fresh Codonopsis pilosula to remove impurities, then clean it, then cut the fresh Codonopsis pilosula into segments, wash it again and put it in an oven to dry until the water content is lower than 10%, then crush the dried Codonopsis pilosula again Dry until the moisture content is lower than 5%; obtain Codonopsis powder;

[0038] (2) Carry out supercritical extraction of Codonopsis Codonopsis powder with carbon dioxide, the extraction pressure of supercritical extraction is 25Mpa~35Mpa, the extraction temperature is 60°C~70°C, the flow rate of carbon dioxide is 1.5L / min~3L / min, and the extraction time is 2h~ 3h; entrainer flow rate is 0.5ml / min~1.5ml / min, entrainer is ethanol 60%~70% by weight, n-octyltrimethoxysilane 10%~20%, the balance is acetone; extraction is completed After obtaining Codonopsis pilosula extract;

[...

Embodiment 1

[0055] Embodiment 1: Preparation of Codonopsis Codonopsis Extract

[0056] (1), fresh Codonopsis pilosula is washed and cut off, and after cleaning again, it is placed in an oven and dried until the water content is 8%, then the dried Codonopsis pilosula is crushed and dried again until the water content is lower than 5%; then sieved, and 100-mesh powder is taken, Get Codonopsis powder;

[0057] (2), Codonopsis Codonopsis powder is subjected to carbon dioxide supercritical extraction, and the extraction pressure of supercritical extraction is 28Mpa, and extraction temperature is 68 ℃, and carbon dioxide flow rate is 2.2L / min, and extraction time is 2h; Entrainer flow rate is 1ml / min, entrains The agent is 65% by weight of ethanol, 15% of n-octyltrimethoxysilane, and the balance is 20% of acetone; that is, 65g of ethanol, 15g of n-octyltrimethoxysilane and 20g of acetone are prepared as entraining agents, and the extraction is completed After obtaining the Codonopsis pilosula ...

Embodiment 2

[0058] Embodiment 2: the preparation of Codonopsis pilosula segment dry product

[0059] The Codonopsis pilosula extract is vacuum-dried at 75° C. and ground into a dry powder, and auxiliary materials and water are added to the dry powder to prepare a wet material. Add 30g of auxiliary materials per 100g of dry powder in the wet material. Specifically, the auxiliary materials include 20 g of maltodextrin, 5 g of microcrystalline cellulose and 5 g of magnesium stearate. Dry powder and auxiliary materials are added with water to form a semi-dry mixture, and wet materials are added with water until they can be kneaded and formed, which is convenient for pressing into segments.

[0060] Then the wet material is extruded into strips, then cut to form 5 cm wet material of Codonopsis section, and then the wet material of Codonopsis section is vacuum-dried at a drying temperature of 55° C. until the moisture content is 4%, to obtain a dry product of Codonopsis section.

technical field

[0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method of Radix Codonopsis. Background technique

[0002] The source of Codonopsis Codonopsis is the dried roots of Codonopsis Codonopsis, Suhua Codonopsis, or Sichuan Codonopsis. Codonopsis is sweet in taste and flat in nature. There are invigorating vital energy, quenching thirst, invigorating the spleen and lungs, nourishing blood and promoting body fluid. Codonopsis pilosula has good medicinal value and is a common Chinese medicinal material used for both medicine and food.

[0003] Document 1: "Research Progress on Codonopsis Codonopsis Chemical Constituents and Pharmacological Actions", author Sun Zhenghua, etc. Document 1 discloses the main chemical components of Codonopsis pilosula, combined with other documents and prior art, it can be known that the active components of Codonopsis pilosula mainly include sugars, glycosides, steroid...

Examples

preparation example Construction

[0036] One embodiment of the present invention discloses a preparation method of Codonopsis Radix, comprising the following steps:

[0037] (1) Clean the fresh Codonopsis pilosula to remove impurities, then clean it, then cut the fresh Codonopsis pilosula into segments, wash it again and put it in an oven to dry until the water content is lower than 10%, then crush the dried Codonopsis pilosula again Dry until the moisture content is lower than 5%; obtain Codonopsis powder;

[0038] (2) Carry out supercritical extraction of Codonopsis Codonopsis powder with carbon dioxide, the extraction pressure of supercritical extraction is 25Mpa~35Mpa, the extraction temperature is 60°C~70°C, the flow rate of carbon dioxide is 1.5L / min~3L / min, and the extraction time is 2h~ 3h; entrainer flow rate is 0.5ml / min~1.5ml / min, entrainer is ethanol 60%~70% by weight, n-octyltrimethoxysilane 10%~20%, the balance is acetone; extraction is completed After obtaining Codonopsis pilosula extract;

[...

Embodiment 1

[0055] Embodiment 1: Preparation of Codonopsis Codonopsis Extract

[0056] (1), fresh Codonopsis pilosula is washed and cut off, and after cleaning again, it is placed in an oven and dried until the water content is 8%, then the dried Codonopsis pilosula is crushed and dried again until the water content is lower than 5%; then sieved, and 100-mesh powder is taken, Get Codonopsis powder;

[0057] (2), Codonopsis Codonopsis powder is subjected to carbon dioxide supercritical extraction, and the extraction pressure of supercritical extraction is 28Mpa, and extraction temperature is 68 ℃, and carbon dioxide flow rate is 2.2L / min, and extraction time is 2h; Entrainer flow rate is 1ml / min, entrains The agent is 65% by weight of ethanol, 15% of n-octyltrimethoxysilane, and the balance is 20% of acetone; that is, 65g of ethanol, 15g of n-octyltrimethoxysilane and 20g of acetone are prepared as entraining agents, and the extraction is completed After obtaining the Codonopsis pilosula ...

Embodiment 2

[0058] Embodiment 2: the preparation of Codonopsis pilosula segment dry product

[0059] The Codonopsis pilosula extract is vacuum-dried at 75° C. and ground into a dry powder, and auxiliary materials and water are added to the dry powder to prepare a wet material. Add 30g of auxiliary materials per 100g of dry powder in the wet material. Specifically, the auxiliary materials include 20 g of maltodextrin, 5 g of microcrystalline cellulose and 5 g of magnesium stearate. Dry powder and auxiliary materials are added with water to form a semi-dry mixture, and wet materials are added with water until they can be kneaded and formed, which is convenient for pressing into segments.

[0060] Then the wet material is extruded into strips, then cut to form 5 cm wet material of Codonopsis section, and then the wet material of Codonopsis section is vacuum-dried at a drying temperature of 55° C. until the moisture content is 4%, to obtain a dry product of Codonopsis section.

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