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The establishment method of the fingerprint of Yaoshen ointment and the control fingerprint of Yaoshen ointment

A technology for comparing fingerprints and fingerprints, which is applied in the field of pharmaceutical analysis, and can solve problems such as multiple components and complexity

Active Publication Date: 2022-03-08
SINOPHARM GRP DEZHONG (FOSHAN) PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its many and complex components, there is currently a lack of methods to fully reflect its quality and authenticity, and there is currently no research report on the fingerprint of Yaoshen paste. It has great significance and can provide a comprehensive quality control method for Yaoshen ointment

Method used

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  • The establishment method of the fingerprint of Yaoshen ointment and the control fingerprint of Yaoshen ointment
  • The establishment method of the fingerprint of Yaoshen ointment and the control fingerprint of Yaoshen ointment
  • The establishment method of the fingerprint of Yaoshen ointment and the control fingerprint of Yaoshen ointment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: Methodological verification

[0057] Select six batches of Yaoshen ointment of 18046, and prepare the test solution according to the proposed method. Take the first copy for precision and stability inspection; a total of six copies for repeatability inspection.

[0058] Preparation of the test solution: Take three pieces of waist and kidney paste, cut them into strips, tear off the backing, combine them into a group with one piece as a unit, stuff them into a 250ml flask, add 100ml of water, and connect with 2ml of ethyl acetate to extract the volatile oil. reflux on the electric heating mantle for 3 hours; let cool after reflux, put the ethyl acetate layer of the volatile oil extractor into a separatory funnel, rinse the volatile oil extractor with 2ml, 2ml, and 1ml of ethyl acetate respectively, wash the solution and Put it into a separatory funnel, discard the water layer, pass the ethyl acetate layer through the filter paper loaded with 1g of anhydrou...

Embodiment 2

[0087] Embodiment 2: the establishment of the fingerprint of Yaoshen ointment

[0088] 1. Exclude excipient peaks

[0089] 1. Peak of auxiliary materials in liquid chromatography

[0090] Waist and kidney ointment is made by spreading the mixed ointment on elastic cloth. The elastic cloth is soaked in methanol and ethanol, so that the dye on the elastic cloth is eluted and enters the test solution. For this reason, try to use 50% ethanol and 50% methanol to reflow the elastic cloth of Yaoshen plaster to reduce the amount of eluted dye, so as to reduce the interference of similarity evaluation.

[0091] Chromatographic conditions: Instrument: Agilent 1100 high performance liquid chromatography. The elution conditions are shown in Table 3 below. Other chromatographic conditions are the same as the experimental conditions proposed in Example 1.

[0092] table 3

[0093] time min Acetonitrile (%) 0.02% trifluoroacetic acid solution (%) 0 30 70 20 60 ...

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Abstract

The invention discloses a method for establishing the fingerprint of waist and kidney ointment, a comparison fingerprint of the waist and kidney ointment, and a method for establishing the fingerprint of the waist and kidney ointment. As the test sample for gas phase identification; the remaining paste is added with water, ultrasonically extracted with methanol, and the infusion is used as the test sample for liquid phase identification; (2) gas phase analysis is carried out for the test sample for gas phase identification to obtain the gas phase (3) liquid phase identification is carried out liquid phase analysis to the test sample, obtains the liquid phase fingerprint of Yaoshen ointment. Through the research on the fingerprint of Yaoshen paste, a better fingerprint of Yaoshen paste is obtained, which provides a new technical method for controlling the quality of the preparation.

Description

technical field [0001] The invention relates to the field of drug analysis, and mainly relates to a method for establishing a fingerprint of Yaoshen paste and a comparative fingerprint of Yaoshen paste. Background technique [0002] The prescription of waist and kidney ointment contains 20 kinds of medicinal materials such as cistanche, star anise, rehmannia glutinosa, psoralen, epimedium, cnidium, Achyranthes bidentata, Dipsacus, licorice, Eucommia, etc., plus camphor, borneol, peppermint oil, etc., and auxiliary materials It is white vaseline, rubber, terpene resin, etc. This product has the effects of warming the kidney and supporting yang, strengthening muscles and bones, dispelling wind and relieving pain. For kidney deficiency waist and knee pain, muscle pain, nocturia. Due to its many and complex components, there is currently a lack of methods to fully reflect its quality and authenticity, and there are currently no research reports on the fingerprints of Yaoshen p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/86
CPCG01N30/02G01N30/06G01N30/34G01N30/8686
Inventor 郭韵妍杜蔼媚招嘉文赵志峰邹婷
Owner SINOPHARM GRP DEZHONG (FOSHAN) PHARM CO LTD
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