Unlock instant, AI-driven research and patent intelligence for your innovation.

Standard substance of serum copper and preparation method and application thereof

A standard substance, serum copper technology, applied in the direction of measuring devices, instruments, material analysis through electromagnetic means, etc., can solve the problems of out of stock and high cost, and achieve the effect of good application prospects

Pending Publication Date: 2020-02-28
BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIV
View PDF10 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the National Institute of Standards and Technology (NIST) of the United States has multi-element standard materials in serum but none of them contain copper elements. The primary standard material GBW09152 frozen human serum contains 9 Elements, high cost, and currently out of stock

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Standard substance of serum copper and preparation method and application thereof
  • Standard substance of serum copper and preparation method and application thereof
  • Standard substance of serum copper and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] 1. Preparation of serum standard materials

[0055] According to relevant national standards, refer to ISO guidelines and relevant technical data of WHO, collect serum and prepare human serum copper standard materials. Through process control and inspection, the expected purpose is achieved.

[0056] 1. Preparation of serum standard materials:

[0057] Prepare two concentration levels of frozen human serum copper standard material 1000 each.

[0058] (1) Raw material screening

[0059] Visual inspection: remove samples of hemolysis, lipemia, and jaundice, and choose light yellow clear liquid serum as raw material.

[0060] Serum immunological test and screening: use immunological methods to detect pathogenic microorganisms in the serum. The test items include HBsAg, HCV antibodies, HIV-1 / HIV-2 antibodies, and Tp antibodies. Serum samples with positive results are removed, and HBsAg, HCV antibodies, The HIV-1 / HIV-2 antibody and Tp antibody test results are all negative samples.

...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention discloses a standard substance of serum copper and a preparation method and application thereof. A concentration definite value of the standard substance of the serum copper is 0.50-1.40mg / L; and a coverage factor k is equal to 2, and the uncertainty of the concentration definite value is 0.10-0.12 mg / L separately. According to the preparation method of the standard substance of theserum copper, the definite value is determined by flame atomic absorption spectrophotometry and inductively coupled plasma mass spectrometry, and the value is definite by two methods. The standard substance of serum copper fills a blank of the lack of single elemental standard substances of current serum copper, provides the economical and practical single element standard substance for serum copper detection, and provides quality control products for the quality control of clinical detection.

Description

Technical field [0001] The invention relates to a standard substance of serum copper and a preparation method and application thereof, and belongs to the technical field of standard quantity value transmission in stoichiometry. Background technique [0002] Copper is a metal trace element necessary for the normal physiological activities of the human body, and an important part of the protein and enzymes in the body. Copper is involved in a variety of metabolisms in the body, and plays an important role in the development and function of the blood, central system and immune system, hair, skin and bone tissues, brain tissue and internal organs such as liver and heart. Therefore, copper metabolism disorders will cause abnormalities in the body's normal physiological functions. There are significant differences in the diagnosis and treatment of various diseases between serum copper and the control group. The correlation between trace elements in the human body and diseases has alwa...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/31G01N27/62G01N27/626
CPCG01N21/3103G01N27/62
Inventor 李惠玲于燕张瑞张顺利叶俏王清涛
Owner BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIV