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Lacrimal duct suppository and preparation method thereof

A technology of lacrimal plug and gellan gum, which is applied in the field of medicine, can solve the problems of low structural matching between the lacrimal plug and the lacrimal canaliculus, low mechanical strength, and high mechanical strength, and achieve good curative effect, improve strength, and shear resistance strong effect

Active Publication Date: 2022-03-15
广州聚明生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the lacrimal plug made of conventional materials has a low matching degree with the lacrimal canaliculus. Its mechanical strength is small and it is easy to fall off, and its mechanical strength is high and it is easy to feel foreign body sensation.

Method used

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  • Lacrimal duct suppository and preparation method thereof
  • Lacrimal duct suppository and preparation method thereof
  • Lacrimal duct suppository and preparation method thereof

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preparation example Construction

[0031] In some of these embodiments, the preparation method of the polylactic acid-glycolic acid copolymer microspheres (PLGA microspheres) comprises: dissolving PLGA (polylactic acid-glycolic acid copolymer) in dichloromethane to prepare an initial emulsion; The obtained primary emulsion is mixed with the aqueous solution of Tween20 to prepare an emulsion; the obtained emulsion is stirred, filtered and freeze-dried to obtain PLGA microspheres.

[0032] In the present invention, the morphology of PLGA has an important influence on the function of PLGA in the lacrimal plug. When PLGA is added to the lacrimal plug in the form of microspheres, it has a better effect of improving mechanical properties. In addition, the preparation method of PLGA microspheres also has a certain influence on its effect in lacrimal plugs. The present invention selects PLGA to be dissolved in dichloromethane from numerous preparation methods of PLGA microspheres to prepare primary emulsion; The obtain...

Embodiment 1

[0058] The present embodiment provides a kind of lacrimal duct plug, and its preparation method is as follows:

[0059] (1) Prepare 30 mL of an aqueous solution of deacylated gellan gum (1% mass concentration).

[0060] (2) Add 0.9 g of ethyl[3-(dimethylamino)propyl]carbodiimide hydrochloride (EDAC), stir and react for 1 hour, and set the temperature at 20°C.

[0061] (3) Add 0.9 g of L-cysteine ​​hydrochloride, adjust the pH to 5.0 with NaOH, and react for 5 hours.

[0062] (4) The obtained reaction product is intercepted through a dialysis bag (molecular weight cut-off 12kDA-14kDA). The dialysis time was 48 hours, and the concentrated solution was taken as mercaptolated gellan gum.

[0063] (5) Add polylactic-co-glycolic acid (PLGA) microspheres accounting for 0.5 wt% of the mercapto-gellan gum to the prepared mercapto-gellan gum, and stir evenly at 40°C.

[0064] (6) Load the PLGA / mercapto-gellan gum complex into the syringe and store it at low temperature.

Embodiment 2

[0066] The present embodiment provides a kind of lacrimal duct plug, and its preparation method is as follows:

[0067] (1) Prepare 30 mL of an aqueous solution of deacylated gellan gum (2% mass concentration).

[0068] (2) Add 0.5 g of EDAC, stir and react for 1 hour, and set the temperature at 20°C.

[0069] (3) Add 0.5 g of L-cysteine ​​hydrochloride, adjust the pH to 5.0 with NaOH, and react for 5 hours.

[0070] (4) The obtained reaction product is intercepted through a dialysis bag (molecular weight cut-off 12kDA-14kDA). The dialysis time was 48 hours, and the concentrated solution was taken as mercaptolated gellan gum.

[0071] (5) Add PLGA microspheres accounting for 0.5 wt% of mercapto-gellan gum to the prepared mercapto-gellan gum, and stir evenly at 40°C.

[0072] (6) Load the PLGA / mercapto-gellan gum complex into the syringe and store it at low temperature.

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Abstract

The invention relates to a lacrimal duct plug and a preparation method thereof. The lacrimal plug is prepared from raw materials including mercaptolated gellan gum and polymer microsphere materials; the mercaptolated gellan gum is crosslinked from raw materials including deacylated gellan gum, a crosslinking agent and a mercaptool compound Formed; the mass ratio of the deacylated gellan gum, cross-linking agent and mercaptool compound is 0.1-1:0.1-3:0.1-3; the mass ratio of the mercaptolated gellan gum and the polymer microsphere material For 80‑120: 0.1‑2. The lacrimal duct plug of the invention has suitable mechanical properties, good adaptability to the structure of the lacrimal canaliculus, and good curative effect on dry eye.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a lacrimal duct plug and a preparation method thereof. Background technique [0002] Dry eye has become a common ocular surface disease that affects people's quality of life. In recent years, the incidence of dry eye in my country has gradually increased. According to literature reports, the incidence of dry eye worldwide is about 5% to 35%, among which women are higher than men, the elderly are higher than young people, and Asians are higher than other races. According to the existing epidemiological studies in China, the incidence of dry eye in my country is similar to that in other Asian countries, about 21% to 30%. [0003] Dry eye is often accompanied by an inflammatory response, and artificial tears can only rehydrate. Lacrimal embolism is a kind of physical therapy, mainly by partially sealing the tear drainage channel, reducing the patient's own tear loss, increasing the tear r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/14
CPCA61L31/042A61L31/06A61L31/14A61L2400/06C08L5/00C08L67/04
Inventor 凌友杨景郑钲彦
Owner 广州聚明生物科技有限公司