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Method for accelerating polyvinyl alcohol soluble microneedle forming and instant administration and prepared microneedle

A polyvinyl alcohol and soluble technology, applied in the field of medicine, can solve problems such as restricting the industrialization development of polyvinyl alcohol soluble microneedles, and achieve the effects of easy mass production, simple method and accelerated molding.

Pending Publication Date: 2020-04-03
BEIJING CAS MICRONEEDLE TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above three points seriously restrict the industrialization of polyvinyl alcohol soluble microneedles

Method used

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  • Method for accelerating polyvinyl alcohol soluble microneedle forming and instant administration and prepared microneedle
  • Method for accelerating polyvinyl alcohol soluble microneedle forming and instant administration and prepared microneedle
  • Method for accelerating polyvinyl alcohol soluble microneedle forming and instant administration and prepared microneedle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Preparation of polyvinyl alcohol-soluble microneedles containing magnesium chloride

[0052] 1. Use a pipette gun to pipette 6.92mL of ultrapure water into a 50mL centrifuge tube, use an electronic balance to accurately weigh 0.08g of magnesium chloride hexahydrate and add it to the centrifuge tube to dissolve, then weigh 3g of polyvinyl alcohol into the centrifuge tube, and stir Afterwards, heating and dissolving under the condition of 80° C., and removing air bubbles in the solution by centrifugation to obtain a microneedle preparation solution.

[0053] 2. Use a continuous sampling gun to draw 20 microliters of the microneedle solution prepared in step 1 and add it to each unit of the PDMS mold to make it evenly distributed. After adding the sample, vacuumize the solution to fill the microneedles under negative pressure conditions For pinholes, turn on the blowing equipment of the ultra-clean bench to dry the microneedles on the PDMS mold.

[0054] 3. Afte...

Embodiment 4-6

[0065] Example 4-6 Preparation of polyvinyl alcohol-soluble microneedles containing sodium alginate

[0066] According to the preparation method of Example 1, the polyvinyl alcohol soluble microneedles containing sodium alginate in Examples 4-6 were respectively prepared with reference to the corresponding prescriptions in Table 2, and the flatness, ductility, and drying time of the microneedles were evaluated. The results are shown in the table 2.

[0067] Table 2 Example 4-6 Polyvinyl Alcohol Soluble Microneedle Prescription and Acupuncture Effect

[0068]

Embodiment 7-15

[0069] Example 7-15 Preparation of polyvinyl alcohol integrated microneedles containing magnesium chloride, zinc chloride, and calcium chloride

[0070] According to the preparation method of Example 1, with reference to the corresponding prescriptions in Table 3, the polyvinyl alcohol integrated microneedles of Examples 7-15 containing magnesium chloride, zinc chloride, and calcium chloride were respectively prepared, and the flatness, ductility, and drying time of the microneedles were evaluated. For evaluation, the results are shown in Table 3.

[0071] Table 3 Example 7-15 Polyvinyl Alcohol Soluble Microneedle Prescription and Acupuncture Effect

[0072]

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Abstract

The invention discloses a method for accelerating polyvinyl alcohol soluble microneedle forming and instant administration and a prepared microneedle. The invention firstly discloses the method for accelerating polyvinyl alcohol soluble microneedle forming and instant administration. The method comprises the step of combining at least one water-soluble divalent inorganic salt or hydrate thereof orsodium alginate with polyvinyl alcohol for use. The invention further provides the microneedle prepared by the method. When the polyvinyl alcohol soluble microneedle is prepared, at least one water-soluble divalent inorganic salt or hydrate thereof or sodium alginate is added into polyvinyl alcohol. The crystallinity of polyvinyl alcohol is reduced, and the structural regularity is destroyed. Theactivity of a polyvinyl alcohol chain segment is enhanced, so that the formation of the polyvinyl alcohol soluble microneedle is accelerated. Instant administration is realized, and the moisture-proof stability of the needle body is improved. Good microneedle substrate flexibility and needle tip mechanical strength are kept. In addition, the method is simple, rapid and convenient for large-scaleproduction, and widens the application of polyvinyl alcohol in the field of soluble microneedles.

Description

technical field [0001] The invention relates to the technical field of medicine. More specifically, it relates to a method for accelerating polyvinyl alcohol-soluble microneedle forming and instant drug delivery and the prepared microneedle. Background technique [0002] Polyvinyl alcohol (PVA) is a biodegradable synthetic polymer material with good water solubility, biocompatibility, film-forming properties, thermal stability and mechanical properties, and is widely used in the preparation of soluble microneedles. [0003] There are a large number of hydrophilic hydroxyl groups in the molecular chain of polyvinyl alcohol, which are easy to cross-link to form intra-molecular chain and inter-hydrogen bonds, which makes polyvinyl alcohol have high crystallinity and obvious structural regularity. 1) makes polyvinyl alcohol The mobility of water molecules in the solution is weakened, and the water vapor permeability is not good (Hongguang Dai, Juan Wang, Lirong Wang. Preparatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0061
Inventor 高云华邢梦真杨国忠张锁慧
Owner BEIJING CAS MICRONEEDLE TECH LTD
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