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A single-atom nano-enzyme patch for skin wounds and its preparation method

A skin wound and nano-enzyme technology, applied in the field of medicine, can solve the problems of lack of in vivo curative effect and toxic and side effects research reports, which have not yet been discovered, and achieve the effect of promoting wound healing without toxic and side effects

Active Publication Date: 2022-04-05
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through domestic and foreign literature and patent research, no relevant single-atom Pt / CeO 2 Research reports on catalyst treatment of skin damage, especially Pt / CeO 2 The research on the components of biomedical devices is still blank, and there is even a lack of research reports on its curative effect and side effects in vivo

Method used

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  • A single-atom nano-enzyme patch for skin wounds and its preparation method
  • A single-atom nano-enzyme patch for skin wounds and its preparation method
  • A single-atom nano-enzyme patch for skin wounds and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation method of the single-atom nano-enzyme patch for skin wounds comprises the steps:

[0025] (1) 110mg Ce(NO 3 ) 3 ·6H 2 O was dissolved in 10 mL of deionized water to obtain solution 1; 130 mg of 6-aminocaproic acid and 5 μL of concentrated hydrochloric acid were dissolved in 1 mL of deionized water under stirring to obtain solution 2; at room temperature, 2 mL of concentrated ammonia water was added to solution 1, Stir evenly, heat to 93°C, add solution 2, react for 3.5 hours, cool to room temperature, wash with water, and centrifuge to obtain CeO 2 Cluster;

[0026] (2) Prepare 90mg / mL of CeO 2 Aqueous suspension of clusters, 15 mg of polyvinylpyrrolidone with MW ≈ 58000 and 25 mg of K 2 PtCl 4 Add to 8mL water, obtain solution three; With 1mL said CeO 2 Add the cluster aqueous suspension to solution 3, react at 93°C for 18 minutes, then add 0.8mL of newly prepared 80mM NaBH dropwise 4 Aqueous solution; react at 93°C for 25 minutes; cool to room ...

Embodiment 2

[0030] The preparation method of the single-atom nano-enzyme patch for skin wounds comprises the steps:

[0031] (1) 100mg Ce(NO 3 ) 3 ·6H 2 O was dissolved in 10 mL of deionized water to obtain solution 1; under stirring, 120 mg of 6-aminocaproic acid and 5 μL of concentrated hydrochloric acid were dissolved in 1 mL of deionized water to obtain solution 2; at room temperature, 2 ml of concentrated ammonia water was added to solution 1, Stir evenly, heat to 90°C, add solution 2, react for 4 hours, cool to room temperature, wash with water, and centrifuge to obtain CeO 2 Cluster;

[0032] (2) Prepare 80mg / mL of CeO 2 Aqueous suspension of clusters, 10 mg of polyvinylpyrrolidone with MW ≈ 58000 and 10 mg of K 2 PtCl 4 Add to 5mL water, obtain solution three; With 1mL said CeO 2 The aqueous cluster suspension was added to Solution 3, reacted at 90°C for 20 minutes, and then 0.8mL of newly prepared 50mM NaBH was added dropwise. 4 Aqueous solution; react at 90°C for 30 minu...

Embodiment 3

[0036] The preparation method of the single-atom nano-enzyme patch for skin wounds comprises the steps:

[0037] (1) 120mg Ce(NO 3 ) 3 ·6H 2 O was dissolved in 10 mL of deionized water to obtain solution 1; under stirring, 140 mg of 6-aminocaproic acid and 5 μL of concentrated hydrochloric acid were dissolved in 1 mL of deionized water to obtain solution 2; at room temperature, 2 ml of concentrated ammonia water was added to solution 1, Stir evenly, heat to 95°C, add solution 2, react for 3 hours, cool to room temperature, wash with water, and centrifuge to obtain CeO 2 Cluster;

[0038] (2) Prepare 100mg / mL of CeO 2 Aqueous suspension of clusters, 20 mg of polyvinylpyrrolidone with MW ≈ 58000 and 40 mg of K 2 PtCl 4 Add to 10mL water, obtain solution three; With 1mL said CeO 2 Add the cluster aqueous suspension to Solution 3, react at 95°C for 15 minutes, and then drop in 0.8mL of newly prepared 100mM NaBH 4 Aqueous solution; react at 95°C for 20 minutes; cool to room...

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Abstract

The invention discloses a single-atom nano-enzyme patch used for skin wounds and a preparation method. Preparation: preparing Ce(NO 3 ) 3 ·6H 2 O water is solution one; preparation of 6-aminocaproic acid and concentrated hydrochloric acid water is solution two; concentrated ammonia water is added to solution one, stirred, added solution two, and reacted to obtain CeO 2 cluster and prepare an aqueous suspension, the polyvinylpyrrolidone and K 2 PtCl 4 added to water to obtain solution three; the CeO 2 The cluster water suspension was added to solution three, reacted, and then NaBH was added dropwise 4 Aqueous solution; reaction; obtain single-atom nanozyme, drop on activated hydrophilic carbon cloth; dry to obtain activated hydrophilic carbon cloth containing single-atom nanozyme; arrange activated hydrophilic carbon cloth containing single-atom nanozyme in sequence on the upper surface of the medical tape Carbon cloth and release paper to obtain a single-atom nanozyme patch for skin wounds. The patch of the invention can significantly promote wound healing, scar repair and hair regeneration in the later period, and has no toxic and side effects.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to an external patch. Background technique [0002] Skin trauma is a worldwide health problem that poses increasing challenges to clinical treatment [1,2] . Efficiently restoring tissue integrity and function while minimizing aesthetic impact following injury remains a central concern of clinical care. The regenerative healing of injured tissue remains elusive, possibly due to the fact that most current wound healing treatments focus on the structural restoration process, while the regulation of the microenvironment at the injured site utilizing the host's intrinsic regenerative capacity has been seldom explored. Skin injury triggers a chain of events in which free radicals (RONS) are proliferated in the wound site microenvironment [3,4] , is part of its defense mechanism against pathogen invasion. Although this process is beneficial, uncontrolled excess production of RONS may impede wou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/244A61K9/70A61P17/02A61P17/14
CPCA61K33/244A61K9/7023A61K47/32A61P17/02A61P17/14
Inventor 张晓东闫瑞娟孙思穆晓宇刘爽杰
Owner TIANJIN UNIV
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