Reagent for predicting treatment reactivity of children with Kawasaki disease and application of reagent
A technology of detection reagents and kits, which is applied in the fields of genetic engineering and molecular genetics, can solve the problems of comparison and verification of multiple gene analysis, and achieve the effect of low cost and easy operation
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0050] Example 1: Detection of susceptibility genes of Kawasaki disease IVIG unresponsive type
[0051] We selected 231 KD children (77 IVIG non-responsive KD children and 154 IVIG sensitive KD children) who were hospitalized in the Department of Cardiology, Children's Hospital Affiliated to Capital Institute of Pediatrics from December 2015 to August 2019. The selected KD diagnostic criteria include: fever for more than 5 days, accompanied by 4 of the following 5 clinical manifestations, and after excluding other diseases, it is diagnosed as Kawasaki disease: (1) Changes in limbs: rigid edema of hands and feet in the acute stage, fingers (toes) in the recovery stage ) terminal membranous desquamation; (2) erythema multiforme; (3) non-suppurative hyperemia of conjunctiva; (4) oral mucosal hyperemia, red bayberry tongue; (5) cervical lymph node enlargement; Less than 4 items, but coronary artery damage in echocardiography can be diagnosed as incomplete Kawasaki disease. The di...
Embodiment 2
[0106] Example 2: Establishment of predictive scoring model for IVIG resistance in children with KD - nomogram creation and verification The old predictive model established by our hospital based on laboratory biochemical indicators is shown in Table 7.
[0107] Table 7 Prediction models based on biochemical indicators
[0108]
[0109] Construction of a new predictive model for gene joint laboratory indicators:
[0110] In this study, the 4 SNPs related to the IVIG-responsive type of KD children and the prediction model indicators based on the previous laboratory biochemical indicators in our hospital were used as variables, and 6 patients with incomplete laboratory indicators were excluded from the 231 KD patients. Finally, 225 KD children (75 IVIG non-responsive KD children and 150 IVIG sensitive KD children) were included in the next step to build a new prediction model. The nomogram for predicting IVIG response made by R software assigns scores to each variable as fol...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com