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Composite artificial blood vessel and preparation method thereof

An artificial blood vessel and composite technology, applied in the field of artificial blood vessels, can solve the problem that smooth muscle cells and fibroblasts are difficult to infiltrate in large quantities, and achieve the effects of good adhesion, good repeatability, and high economic benefits

Pending Publication Date: 2020-04-14
SHANGHAI CHANGDY MEDICAL CO LTD
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem that smooth muscle cells and fibroblasts are difficult to infiltrate in large quantities before the existing electrospun nanofiber artificial blood vessels are degraded and broken in large quantities, the present invention provides a composite artificial blood vessel that can degrade Nanofiber small-diameter artificial blood vessels can achieve three-dimensional infiltration of autologous cells and regeneration of new tissue before the fibers start to degrade in large quantities, so that the blood vessels still have good strength and elasticity when the fibers degrade in large quantities

Method used

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  • Composite artificial blood vessel and preparation method thereof
  • Composite artificial blood vessel and preparation method thereof

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preparation example Construction

[0047] The preparation method of the above-mentioned artificial blood vessel is: comprising:

[0048] a. Prepare the blended spinning solution of collagen / PLCL, the mass ratio of collagen / PLCL is 50:50 or 25:75, the concentration of spinning solution is 6%-12%, and the solvent is hexafluoroisopropanol;

[0049] b. use the spinning solution prepared in step a to prepare a nanofiber membrane with a thickness of 5-50 microns by electrospinning, and the spinning voltage is 8-20kV;

[0050] c. Use the nanofiber membrane prepared in step b to wind a certain number of nanofiber membranes on the stainless steel rod according to the thickness of the first nanofiber layer 1, and prepare the nanofiber layer 1 by hot pressing at 45-55°C;

[0051] d. Prepare PLCL spinning solution, the concentration of spinning solution is 6%-12%, and the solvent is hexafluoroisopropanol;

[0052] e. Use the spinning solution prepared in step d to prepare PLCL nanofiber membranes by electrospinning, then ...

Embodiment 1

[0057] Prepare the spinning solution of collagen / PLCL (caprolactone lactate copolymer) blend, the mass ratio of collagen / PLCL is 50:50, the concentration of spinning solution is 10% w / v, and the solvent is hexafluoroisopropyl alcohol. A nanofiber membrane with a thickness of 10 microns was prepared by electrospinning, and the spinning voltage was 12kV. The prepared nanofiber membrane was wound on a 3.0mm stainless steel rod for 7 layers, and hot-compressed at 50°C. The first nanofiber layer 1, the thickness of the first nanofiber layer 1 is 56 microns.

[0058] Prepare the PLCL spinning solution, the concentration of the spinning solution is 8%, and the solvent is hexafluoroisopropanol. The PLCL nanofiber membrane was prepared by electrospinning, then the PLCL nanofiber membrane was cut into pieces, placed in deionized water, and the fibers were dispersed evenly by a high-speed homogenizer to prepare a nanofiber solution with a concentration of 35%. The solution needs to be ...

Embodiment 2

[0063] A collagen / PLCL blended spinning solution was prepared, the mass ratio of collagen / PLCL was 25:75, the concentration of the spinning solution was 9% w / v, and the solvent was hexafluoroisopropanol. A nanofiber membrane with a thickness of 10 microns was prepared by electrospinning, and the spinning voltage was 12kV. The prepared nanofiber membrane was wound 8 layers on a 4.0mm stainless steel rod, and hot-compressed at 50°C. The thickness of the first nanofiber layer 1 measured by a laser caliper is 62 microns.

[0064] Prepare the PLCL spinning solution, the concentration of the spinning solution is 8%, and the solvent is hexafluoroisopropanol. The PLCL nanofiber membrane was prepared by electrospinning, then the PLCL nanofiber membrane was cut into pieces, placed in deionized water, and the fibers were dispersed evenly by a high-speed homogenizer to prepare a nanofiber solution with a concentration of 40%. The solution needs to be vacuum degassed before use.

[0065]...

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Abstract

The invention relates to a composite artificial blood vessel and a preparation method thereof. The artificial blood vessel has a double-layer tubular structure, and comprises a first nanofiber layer arranged on the inner layer and a second nanofiber layer arranged on the outer layer, wherein the first nano-fiber layer and the second nano-fiber layer are connected in an adhering manner, the first nanofiber layer is formed by rolling one, two or more layers of nanofiber membranes, the second nanofiber layer has an integrally formed structure, and microporous structures are arranged on the firstnanofiber layer and the second nanofiber layer. According to the invention, the degradable nanofiber small-caliber artificial blood vessel achieves three-dimensional infiltration of autologous cells and regeneration of new tissues before a large number of fibers begin to be degraded, so that the blood vessel still has good strength and good elasticity when the fibers are degraded in a large number.

Description

technical field [0001] The invention relates to an artificial blood vessel, in particular to a composite artificial blood vessel and a preparation method thereof. Background technique [0002] The vascular system includes the heart, blood vessels, and blood. The heart transports fresh blood to various parts of the body through large and small blood vessels to exchange nutrients and waste in the body to ensure the normal function of various organs. However, atherosclerosis, hemangioma, and external trauma cause a variety of arterial and venous vascular defects, and it is necessary to use vascular substitutes of different diameters through surgery to replace the corresponding diseased blood vessel, bypass and other repair treatments. Blood vessel substitutes generally include autologous blood vessels, xenograft blood vessels, allogeneic blood vessels, and artificial blood vessels. Since autologous blood vessels are often limited by factors such as the age of the patient, exis...

Claims

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Application Information

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IPC IPC(8): A61F2/06D01D5/00D04H1/728B32B9/00B32B9/04B32B3/24B32B37/06B32B37/10A61L27/40A61L27/18A61L27/24A61L27/58A61L27/56A61L27/50
CPCA61F2/06A61F2/0077D04H1/728D01D5/0015D01D5/003B32B5/024B32B5/26B32B3/266B32B37/06B32B37/10A61L27/18A61L27/24A61L27/58A61L27/56A61L27/50A61L27/507A61F2002/0081A61F2210/0004A61F2210/0076A61F2240/002A61F2250/0023B32B2262/02B32B2307/51C08L67/04
Inventor 陈剑锋杜广武
Owner SHANGHAI CHANGDY MEDICAL CO LTD
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