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Application of picroside II in preparation of drugs treating hyperlipemia

A technology of hyperlipidemia and berberine, which is applied in the field of medicine, can solve unknown problems and achieve a good protective effect

Inactive Publication Date: 2020-04-14
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the mechanism of the anti-oxidative stress of berberine Ⅱ is still unknown

Method used

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  • Application of picroside II in preparation of drugs treating hyperlipemia
  • Application of picroside II in preparation of drugs treating hyperlipemia
  • Application of picroside II in preparation of drugs treating hyperlipemia

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Embodiment Construction

[0013] Further illustrate the present invention by the following examples, do not limit the present invention in any way, under the premise of not departing from the technical solution of the present invention, any modification or change that those of ordinary skill in the art that the present invention is done to realize easily will all be fall within the scope of the claims of the present invention.

[0014] 1. Cell oil red staining experiment

[0015] HepG2 cells were cultured in DMEM medium containing 10% FBS, 100U / mL penicillin and 100U / mL streptomycin, and incubated in a constant temperature incubator at 5% CO2 at 37°C. Will be about 5 x 10 3 HepG2 cells were planted in a 24-well cell culture plate. The blank group was added with medium, the model group was added with stimulant (oleic acid & palmitic acid: 1mM), and the drug treatment group was added with 100μM pugracein Ⅱ and stimulator (oleic acid & palmitic acid: 1mM). palmitic acid: 1 mM), and the drug control grou...

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Abstract

The invention provides application of picroside II in preparation of drugs treating hyperlipemia. Cell oil red staining, mouse liver pathological section and liver oil red staining prove that picroside II can effectively inhibit the aggregation of lipid in HepG2 cells in hyperlipemia diseases, and improve lipid accumulation and inflammatory response in the liver. According to the invention, picroside II is employed to treat hyperlipemia, no obvious toxic effect exists in tests, and the picroside II has a good curative effect. Therefore, picroside II can be used for new drug development, and has important significance for drug target confirmation.

Description

technical field [0001] The invention relates to the application of berberine II in the preparation of medicines for treating non-alcoholic fatty liver disease, and belongs to the field of medicine. Background technique [0002] Non-alcoholic fatty liver disease is a kind of liver cell steatosis not caused by alcohol as the main cause, but caused by other clear liver damage factors or extreme fat deposition in the liver, and is associated with insulin resistance, type 2 diabetes, obesity associated with metabolic syndrome. Nonalcoholic fatty liver disease is mainly divided into simple fatty liver and its evolving nonalcoholic steatohepatitis and fatty cirrhosis. In recent years, there have been many studies on drugs for the treatment of non-alcoholic fatty liver disease. Currently, several drugs are being tested for the treatment of non-alcoholic fatty liver disease, including vitamin E, glitazones and liraglutide. However, due to their various side effects, they are not of...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P3/06
CPCA61K31/7048A61P3/06
Inventor 冯海华李铮赵立磊徐蕾李金霞邓旭明邓彦宏
Owner JILIN UNIV