Applications of bear gall dropping pills in preparation of antibacterial drugs

A technology of antibacterial drugs and dropping pills, applied in the field of biopharmaceuticals, to achieve the effect of inhibiting protein synthesis

Pending Publication Date: 2020-04-14
SHANGHAI KAIBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report about the application of Xiongdan Dropping Pills in the preparation of antibacte

Method used

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  • Applications of bear gall dropping pills in preparation of antibacterial drugs
  • Applications of bear gall dropping pills in preparation of antibacterial drugs
  • Applications of bear gall dropping pills in preparation of antibacterial drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment one: the preparation of Xiongdan dripping pills

[0020] Xiongdan dripping pills were prepared according to the preparation method in the invention patent application 200410040574.8. The raw material bear bile powder used in the present invention is the dried bile of black bears or brown bears.

[0021] The present embodiment takes the preparation of Xiongdan dripping pills as an example, and the steps are as follows:

[0022] 1. Preparation of bear bile powder

[0023] Take the bear bile, dry it, crush it, and store it in a desiccator for future use.

[0024] 2. Preparation of Xiongdan Dropping Pills

[0025] (1) Add bear bile powder into melted polyethylene glycol 6000 or polyethylene glycol 4000 matrix, stir well, drop into drop pills, drain the coolant to obtain final product;

[0026] (2) The mechanisms used include but are not limited to polyethylene glycol 4000, polyethylene glycol 6000, sodium stearate, gelatin;

[0027] (3) The coolant used incl...

Embodiment 2

[0029] Example 2: Effect of Xiongdan Dripping Pills on Staphylococcus aureus-induced mouse infection model

[0030] 1. Materials

[0031] 1.1 Experimental animals

[0032] 1.1.1 Basic situation

[0033] (1) Animal strain: ICR mouse.

[0034] (2) Age: 4-6 weeks old.

[0035] (3) Gender: half male and half male

[0036] (4) Weight range: 18-24g.

[0037] (5) Source: Hunan Slack Jingda Experimental Animal Co., Ltd.

[0038] (6) Grade: SPF grade.

[0039] (7) Experimental animal production license number: SCXK (Xiang) 2016-0002 (valid until September 30, 2021), issued by Hunan Provincial Department of Science and Technology. Experimental animal quality certificate number: 43004700047690, 43004700048152, 43004700049697, 43004700051843.

[0040] 1.1.2 Animal grouping method:

[0041] After the quarantine, the mice that passed the quarantine observation were selected and randomly divided into 6 groups according to their body weight and gender balance: negative control group,...

Embodiment 3

[0075] Example 3: Effect of Xiongdan Dropping Pills on Mouse Infection Model Caused by Streptococcus pneumoniae

[0076] 1. Materials

[0077] 1.1 Experimental animals

[0078] 1.1.1 Basic situation

[0079] (1) Animal strain: ICR mouse.

[0080] (2) Age: 4-6 weeks old.

[0081] (3) Gender: half male and half male

[0082] (4) Weight range: 18-24g.

[0083] (5) Source: Hunan Slack Jingda Experimental Animal Co., Ltd.

[0084] (6) Grade: SPF grade.

[0085] (7) Experimental animal production license number: SCXK (Xiang) 2016-0002 (valid until September 30, 2021), issued by Hunan Provincial Department of Science and Technology. Experimental animal quality certificate number: 43004700047690, 43004700048152, 43004700049697, 43004700051843.

[0086] 1.1.2 Animal grouping method:

[0087] After the quarantine, the mice that passed the quarantine observation were selected and randomly divided into 6 groups according to their body weight and gender balance: negative control g...

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Abstract

The invention discloses applications of bear gall dropping pills in preparation of antibacterial drugs. According to the invention, the antibacterial pharmacodynamic activity of bear gall dropping pills is studied, and the experimental study of bear gall dropping pills on mouse infection models caused by staphylococcus aureus and streptococcus pneumoniae is carried out; and through the animal experiments on the influence of bear gall dropping pills on mouse staphylococcus aureus and streptococcus pneumoniae infection models, it is accidentally found that the bear gall dropping pills can prolong the survival time of animals, improve the survival rate of the animals, reduce the lung index and reduce the pulmonary lesion rate, so that the application prospect of the bear gall dropping pills in preparation of antibacterial drugs is revealed.

Description

technical field [0001] The invention relates to the technical field of biopharmaceuticals, in particular to the application of Xiongdan dripping pills in the preparation of antibacterial drugs. Background technique [0002] Bear bile, obtained from the dried gallbladder bile of black bears or brown bears, has the effects of clearing away heat, calming the liver, and improving eyesight. Its main component is tauroursodeoxycholic acid (TUDCA). Bear bile is one of the four famous and precious animal medicines. It has a history of more than 2,000 years of use, and a large number of prescriptions contain bear bile. [0003] The dosage form of the existing bear bile powder is bear bile capsule, which is recorded in "The Ministry of Health of the People's Republic of China Drug Standards of Traditional Chinese Medicine Prescriptions Volume 13". Currently, it is generally processed into common capsules for use, and the bioavailability is low. Clinically, an efficient and convenient...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61K9/20A61K47/10A61P31/04
CPCA61K35/413A61K9/2031A61P31/04
Inventor 张小利穆竟伟王国明薛东升
Owner SHANGHAI KAIBAO PHARMA
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