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A method for simultaneously preparing rare ginseng saponins and oil unsaponifiables

A technology for rare saponins and saponins of ginseng, which is applied in pharmaceutical formulations, plant raw materials, medical preparations containing active ingredients, etc., can solve the problems of not seeing oil unsaponifiables and ginsenosides, cumbersome operations, waste of manpower and material resources, etc. , to achieve the effect of large development value, simplified operation and time saving

Active Publication Date: 2022-01-18
CHANGCHUN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above-mentioned technology has the following defects: (1) when the existing methods obtain the unsaponifiable matter in the oil, most of the oil is used as the starting research material; (2) when the existing method prepares the unsaturated saponifiable matter of the oil, it usually takes After six steps of oil extraction from raw materials, concentration, oil preparation, saponification, extraction, and washing, the steps are relatively independent, and the operation is cumbersome and wastes manpower and material resources.
(4) There is no report on the simultaneous preparation of oil unsaponifiables and ginsenosides

Method used

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  • A method for simultaneously preparing rare ginseng saponins and oil unsaponifiables
  • A method for simultaneously preparing rare ginseng saponins and oil unsaponifiables
  • A method for simultaneously preparing rare ginseng saponins and oil unsaponifiables

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Experimental program
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Effect test

Embodiment １

[0032] Process the dried ginseng into powder, take 5g, add 50mL petroleum ether, 1.0g sodium hydroxide, 25mL n-butanol, 50mL ethanol, 50mL water, extract with a stirring tank or a stirrer, the stirring shaft speed: 120 rpm, The temperature is: 140 degrees Celsius, the heating time is 0.5 hours, after the heating is completed, let it stand for 90 minutes, take the upper layer solution, and concentrate under reduced pressure or normal pressure to obtain the unsaponifiable matter of ginseng oil. Take the solution in the lower layer, concentrate it to 1 / 4 of the original volume, add 2.5g of macroporous resin, the type of macroporous resin is D101, first elute with water until the ethanol eluent is colorless, clear and transparent, with a pH value of 7, Then elute with ethanol solution with a volume ratio of 40%, until the ethanol eluate is colorless, clear and transparent, collect the ethanol eluate, recover ethanol, and dry to obtain rare ginseng saponins in the form of dry extrac...

Embodiment 2

[0049] Process dried ginseng into powder, take 5g, add 100 mL petroleum ether, 1.5 g sodium hydroxide, 50 mL n-butanol, 80 mL ethanol, 150 mL water, extract with a stirring tank or a stirrer, stirring shaft speed: 140 rpm, temperature: 120°C, heating time: 1.0 hour, after heating, let stand for 150 min, take the upper layer solution, concentrate under reduced pressure or normal pressure, and obtain ginseng oil unsaponifiable matter. Take the solution in the lower layer, concentrate to 1 / 5 of the original volume, add 5.0 g of macroporous resin, the type of macroporous resin is D130, first elute with water until the ethanol eluent is colorless, clear and transparent, and the pH value is 7, Then elute with ethanol solution with a volume ratio of 50%, until the ethanol eluate is colorless, clear and transparent, collect the ethanol eluate, recover ethanol, and dry to obtain rare ginseng saponins in the form of dry extract.

Embodiment 3

[0051] Process dried ginseng into powder, take 5g, add 150 mL of petroleum ether, 2.0 g of sodium hydroxide, 80 mL of n-butanol, 150 mL of ethanol, 250 mL of water, use a stirring tank or a stirrer for extraction, stirring shaft speed: 160 rpm, temperature: 105°C, heating time: 1.5 hours, after heating, let it stand for 120 minutes, take the upper layer solution, concentrate under reduced pressure or normal pressure, and obtain ginseng oil unsaponifiable matter. Take the lower layer solution, concentrate to 1 / 6 of the original volume, add 6.0 g macroporous resin, the type of macroporous resin is AB8, first elute with water until the ethanol eluent is colorless, clear and transparent, and the pH value is 7, Then elute with ethanol solution with a volume ratio of 50%, until the ethanol eluate is colorless, clear and transparent, collect the ethanol eluate, recover ethanol, and dry to obtain rare ginseng saponins in the form of dry extract.

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Abstract

The invention provides a method for simultaneously preparing rare ginseng saponins and oil unsaponifiables, belonging to the field of preparation methods of ginseng extracts. In this method, dry ginseng is processed into powder, and petroleum ether, sodium hydroxide, n-butanol, ethanol and water are added, and a stirring device is used for extraction; after the extraction, it is left standing, and the upper layer solution is taken, and concentrated under reduced pressure or normal pressure to obtain Unsaponifiable matter of ginseng oil; take the lower layer solution, concentrate, put it on a macroporous resin column, elute with water until the ethanol eluent is colorless, clear and transparent, then elute with ethanol solution until the ethanol eluent is free The color is clear and transparent, the ethanol eluate is collected, the ethanol is recovered, and dried to obtain rare ginseng saponins in the form of dry extract. This method can prepare ginseng rare saponins and oil unsaponifiables at the same time, which is convenient, efficient, easy to operate, and low in cost, improves the utilization of ginseng, and can meet the development and utilization of medicine, food, chemical industry, and has great application and development value big.

Description

technical field [0001] The invention belongs to the field of preparation methods of ginseng extracts, in particular to a method for simultaneously preparing rare ginseng saponins and oil unsaponifiables. Background technique [0002] Ginseng is Araliaceae plant ginseng ( Panax ginseng C. A. Mey) dry roots. Nature and flavor: sweet, slightly bitter, warm and flat. Return spleen, lung meridian, heart meridian. Invigorating qi, solidifying, promoting body fluid, calming the nerves, and improving intelligence. Indications: Deficiency of the body, cold limbs, slight pulse, spleen deficiency, lack of food, lung deficiency, wheezing and coughing, thirsty body fluid wound, internal heat and thirst, chronic illness and weakness, palpitations and insomnia, impotence and uterine cold; heart failure, cardiogenic shock. It is used for shortness of breath, palpitation, forgetfulness, excessive thirst and sweating, lack of appetite and weakness, all acute and chronic diseases and shock...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61K125/00
CPCA61K36/258A61K2236/35A61K2236/51A61K2236/55
Inventor 李赛男刘春明王恩发张语迟时东方
Owner CHANGCHUN NORMAL UNIVERSITY
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