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Schizophrenia biomarker combination and applications thereof, and metaphlan2 screening method

A biomarker and technology for schizophrenia, applied in the field of kits for diagnosing or predicting the risk of schizophrenia, can solve the problems that early warning of schizophrenia diagnosis cannot be achieved, and the onset and development trend of schizophrenia cannot be predicted. Achieve accurate disease risk assessment and improve efficiency

Pending Publication Date: 2020-04-17
SHENZHEN HUADA GENE INST +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The problem to be solved by the present invention is to provide a biomarker combination for schizophrenia based on intestinal flora and its application, which can overcome the inability of the existing schizophrenia diagnosis to achieve early warning, the inability to predict the onset and development trend of schizophrenia, etc. Disadvantages, can help disease pathological classification and for drug target research, precise drug use, pathogenesis research, etc.

Method used

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  • Schizophrenia biomarker combination and applications thereof, and metaphlan2 screening method
  • Schizophrenia biomarker combination and applications thereof, and metaphlan2 screening method
  • Schizophrenia biomarker combination and applications thereof, and metaphlan2 screening method

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Embodiment 1

[0077] 1.1 Sample Collection

[0078] Referring to the method described in the literature A metagenome-wide association study of gut microbiota in type2 diabetes (Qin J et al. Nature. 2012, 490, 55-60), the feces samples were collected and transported frozen and quickly transferred to -80°C for storage. DNA extraction to obtain an extracted DNA sample. The stool samples of the schizophrenia and non-schizophrenia subjects of the present invention were from China. A total of 171 cases, including 81 healthy samples and 90 schizophrenic samples.

[0079] 1.2 Metagenome sequencing and assembly

[0080] The extracted DNA samples were used to construct a sequencing library, and two-way (Paired-end) metagenomic sequencing (insert fragment 350bp, read length 100bp) was performed on the Illumina HiSeq2000 sequencing platform. Filter the data generated by sequencing (quality-controlled), remove adapter contamination sequences, low-quality sequences and host genome contamination sequen...

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Abstract

The invention discloses an intestinal flora-based schizophrenia biomarker combination and applications thereof. According to the invention, based on the influence on biomarkers before and after use ofcandidate drugs, whether the candidate drugs can be used for treating or preventing schizophrenia is determined; and the defects that the existing schizophrenia diagnosis method cannot achieve earlywarning, cannot predict schizophrenia attack and development trends and the like are overcome, so that the intestinal flora-based schizophrenia biomarker combination can be applied to prediction of schizophrenia attack and development trends and preparation and application of kits applied to pathological typing of diseases.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a biomarker of schizophrenia based on intestinal flora, a kit for diagnosing or predicting the risk of schizophrenia and its application. Background technique [0002] Schizophrenia (English: Schizophrenia) is a group of severe mental illnesses of unknown etiology, mostly in young adults with slow or subacute onset, clinically often manifested as a syndrome with various symptoms, involving perception, thinking, emotion and behavior Many other obstacles and incoordination of mental activities. Patients generally have clear consciousness and basically normal intelligence, but some patients will be accompanied by cognitive impairment during the course of the disease. The course of the disease is generally protracted, showing repeated attacks, aggravation or deterioration, and most patients eventually suffer from decline and mental disability, and only a small number of patients c...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12Q1/689C12Q1/6809
CPCC12Q1/6883C12Q1/689C12Q1/6809C12Q2600/106C12Q2600/136C12Q2600/158C12Q2535/122C12Q2537/165
Inventor 王奇马现仓鞠艳梅朱峰郭锐进王崴贾慧珏范雅娟马青艳郭丽阳高成阁
Owner SHENZHEN HUADA GENE INST
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