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Clonidine transdermal patch and preparation method thereof

A clonidine and transdermal patch technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and devices that make medicines into special physical or oral forms, etc., can solve the problem of coating uniformity and poor content uniformity. , affecting the therapeutic effect of clonidine transdermal patch, etc., to achieve the effect of convenient operation, simple structure and improved therapeutic effect

Inactive Publication Date: 2020-04-21
范小玲 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The therapeutic effect of clonidine transdermal patch is closely related to the coating uniformity and content uniformity of the drug. At present, the coating uniformity and content uniformity of the clonidine breathable patch prepared by the existing preparation method are relatively poor. Seriously affected the therapeutic effect of clonidine transdermal patch, so on the basis of solving the precision of production equipment, we should also optimize the key production process steps, find out the key process parameters that affect the coating uniformity, and finally ensure the uniformity of product content

Method used

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  • Clonidine transdermal patch and preparation method thereof

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Embodiment Construction

[0034] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further described below in conjunction with specific illustrations.

[0035] refer to figure 1 As shown in the figure, a clonidine transdermal patch is shown, including an anti-adhesive film 500 , an adhesive layer 400 , a release-controlling film 300 , a drug reservoir layer 200 and a backing film 100 .

[0036] The adhesive layer 400 is coated between the anti-adhesive film 500 and the controlled-release film 300, the drug reservoir layer 200 is coated between the controlled-release film 300 and the backing film 100, and the ingredients of the adhesive layer 500 and the drug reservoir layer 200 are cola It must account for 2.5% to 4% of the total amount of the drug, and the rest of the excipients account for 96% to 97.5% of the total amount of the drug.

[0037] In this embodiment, the remaining auxiliary mater...

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Abstract

The invention discloses a clonidine transdermal patch comprising an anti-sticking film, an adhesive layer, a controlled-release film, a drug storage layer and a backing film; the adhesive layer is coated between the anti-sticking film and the controlled-release film, the drug storage layer is coated between the controlled-release film and the backing film, colchicine in the adhesive layer and thedrug storage layer accounts for 2.5%-4% of the total amount of drugs, and other auxiliary materials account for 96%-97.5%. The clonidine transdermal patch is convenient to use; the uniformity of a drug-containing adhesive paste in the production process of the clonidine transdermal patch is improved effectively, and the problems of layering and coating thickness uniformity of the drug-containing adhesive paste in the coating process are solved effectively, and it is ensured that the clonidine transdermal patch is uniform in content and the release behavior conforms to the controlled release characteristic.

Description

technical field [0001] The invention relates to the technical field of clonidine transdermal patch, in particular to a clonidine transdermal patch and a preparation method thereof. Background technique [0002] Clonidine hydrochloride is a central α-adrenergic receptor agonist, which can lower blood pressure and slow down the heart rate by reducing the activity of human sympathetic nerves, and at the same time, it can stimulate the prefrontal cortex by regulating the function of norepinephrine. Restore inhibitory control function, so as to achieve the effect of improving attention and learning ability. [0003] It can be used clinically to treat clinical diseases such as hypertension, migraine, dysmenorrhea and menopausal hyperthermia, Tourette syndrome (voice combined with multiple motor tic disorders), attention deficit hyperactivity disorder (Attention Deficit Hyperactivity Disorder, ADHD), and has very good Efficacy. Transdermal patch refers to the way of drug delivery...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/4168A61P9/04A61P9/12A61J3/04
CPCA61K31/4168A61K9/70A61P9/12A61P9/04A61J3/04
Inventor 王爱爱王峰秦小花范小玲
Owner 范小玲
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