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Tea saponin dispersible tablet, preparation method and applications thereof

A technology of dispersible tablets and tea saponin, which is applied in the direction of chemical instruments and methods, detergent compounding agents, non-ionic surface active compounds, etc., can solve the problem of difficult granulation, unsatisfactory removal of pesticide residues, tea saponin tablets Difficulty and other problems, to achieve the effect of simple preparation process, low hygroscopicity and high content of tea saponin

Active Publication Date: 2020-04-21
GANNAN MEDICAL UNIV
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  • Claims
  • Application Information

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Problems solved by technology

There are two main defects in these products: on the one hand, the removal efficiency of pesticide residues is not ideal; Secondary pollution source
To achieve a better fruit cleaning effect, a certain concentration of tea saponin is required, and a higher content of tea saponin in the tablet is required, but because tea saponin is too hygroscopic, it is difficult to granulate, and a high content of tea saponin is prepared. Tea saponin tablets are difficult

Method used

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  • Tea saponin dispersible tablet, preparation method and applications thereof

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preparation example Construction

[0026] The invention provides a preparation method of tea saponin dispersible tablets. The method comprises: mixing tea saponin, ethanol solution of povidone and optional filler uniformly and then granulating, drying to obtain dry granules, adding disintegration agent, mixed evenly, and tableted to obtain tea saponin dispersible tablets, wherein, by weight, the consumption of each component is: 65-99 parts of tea saponin, 0-14 parts of filler, 0.5-10 parts of povidone , 0.5-15 parts of disintegrant. The dispersible tablet of the present invention can be prepared by adopting the foregoing technical solution, and the disintegration time of the dispersible tablet can be shortened, and the hygroscopicity of the dispersible tablet can be reduced.

[0027] According to a preferred embodiment of the present invention, preferably, the ethanol solution of povidone has a concentration of 1-10% by weight, preferably 3-5% by weight. The dispersible tablet of the present invention can be ...

Embodiment 1

[0041] A tea saponin dispersible tablet, each component in parts by weight: 65 parts of tea saponin, 14 parts of lactose, 5 parts of povidone (povidone K30), 10 parts of croscarmellose sodium . The preparation method is as follows: uniformly mix tea saponin and lactose, add povidone in absolute ethanol solution (3% by weight), prepare soft material by shearing granulation with a wet granulator, and pass through a 20-mesh sieve to obtain wet granules; Under the mixed gas of nitrogen and carbon dioxide (volume ratio is 0.4:1), the first drying is carried out at 40°C for 5h, and then the second drying is carried out at 70°C for 5h under the air atmosphere, and after drying, the granules are passed through a 20-mesh sieve to obtain dry granules; adding croscarmellose sodium to the dry granules, mixing evenly, and pressing into tablets to obtain tea saponin dispersible tablets.

Embodiment 2

[0043] Disclosed is a tea saponin dispersible tablet, which comprises the following components in parts by weight: 99 parts of tea saponin, 1 part of povidone, and 0.5 part of crospovidone (povidone K30). The preparation method is as follows: take the prescribed amount of tea saponin, add povidone in absolute ethanol solution (5% by weight), prepare the soft material by shearing granulation with a wet granulator, and pass through a 10-mesh sieve to obtain wet granules ; Under the mixed gas of nitrogen and carbon dioxide (volume ratio of 0.1:1), carry out the first drying at 60°C for 7h, then carry out the second drying at 80°C for 2h under the air atmosphere, pass through a 10-mesh sieve for granulation, and dry Granules; add crospovidone to the dry granules, mix evenly, and press into tablets to obtain tea saponin dispersible tablets.

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Abstract

The invention relates to a tea saponin dispersible tablet, a preparation method and applications thereof, wherein 100 parts by weight of the dispersible tablet comprise, by weight, 65-99 parts of teasaponin, 0-14 parts of a filler, 0.5-10 parts of povidone and 0.5-15 parts of a disintegrating agent. The tea saponin dispersible tablet provided by the invention has the advantages of simple preparation process, high tea saponin content, quick disintegration when meeting water, low hygroscopicity and the like, and is suitable for production requirements of natural efficient fruit and vegetable cleaning agents.

Description

technical field [0001] The invention relates to a tea saponin dispersible tablet and a preparation method and application thereof. Background technique [0002] Excessive pesticide residues in edible fruits and vegetables have become one of the main problems facing my country's food safety. my country is the world's largest pesticide consumer, with an annual output of 1.9 million tons of pesticides and 600,000 tons of raw materials used. The amount of chemical pesticides used per unit area is 2.5 to 5 times higher than that in the world. The area of ​​crops polluted by residual pesticides reaches 1.2 billion every year. mu. Since most fruits and vegetables are eaten fresh and consumed in large quantities, their pesticide residues are more harmful to the human body. The problem of pesticide residues in fruits and vegetables is related to people's health and should be paid enough attention to. [0003] At present, there are few products sold in China that are specially used t...

Claims

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Application Information

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IPC IPC(8): C11D1/66C11D3/20C11D3/22C11D3/37C11D3/60C11D17/00
CPCC11D1/662C11D3/201C11D3/221C11D3/222C11D3/225C11D3/3776C11D17/0073
Inventor 杨建琼刘海黄浩李林福明良山
Owner GANNAN MEDICAL UNIV
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