Multi-degree-of-freedom self-assembled nanorobot and its manufacturing control method

A nanorobot and control method technology, applied in the field of multi-degree-of-freedom self-assembled nanorobots and their production control, can solve the problem of inability to detect the effective features of single molecules, and achieve instant start-stop, precise control, and high-precision progress. The effect of giving and compensating

Active Publication Date: 2022-05-17
SOUTHEAST UNIV
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Problems solved by technology

[0004] In the existing nanopore single-molecule sensors, the molecules to be detected cannot be stably, continuously and controllably placed in the nanopores, so the sensor faces the problem of not being able to detect enough effective features of single molecules

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  • Multi-degree-of-freedom self-assembled nanorobot and its manufacturing control method

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Embodiment Construction

[0038] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in combination with specific examples and with reference to the accompanying drawings.

[0039] Such as figure 1 As shown, the self-assembled nano-robot of the present invention is composed of micro-nano particles 3 and four deoxyribonucleic acid chains 4, and its specific layout can be found in figure 1 shown. The silicon-based film 1 for the nano-robot to walk is respectively processed with nanoholes 2 and nano-gold electrodes 5 on the vertices of a square on the silicon-based film 1 .

[0040] The ends of the four deoxyribonucleic acid chains 4 are modified with sulfhydryl groups or biotin, while the surface of the micro-nanoparticles 3 is coated with a gold film or streptavidin, through the strong interaction between gold-sulfhydryl bonds or streptavidin and biotin The function binds the deoxyribonucleic a...

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Abstract

The invention relates to a multi-degree-of-freedom self-assembled nano-robot and a production control method thereof. The nano-robot is self-assembled by micro-nano particles and four deoxyribonucleic acid chains through the strong interaction between gold-sulfhydryl bonds or streptavidin and biotin. formed into quadruped nanorobots. By depositing circular gold electrodes on the four vertices of the square on the silicon-based material, four nanoholes are processed on the circular gold electrodes at the same time; the size of the nanoholes makes each nanohole only able to Captures a strand of DNA. Since the nano-gold electrode is connected to an external voltage source, by adjusting the direction and magnitude of the voltage on each nanopore, the electrical and intensity of the charge density on the nanopore can be adjusted, thereby controlling the direction and intensity of the electroosmotic flow through the nanopore, and it is compatible with deoxidation. The electric field force suffered by the ribonucleic acid chain forms a joint or competitive drive, thereby controlling the movement speed and direction of the nanorobot.

Description

technical field [0001] The invention relates to a combined driving technology of electroosmosis and electrophoresis based on nanopores; in particular, it relates to a multi-degree-of-freedom self-assembled nanorobot and a production control method thereof. Background technique [0002] Based on nanopore single-molecule detection technology, the best state of detection is that the molecule to be tested can be stably in the nanopore for a long time, and the molecule to be tested can be controlled to repeatedly enter and exit the nanopore to achieve repeated measurements and reduce the detection error rate. At present, common single-molecule manipulation techniques include atomic force microscopy (AFM), optical tweezers, and magnetic tweezers. For example, the molecule to be tested can be assembled and combined with the AFM probe (or micro-nanoparticle) through the gold-sulfhydryl bond (or the strong interaction of biotin-streptavidin), but the AFM probe cannot scan the nanopor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/00G01Q60/24B82Y40/00
CPCG01N27/00G01Q60/24B82Y40/00
Inventor 司伟陈畅孙倩怡余梦沙菁章寅陈云飞
Owner SOUTHEAST UNIV
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