Hemostatic agent for hemorrhage of jaw central hemangioma, and preparation method and application thereof

A hemostatic agent and hemangioma technology, applied in the field of biomedical engineering, can solve the problems of increased difficulty in treatment, intubation, ineffective embolization, etc., to maintain maxillofacial shape and masticatory function, good fluidity and plasticity , easy cleaning and removal effect

Active Publication Date: 2020-05-05
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, surgical treatment inevitably requires the removal of most of the jawbone together with the teeth, and even the continuity of the mandible cannot be maintained, resulting in local depression deformity and dysfunction after surgery, seriously affecting the quality of life of patients
It has been reported that ligation of the external carotid artery was used to stop bleeding. Not only is the operation ineffective, but it will promote the opening of abnormal collateral circulation. Moreover, it is difficult to implement endovascular embolization after ligation of the external carotid artery, which makes the next step of treatment more difficult.
At present, clinical embolization therapy has opened up a new way for emergency hemostasi

Method used

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preparation example Construction

[0018] The invention provides a kind of preparation method of chitosan-based rapid hemostatic agent, comprising the following steps:

[0019] 1) Add chitosan powder and organic weak acid to the organic alcohol, react at 40-50°C for 3-5 hours, filter the filtrate, rinse with organic alcohol, and dry at 40-50°C to obtain chitosan Weak salt of sugar;

[0020] 2) Mixing the weak salt of chitosan and carboxymethyl chitosan evenly to obtain a hemostatic agent, the content of carboxymethyl chitosan in the hemostatic agent is 8-17wt%.

[0021] Specifically, the present invention firstly adds chitosan powder and organic weak acid to the organic alcohol in sequence, reacts at 40-50°C for 3-5h, filters the filtrate, rinses with organic alcohol, and bakes at 40-50°C. Dry to obtain chitosan weak acid salt. In the present invention, the organic alcohol used is preferably one or both of ethanol and isopropanol, and the concentration is commercially available. The organic weak acid used is...

Embodiment 1

[0027] (1) Add 10g chitosan powder (deacetylation degree is 80%, molecular weight is 300KDa, viscosity is 60cP, mesh number is 50 mesh) in 100mL ethanol, then add 5g citric acid, react at 40 DEG C for 5h, Filtration yielded a precipitate.

[0028] (2) The precipitate was washed twice with ethanol, and dried at 40° C. to obtain 12 g of chitosan citrate.

[0029] (3) 12g of chitosan citrate and 1g of carboxymethyl chitosan were evenly mixed to obtain the hemostatic agent of this embodiment.

Embodiment 2

[0031] (1) Add 15g chitosan powder (deacetylation degree is 80%, molecular weight is 300KDa, viscosity is 60cP, mesh size is 50 mesh) in 100mL isopropanol, then add 8g lactic acid, react at 40°C for 4h , filtered to obtain a precipitate.

[0032] (2) The precipitate was rinsed twice with isopropanol, and dried at 40° C. to obtain 18 g of chitosan lactate.

[0033] (3) 18g of chitosan lactate and 2g of carboxymethyl chitosan were evenly mixed to obtain the hemostatic agent of this embodiment.

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Abstract

The invention relates to the field of biomedical engineering, and discloses a hemostatic agent for hemorrhage of jaw central hemangioma, and a preparation method and application thereof. Chitosan powder and organic weak acid are added into organic alcohol for reaction to prepare chitosan weak acid salt; and the chitosan weak acid salt and carboxymethyl chitosan are proportionally mixed to obtain the hemostatic agent disclosed by the invention. The hemostatic agent has high fluidity and plasticity, is applied to the hemostasis of hemorrhage of jaw central hemangioma and can fast reach a hemorrhagic spot of the jaw central hemangioma; tissues are not irritated; no harm is generated on the tissues; the bacterial growth can be inhibited; the cross infection is avoided; the cleaning and the clearing are easy; and the hemostatic agent is a safe and extremely effective hemostatic agent for treating massive hemorrhage of the jaw central hemangioma, and is worthy of clinical popularization. Meanwhile, the hemostatic agent can also be used as a hemostatic agent for hemorrhagic spots of tissue lacunas of special structures.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a hemostatic agent for hemangioma bleeding in the center of the jaw, a preparation method and application thereof. Background technique [0002] Central hemangioma of the jaw belongs to true hemangioma. It is rare and hidden clinically, but it is a potentially dangerous disease, and it is rarely diagnosed before symptoms. Central hemangioma of the jaw is more common in children and adolescents, and often causes massive hemorrhage during routine tooth extraction in outpatient clinics. As a result, death is not uncommon. If you don’t know about it, you have to operate or extract the affected area of ​​the tooth rashly, which can cause fatal hemorrhage. Therefore, timely and effective hemostasis for the patient at the first scene is crucial to rescuing the patient, making a further diagnosis, and formulating a reasonable treatment plan to cure the patient. [0003] Sudden hemo...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61P7/04
CPCA61K31/722A61P7/04A61K2300/00
Inventor 杨宇民朱江王勇军张鲁中李贵才赵亚红凌珏杨鹏翔
Owner NANTONG UNIVERSITY
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