Hemostatic agent for hemorrhage of jaw central hemangioma, and preparation method and application thereof

Abstract

The invention relates to the field of biomedical engineering, and discloses a hemostatic agent for hemorrhage of jaw central hemangioma, and a preparation method and application thereof. Chitosan powder and organic weak acid are added into organic alcohol for reaction to prepare chitosan weak acid salt; and the chitosan weak acid salt and carboxymethyl chitosan are proportionally mixed to obtain the hemostatic agent disclosed by the invention. The hemostatic agent has high fluidity and plasticity, is applied to the hemostasis of hemorrhage of jaw central hemangioma and can fast reach a hemorrhagic spot of the jaw central hemangioma; tissues are not irritated; no harm is generated on the tissues; the bacterial growth can be inhibited; the cross infection is avoided; the cleaning and the clearing are easy; and the hemostatic agent is a safe and extremely effective hemostatic agent for treating massive hemorrhage of the jaw central hemangioma, and is worthy of clinical popularization. Meanwhile, the hemostatic agent can also be used as a hemostatic agent for hemorrhagic spots of tissue lacunas of special structures.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a hemostatic agent for hemangioma bleeding in the center of the jaw, a preparation method and application thereof. Background technique [0002] Central hemangioma of the jaw belongs to true hemangioma. It is rare and hidden clinically, but it is a potentially dangerous disease, and it is rarely diagnosed before symptoms. Central hemangioma of the jaw is more common in children and adolescents, and often causes massive hemorrhage during routine tooth extraction in outpatient clinics. As a result, death is not uncommon. If you don’t know about it, you have to operate or extract the affected area of ​​the tooth rashly, which can cause fatal hemorrhage. Therefore, timely and effective hemostasis for the patient at the first scene is crucial to rescuing the patient, making a further diagnosis, and formulating a reasonable treatment plan to cure the patient. [0003] Sudden hemo...

AI Technical Summary

Problems solved by technology

However, surgical treatment inevitably requires the removal of most of the jawbone together with the teeth, and even the continuity of the mandible cannot be maintained, resulting in local depression deformity and dysfunction after surgery, seriously affecting the quality of life of patients

It has been reported that ligation of the external carotid artery was used to stop bleeding. Not only is the operation ineffective, but it will promote the opening of abnormal collateral circulation. Moreover, it is difficult to implement endovascular embolization after ligation of the external carotid artery, which makes the next step of treatment more difficult.

At present, clinical embolization therapy has opened up a new way for emergency hemostasis. By using arterial retrograde intubation, embolization is performed with its own muscle or various microspheres and other materials. Embolization, on the contrary, may wrongly embolize important blood vessels, causing serious complications and limiting its clinical use

[0004] The main reasons for the difficulty in hemostasis of the central vascular bleeding of the jaw are the following two points: First, the bleeding point of the central vascular of the jaw is often hidden in the alveolar fossa, where the space structure is small and irregular, and the existing hemostatic materials cannot Quickly reach the bleeding point; Second, after tooth extraction, bleeding from central blood vessels of the jaw is often in the form of jet bleeding