Processing method and application for wine-processed fructus corni

A technology for wine cornus and yellow rice wine, which is applied to the wine production method and application field of Cornus officinalis, and can solve the problems of not considering the content of morroniside, not providing the drying process parameters of the product with added alcohol, and not considering the situation of 5-hydroxymethylfurfural, etc. , to increase production efficiency, reduce labor and energy costs, and shorten drying time

Inactive Publication Date: 2020-05-15
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the processing technology of wine cornus is mainly based on wine steaming, such as: Cornus officinalis decoction pieces and its processing method (CN109481489 A) provides a method for removing the core of fresh cornus and making wine. The establishment of process parameters depends on the content of loganin As an indicator, the higher content of morroniside and the 5-hydroxymethylfurfural produced in the processing process were not considered; a fingerprint establishment method for controlling the processing parameters of wine cornus (CN 109975442 A) provides The content determination method of loganin, morroniside, gallic acid, protocatechuic acid and 5-hydroxymethylfurfural in the process, and according to this method, the preparation time, braising time and steaming time of Cornus officinalis were investigated. However, it did not provide the amount of alcohol added, the drying process parameters of the steamed product, etc.

Method used

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  • Processing method and application for wine-processed fructus corni
  • Processing method and application for wine-processed fructus corni
  • Processing method and application for wine-processed fructus corni

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 The wine stewing process optimization experiment of Cornus officinalis.

[0029] 1. The preparation method of cornus officinalis stewed in wine-the experiment of adding alcohol.

[0030] A method for preparing dogwood wine stew, comprising the following steps.

[0031] (1) Take 5 parts of cornus cornus, 20 g each, add rice wine in proportions of 100:10, 100:20, 100:30, 100:40, and 100:50, and simmer until the wine is exhausted. In a closed container, stew in a pot for 4 hours, take it out, spread it on an enamel plate, and dry it at 50°C.

[0032] (2) Crush the obtained wine cornus, pass through a No. 4 sieve, take 0.1 g of each powder, accurately weigh, accurately add 25 mL of 80% methanol, ultrasonically extract for 20 min, take out, filter, take the subsequent filtrate, pass through 0.45 µm micro pore filter membrane, draw 10 µL respectively and inject it into the high-performance liquid chromatograph, measure the chromatographic peak areas of 5-hydroxyme...

Embodiment 2

[0053] Example 2 Comparison of the quality of wine cornus stewed in wine and steamed in wine.

[0054] A method for preparing dogwood wine stew, comprising the following steps.

[0055] Take 2 portions of clean cornus, 50 g each, add rice wine at a ratio of 100:30, simmer until the wine is exhausted, put in a closed container, stew in a pot for 6 hours, take it out, put it on an enamel plate and lay it flat, 50 ℃ dry 4h.

[0056] A preparation method of cornus officinalis by wine steaming, comprising the following steps.

[0057] Take 2 portions of clean cornus, 50 g each, add rice wine at a ratio of 100:30, simmer until the wine is completely absorbed, steam in a pot for 6 hours, take it out, spread it on an enamel plate, and dry at 50°C 4h.

[0058] Measure the weight of raw materials and products of wine cornus obtained by stewing and steaming respectively, and calculate the product yield; and determine the content of 5-hydroxymethylfurfural, morroniside, loganin and wat...

Embodiment 3

[0062] Example 3 Pharmacological research experiment of wine cornus - the mouse model of kidney yin deficiency was reproduced by using hydrocortisone modeling method.

[0063] Take 30 mice and randomly divide them into a blank group, a model group, and a wine stewed product group in Example 2, 10 in each group, and inject hydrocortisone subcutaneously at a dose of 50 mg / kg. Once a day for 5 consecutive days, the model of kidney yin deficiency was replicated. The blank group and the model group were given pure water by intragastric administration, and the wine stewed product group was given the wine cornus water extract by intragastric administration. Take 20 g of the wine stewed product in Example 2 and add 10 times the amount of pure water to soak for 0.5 h, and heat and reflux extraction for 3 times , 1 h / time, filter and combine the filtrates to prepare a concentration of about 156 mg·ml -1 The dosing solution is calculated by gavage of 0.1ml per 10 g of body weight, and t...

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Abstract

The invention relates to the technical field of traditional Chinese medicine processing, in particular to a processing method and an application for wine-processed fructus corni. The preparation method for the wine-processed fructus corni comprises the following steps: screening and removing residual stems and kernels in a fructus corni medicinal material so as to obtain fructus corni pulp; addingyellow rice wine, carrying out uniform stirring, and sealing a container until the yellow rice wine is completely absorbed; putting processed fructus corni pulp into a pot, and carrying out stewing out of water; and drying the stewed wine-processed fructus corni. According to the invention, the measuring indexes, namely the total amount of morroniside and loganin, the content of a water-soluble extract and water specified in the pharmacopeia are taken as main investigation indexes of the wine-processed fructus corni prepared by using the processing method provided by the invention; the content of a byproduct, namely 5-hydroxymethylfurfural generated in the processing process is comprehensively considered; and technological parameters of the processing process are optimized. Thus, the drying time of a product is remarkably shortened; the finished product yield of the product is increased; the cost of labor and energy is reduced for production enterprises; the output is increased; and the production benefits are increased. The invention discloses the application of the wine-processed fructus corni in preparation of a medicine for treating deficiency of kidney-yin.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine processing, and in particular relates to a wine-making method and application of Cornus officinalis. Background technique [0002] Cornus officinalis Cornus officinalis The dried and mature pulp of Sieb.et Zucc. has the effects of nourishing the liver and kidney, and reducing astringency and solidification. The types of decoction pieces used clinically include cornus and wine cornus. Among them, cornus is longer than astringent and solid, and its tonic effect is enhanced after brewing. It is mostly used in tonic prescriptions, such as Jinkuishenqi pills and Liuweidihuang pills. Wine cornus is the most commonly used variety in clinical decoction pieces. The Pharmacopoeia stipulates that the processing method of wine cornus is "take clean cornus, stew or steam according to the method of wine stewing or wine steaming (general rule 0213) until the wine is completely absorbed; t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/40A61P13/12A61K131/00
CPCA61K36/40A61K2236/10A61K2236/13A61K2236/17A61P13/12
Inventor 王巍鞠成国王雪纯张强杜春洁
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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