Traditional Chinese medicine composition capable of resisting novel coronavirus SARS-Cov-2 as well as preparation method and application of traditional Chinese medicine composition

A sars-cov-2, coronavirus technology, applied in antiviral agents, drug combinations, medical preparations containing active ingredients, etc., can solve problems such as life and health hazards of patients

Inactive Publication Date: 2020-05-15
JIANGSU HEALTH VOCATIONAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no effective treatment drug for the new coronavirus SA

Method used

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  • Traditional Chinese medicine composition capable of resisting novel coronavirus SARS-Cov-2 as well as preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition capable of resisting novel coronavirus SARS-Cov-2 as well as preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition capable of resisting novel coronavirus SARS-Cov-2 as well as preparation method and application of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. A traditional Chinese medicine composition with anti-new coronavirus SARS-Cov-2 effect, which is made of the following raw materials in parts by weight:

[0034] 40 grams of Daqingye, 40 grams of wild chrysanthemum, 20 grams of coptis, 30 grams of custard apple seeds, 20 grams of Huoxiang, 20 grams of herb, 20 grams of Bupleurum, 2 grams of artificial bezoar, 20 grams of Houttuynia cordata, 5 grams of dandelion root , Honeysuckle 30 grams, Forsythia 30 grams, Scutellaria baicalensis 20 grams, Shegan 20 grams, Salvia miltiorrhiza 15 grams, Chuanbei 15 grams, Tianshan Saussurea 10 grams, Astragalus 60 grams, Cordyceps 20 grams, Codonopsis 20 grams, licorice 30 grams.

[0035] 2. The preparation method of the Chinese medicine composition with anti-new coronavirus SARS-Cov-2 effect, comprising the following steps:

[0036] (1) Take 20 grams of Huoxiang, 20 grams of Atractylodes atractylodes and 20 grams of Bupleuri in parts by weight, add 10 times the amount of water, ex...

Embodiment 2

[0041] 1. A traditional Chinese medicine composition with anti-new coronavirus SARS-Cov-2 effect, which is made of the following raw materials in parts by weight:

[0042]20 grams of Daqingye, 10 grams of wild chrysanthemum, 5 grams of coptis, 10 grams of custard apple seeds, 10 grams of Huoxiang, 10 grams of herb, 10 grams of Bupleurum, 1 gram of artificial bezoar, 10 grams of Houttuynia cordata, 5 grams of dandelion root , Honeysuckle 10 grams, Forsythia 10 grams, Scutellaria baicalensis 10 grams, Shegan 10 grams, Salvia miltiorrhiza 5 grams, Chuanbei 5 grams, Tianshan snow lotus 5 grams, Astragalus 30 grams, Cordyceps 5 grams, Codonopsis 10 grams, licorice 10 grams.

[0043] 2. The preparation method of the Chinese medicine composition with anti-new coronavirus SARS-Cov-2 effect, comprising the following steps:

[0044] (1) Take 10 grams of Huoxiang, 10 grams of Atractylodes atractylodes, and Bupleurum 10 grams in parts by weight, add 12 times the amount of water, extract b...

Embodiment 3

[0048] Example 3 In vitro antiviral activity experiment of Chinese medicine composition on novel coronavirus SARS-Cov-2

[0049] 1. Experimental samples

[0050] The samples of the mixture prepared in Example 1 and Example 2 of the present invention are composed of artificial bezoar, Cordyceps sinensis, step (1) volatile oil clathrate, step (2) extract and step (3) extract.

[0051] 2. Experimental method

[0052] 1.1, L929 cell (fibroblast) toxicity test (MTT method)

[0053] The monolayer cells of the 96-well plate were washed once with PBS, the supernatant was discarded, and 100 μL of 4-fold serially diluted mixture samples prepared in Example 1 and Example 2 were added to each well. Add an equal volume of culture medium to each well of the blank control group and the normal cell group, at 34°C, 5% CO 2 Cultivate under conditions for 2-5d. Then 20 μL of MTT solution with a concentration of 5 mg / mL was added to each well, and the incubation was continued for 4 h. Discar...

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Abstract

The invention discloses a traditional Chinese medicine composition capable of resisting novel coronavirus SARS-Cov-2 and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from folium isatidis, flos chrysanthemi indici, rhizoma coptidis, cherimoya seeds, agastache rugosus, rhizoma atractylodis, radix bupleuri, calculus bovis factitius, herba houttuyniae, dandelion root, honeysuckles, fructus forsythia, radix scutellariae, rhizoma belamcandae, salvia miltiorrhiza, bulbus fritillariae cirrhosae, saussurea involucrate, radix astragali, cordyceps militaris, radix codonopsis and liquorice. By carrying out screening in a large number of experiments according to pathogenic characteristics of the novel coronavirus SARS-Cov-2 and a viscera screening composition of concurrent injury, researches on in vitro safety and drug efficacy of in vitro novel coronavirus show that the traditional Chinese medicine composition disclosed by the invention has a remarkable inhibition effect to the novel coronavirus SARS-Cov-2. Clinical experimental observation shows that the traditional Chinese medicine composition is capable of remarkably improving pneumonia symptoms concurrent with the novel coronavirus SARS-Cov-2.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition capable of resisting novel coronavirus SARS-Cov-2, a preparation method and application thereof. Background technique [0002] On February 11 this year, the International Committee on Taxonomy of Viruses (ICTV) announced the official name of the new coronavirus as severe acute respiratory syndrome coronavirus 2 (severe acute respiratory syndrome coronavirus 2, referred to as SARS-CoV-2). The virus is a new type of coronavirus strain, which is highly contagious and has a high mortality rate without special drug treatment. The virus is transmitted mainly through respiratory droplets and contact transmission. The most common symptoms of pneumonia infection caused by the new coronavirus are accompanied by fever, fatigue, dry cough, and difficulty in breathing. Severe symptoms include coagulation dysfunction, ...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61P31/14A61P11/00A61P13/12A61P1/16A61K35/413
CPCA61K35/413A61K36/068A61K36/185A61K36/195A61K36/233A61K36/284A61K36/285A61K36/287A61K36/288A61K36/315A61K36/344A61K36/355A61K36/481A61K36/484A61K36/532A61K36/537A61K36/539A61K36/634A61K36/704A61K36/718A61K36/78A61K36/855A61K36/88A61K36/8966A61K2236/331A61K2236/333A61K2236/39A61P1/16A61P11/00A61P13/12A61P31/14A61K2300/00
Inventor 张宁杨海军
Owner JIANGSU HEALTH VOCATIONAL COLLEGE
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