Method for extracting oryzanol with plurality of solvents

An oryzanol extraction technology, applied in the direction of steroids, organic chemistry, etc., can solve problems such as the need to improve the advance efficiency, large usage, and the environment, and achieve the effects of saving solvent consumption, reducing residues, and improving extraction efficiency

Active Publication Date: 2020-05-19
HANGZHOU YIPIN XINWUFENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, benzene was used as a solvent in this study, and the amount used was relatively large, which caused serious environmental problems in the large-scale production process
In addition, the advance efficiency of this method still needs to be improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 100 grams of rice bran oil soapstock (the oryzanol content is 15% after testing), add 800 ml of ether and 600 ml of 40% isopropanol, stir to dissolve, then add 1 ml of 30% sodium hydroxide, and use The pH value of the feed liquid measured by precision test paper was 8.3. After stirring for 5 minutes, the layers were left to stand to obtain 900 ml of ether feed liquid in the upper layer. The lower layer was washed twice with 700 ml of diethyl ether, placed separately, and used as diethyl ether. 700 milliliters of the lower layer of feed solution after the second washing were removed to recover the solvent.

[0030] Add 900 milliliters of 50% isopropanol to the upper layer ether feed solution, stir evenly, add 7 milliliters of 30% sodium hydroxide, the pH value of the feed solution is 13, and then stand for stratification to obtain 950 milliliters of the lower layer feed solution , the upper ether layer was washed twice with 900 ml of 50% isopropanol, then the solv...

Embodiment 2

[0034] 2. 200 grams of rice bran oil soapstock, whose oryzanol content is 15% after testing, add 1600 ml of ether and 1200 ml of 40% isopropanol, stir to dissolve, then add 2 ml of 30% sodium hydroxide, and use a precision The pH value of the feed solution measured by the test paper was 8. After stirring for 5 minutes, the layers were left to stand to obtain 1700 ml of the upper layer ether feed solution. The lower layer was washed twice with 1600 ml of diethyl ether, placed separately, and used as diethyl ether. 1100 milliliters of the lower layer feed solution after the second washing was removed to recover the solvent.

[0035]Add 1700 milliliters of 50% isopropanol to the upper layer ether feed liquid, stir evenly, add 15 milliliters of 30% sodium hydroxide, and record the pH value of the feed liquid to be 13, then leave it to stand for stratification to obtain 1750 milliliters of the lower layer feed liquid , the upper ether layer was washed twice with 1600 ml of 50% iso...

Embodiment 3

[0039] 300 grams of rice bran oil soapstock, its oryzanol content is 13% after testing, add 2400 ml of ether and 1800 ml of 40% isopropanol, stir to dissolve, then add 3 ml of 30% sodium hydroxide, test with precision test paper The pH value of the obtained feed solution was 8.0. After stirring for 7 minutes, the mixture was allowed to stand and separated to obtain 2500 ml of ether feed solution in the upper layer. The lower layer was washed twice with 2400 ml of diethyl ether, placed separately, and used as diethyl ether. 1600 milliliters of the lower layer feed solution after the secondary washing was removed to recover the solvent.

[0040] Add 2500 milliliters of 50% isopropanol to the upper layer ether feed liquid, stir evenly, add 45 milliliters of 30% sodium hydroxide, and record the pH value of the feed liquid to be 13, then leave it to stand for stratification to obtain 2550 ml of the lower layer feed liquid , the upper ether layer was washed twice with 2400 ml of 50...

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PUM

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Abstract

The invention relates to the technical field of oryzanol extraction, and in particular to a method for extracting oryzanol with a plurality of solvents. The method comprises the steps of extraction, refining, decolorization and crystallization, and is characterized in that the extraction step comprises the steps of performing primary extraction on the rice bran oil soapstock by using diethyl etherand 30-50% by volume of isopropanol as solvents, and then performing secondary extraction on an obtained upper-layer feed liquid by using 40-60% by volume of isopropanol to obtain an oryzanol crude product. According to themethod disclosed by the invention, the plurality ofsolvents are adopted for twice extraction, and oryzanol in the raw material rice bran oil soapstock can be fully extracted, so that residues of oryzanol in the raw material are reduced, and the extraction efficiency of oryzanol is greatly improved (up to 85% or above).

Description

technical field [0001] The invention relates to the technical field of oryzanol extraction, and more specifically relates to a method for extracting oryzanol with multiple solvents. Background technique [0002] Oryzanol exists in rice oil (rice bran oil), which is a mixture of ferulic acid esters mainly composed of triterpene (en) alcohols. It mainly acts on the autonomic nervous system and endocrine center of the diencephalon, can adjust autonomic nervous function, reduce endocrine balance disorders, and improve symptoms of mental and nervous disorders. At the same time, it also has various physiological functions such as reducing blood lipids, reducing liver lipids, preventing lipid oxidation, and anti-oxidation. In addition, it also has the effect of resisting arrhythmia, which can reduce the excitability of myocardial muscle by regulating the function of autonomic nerves. The lipid-lowering effect of oryzanol can also improve the blood supply of the myocardium and pla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J53/00
CPCC07J53/001C07J53/004
Inventor 蒋伟行赵万颖
Owner HANGZHOU YIPIN XINWUFENG PHARMA CO LTD
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