Preparation method of chitosan/polyvinyl alcohol hydrogel dressing

A polyvinyl alcohol and polyvinyl alcohol solution technology, applied in medical science, bandages, etc., can solve the problems of poor hydrogel strength, affecting wound healing, human tissue damage, etc., to overcome the strength difference, promote rapid healing, good The effect of mechanical properties

Pending Publication Date: 2020-06-05
河南省科学院同位素研究所有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above technical methods have successfully obtained chitosan hydrogel dressings, but toxic reagents such as glyoxal and glutaraldehyde are used as cross-linking agents. Even if a small amount of this toxic cross-linking agent remains, it will still cause varying degrees of damage to human tissues. , affect the healing of the wound; and the irradiation method will lead to the degradation of chitosan in the chitosan hydrogel dressing under the condition of high-energy ray irradiation and the problem of poor hydrogel strength

Method used

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  • Preparation method of chitosan/polyvinyl alcohol hydrogel dressing
  • Preparation method of chitosan/polyvinyl alcohol hydrogel dressing
  • Preparation method of chitosan/polyvinyl alcohol hydrogel dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Weigh chitosan powder with a relative molecular weight of 5w, place it in an acetic acid solution with a mass percent content of 1%, and stir the solution to form a chitosan solution with a mass volume concentration of 1%. Weigh 10 g of polyvinyl alcohol, add it to 90 ml of distilled water, and stir at 85°C for 3 hours until a clear and transparent polyvinyl alcohol solution with a mass fraction of 10% is formed. Mix the chitosan solution and polyvinyl alcohol solution according to the volume ratio of 1:1, stir evenly, and let it defoam under vacuum; then pour the chitosan / polyvinyl alcohol mixed solution into the mold, freeze and thaw twice process it after 60 Co gamma rays were irradiated, and the radiation absorbed dose was 30kGy, and a chitosan / polyvinyl alcohol hydrogel dressing was obtained.

[0032] The appearance diagram, mechanical performance diagram, and antibacterial performance diagram of the chitosan / polyvinyl alcohol hydrogel dressing obtained in the pre...

Embodiment 2

[0035] Weigh chitosan powder with a relative molecular weight of 5w, place it in an acetic acid solution with a mass percent content of 1%, and stir the solution to form a chitosan solution with a mass volume concentration of 1%. Weigh 10 g of polyvinyl alcohol, add it to 90 ml of distilled water, and stir at 85°C for 3 hours until a clear and transparent polyvinyl alcohol solution with a mass fraction of 10% is formed. Mix the chitosan solution and polyvinyl alcohol solution according to the volume ratio of 1:3, stir evenly, and let it defoam under vacuum; then pour the chitosan / polyvinyl alcohol mixed solution into the mold, freeze and thaw once process it after 60 Co gamma rays were irradiated, and the radiation absorbed dose was 30kGy, and a chitosan / polyvinyl alcohol hydrogel dressing was obtained.

[0036] The chitosan / polyvinyl alcohol hydrogel dressing swelling ratio that the present embodiment obtains is 153%.

Embodiment 3

[0038] Weigh chitosan powder with a relative molecular weight of 1-2w, place it in an acetic acid solution with a mass percent content of 1%, and stir the solution to form a chitosan solution with a mass volume concentration of 2%. Weigh 10 g of polyvinyl alcohol, add it to 90 ml of distilled water, and stir at 85°C for 3 hours until a clear and transparent polyvinyl alcohol solution with a mass fraction of 10% is formed. Mix the chitosan solution and polyvinyl alcohol solution according to the volume ratio of 1:1, stir evenly, and let it defoam under vacuum; then pour the chitosan / polyvinyl alcohol mixed solution into the mold, freeze and thaw twice After processing, the hydrogel belt mold 60 Co gamma rays were irradiated, and the radiation absorbed dose was 40kGy, and a chitosan / polyvinyl alcohol hydrogel dressing was obtained.

[0039] The chitosan / polyvinyl alcohol hydrogel dressing swelling ratio that the present embodiment obtains is 192%.

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Abstract

The invention discloses a preparation method of a chitosan/polyvinyl alcohol hydrogel dressing, and belongs to the technical field of polymer materials. The preparation method comprises the followingsteps: (1) obtaining a chitosan/polyvinyl alcohol solution; and (2) carrying out freeze thawing and an irradiation treatment in sequence to obtain the chitosan/polyvinyl alcohol hydrogel dressing. Thesynthesized chitosan/polyvinyl alcohol hydrogel can obviously improve the appearance and mechanical properties of hydrogel, the prepared dressing does not need a cross-linking agent or an initiator,the forming and sterilization of the hydrogel dressing are completed at the same time, and the hydrogel has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a method for preparing a hydrogel dressing, in particular to a method for preparing a chitosan / polyvinyl alcohol hydrogel dressing. Background technique [0002] As a natural alkaline polysaccharide, chitosan (CS) has excellent biocompatibility; when its molecular weight is within a certain range, it has good antibacterial and blood coagulation functions, and is suitable for local treatment of wounds, and its price is low. One of the ideal materials for dressing. At present, the commonly used preparation methods of chitosan hydrogel dressings include chemical methods, radiation methods, and physical methods. The freeze-thaw method is an effective method for preparing polyvinyl alcohol hydrogel reported by Peppas the earliest. The hydrogel produced by this method has the advantages of good elasticity and high mechanical strength, but this hydrogel is a physi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/28C08L29/04C08L5/08A61L26/00
CPCC08J3/075C08J3/28A61L26/008A61L26/0052C08J2329/04C08J2405/08C08J2305/08C08J2429/04C08L5/08C08L29/04
Inventor 杨明成郭文慧刘树博张本尚刘文涛张宏娜张修强田青亮王允赵惠东王晓慧张振亚樊红丽刘克波
Owner 河南省科学院同位素研究所有限责任公司
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