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Application of atrial natriuretic peptide in preparation of medicine for treating inflammatory bowel diseases

An atrial natriuretic peptide, inflammatory bowel disease technology, applied in the field of biomedicine, can solve problems such as inability to use IBD, metabolic disorders, maintenance therapy, etc.

Active Publication Date: 2020-06-12
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although glucocorticoids can quickly induce remission and are cheap, but due to the simultaneous regulation of growth, development, metabolism and other physiological functions, long-term use has many side effects, which can easily cause gastrointestinal bleeding, osteoporosis, metabolic disorders, etc., and cannot be used for IBD maintenance. treat

Method used

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  • Application of atrial natriuretic peptide in preparation of medicine for treating inflammatory bowel diseases
  • Application of atrial natriuretic peptide in preparation of medicine for treating inflammatory bowel diseases
  • Application of atrial natriuretic peptide in preparation of medicine for treating inflammatory bowel diseases

Examples

Experimental program
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Effect test

Embodiment 1

[0019] Example 1 Therapeutic Effect on Mice Ulcerative Colitis

[0020] Material:

[0021] A. Mice: C57BL / 6J breed mice (purchased from Beijing Weitong Lihua Company), bred to 20-22g under SPF environment, about 8 weeks old.

[0022] B. Human atrial natriuretic peptide ANP (purchased from Tocris Bioscience, UK), amino acid sequence Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly - Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr, molecular weight 3080.46 Da; purity 95.8%.

[0023] Method and Results:

[0024] 1. Construction of dextran sodium sulfate (DSS)-induced colitis mouse model and the intervention of ANP recombinant protein.

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Abstract

The invention relates to application of atrial natriuretic peptide in preparation of a medicine for treating inflammatory bowel diseases. According to the application of the atrial natriuretic peptidein preparation of the medicine for treating inflammatory bowel diseases, the inflammatory bowel diseases comprise ulcerative colitis, Crohn's disease and amorphous colitis. The atrial natriuretic peptide has no adverse effect on normal cells, has no toxic or side effect and can effectively relieve colonic inflammation of colitis and reduce secretion of inflammatory cytokines of colonic tissues.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular to the application of atrial natriuretic peptide in the preparation of anti-inflammatory drugs. Background technique [0002] Inflammatory bowel disease (IBD) mainly includes ulcerative colitis (UC) and Crohn's disease (CD), the breakthrough of its treatment is inseparable from the development of new drugs. [0003] The main treatment drugs for IBD include 5-aminosalicylic acid, glucocorticoids, immunosuppressants and biologics, which induce and maintain disease remission through immune modulation. In recent years, drug research and development has mainly focused on biological agents and small molecule targeted drugs, but research on hormone drugs is relatively lacking. Although glucocorticoids can quickly induce remission and are cheap, but due to the simultaneous regulation of growth, development, metabolism and other physiological functions, long-term use has many side effects, which ...

Claims

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Application Information

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IPC IPC(8): A61K38/22A61P1/00A61P29/00A61P1/04
CPCA61K38/2242A61P1/00A61P29/00A61P1/04
Inventor 陈超越付妤全润泽张颖赵溪
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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