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Small portable mass spectrum on-site rapid detection method for fentanyl substances

A detection method and a portable technology, which is applied in the field of rapid on-site detection of small portable mass spectrometers for fentanyl-like substances, can solve the problems of short onset time, respiratory depression, death, etc., and achieve the effect of short detection time

Active Publication Date: 2020-06-12
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Fentanyl-like substances have powerful analgesic effects, short onset time, and are easy to obtain, but excessive use can easily lead to physical and mental dependence, respiratory depression and death
In recent years, the abuse of fentanyl and fentanyl analogues has continued to occur around the world, causing a large number of casualties and seriously endangering social stability

Method used

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  • Small portable mass spectrum on-site rapid detection method for fentanyl substances
  • Small portable mass spectrum on-site rapid detection method for fentanyl substances
  • Small portable mass spectrum on-site rapid detection method for fentanyl substances

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Embodiment Construction

[0030] 1. Instruments and materials

[0031] Miniβ small portable mass spectrometer: Beijing Qingpu Technology Co., Ltd. 3-nitrobenzonitrile, English name 3-nitrobenzonitrile, CAS No. 619-24-9, molecular formula C 7 h 4 N 2 o 2 , the average molecular weight is 148.12g / mol.

[0032] 2. Detection and analysis method

[0033] A small-scale portable mass spectrometry on-site rapid detection method for fentanyl substances in suspicious powder or liquid, comprising the following steps:

[0034] (1) Selection of point template: select a triangular paper base as the point sample, the side length of the triangular paper base is 1 cm, and the height is 1.5 cm;

[0035] (2) Loading sample: Load 1-3 microliters of liquid sample (or 1-3 micrograms of powder sample) onto the tip of the triangular paper base, and drop 5-10 microliters of 3-nitrobenzonitrile solution on the sample to form a mixture , stand still for 10-30 seconds to form a mixture of sample and 3-nitrobenzonitrile to ...

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Abstract

The invention discloses a small portable mass spectrum on-site rapid detection method for fentanyl substances. The method comprises the following steps: (1) selecting a point template; (2) loading a sample: dropwise adding the sample and an acetonitrile solution of 3-nitrobenzonitrile on the sample application plate to form a crystal mixture; and (3) carrying out analysis and detection: setting parameters of the small portable mass spectrometer, tightly attaching the crystal mixture on the sample application plate to a sample inlet of the small portable mass spectrometer, and ionizing the sample to complete detection and analysis of fentanyl substances in the sample. The small portable mass spectrum detection method for fentanyl substances is established, does not need an extraction solvent, voltage, laser or gas, is simple and rapid, and is suitable for on-site rapid detection of fentanyl substances.

Description

technical field [0001] The invention relates to a detection method of chemical substances, in particular to a small-scale portable mass spectrometry field rapid detection method for fentanyl substances. Background technique [0002] Fentanyl (Fentanly) is an opioid receptor agonist synthesized by Belgian scientist Paul Janssen in 1960, and its chemical name is N-[1-(2-phenylethyl)-4-piperidinyl]-N- Phenylpropanamide, the analgesic effect is 80 times that of morphine, and it is often used clinically for intraoperative and postoperative anesthesia. Fentanyl analogues are formed by modifying three parts: phenylalkyl group, piperidinyl ring, and propylalkylamide. The types include remifentanil, carfentanil, sufentanil, etc. The analgesic effect is stronger than fentanyl. For example, the analgesic effect of carfentanil is 100 times that of fentanyl and 10,000 times that of morphine. [0003] Fentanyl has a powerful analgesic effect, a short onset time, and is very easy to obta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62
CPCG01N27/62H01J49/0013G01N33/9486H01J49/0031
Inventor 马强郭项雨白桦李文涛
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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