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Endoluminal device and polymer

A composition and prepolymer technology, which can be applied in the direction of human tubular structure devices, surgical adhesives, blood vessels, etc., can solve problems such as short recovery period

Pending Publication Date: 2020-06-12
ENDOLOGIX LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The recovery period for successful endovascular surgery is much shorter than for open surgery

Method used

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  • Endoluminal device and polymer
  • Endoluminal device and polymer
  • Endoluminal device and polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0128] Embodiment 1: the preparation of organogel

[0129] Organogels are prepared by mixing together two solutions, C1 and C2. First, separate C1 and C2 solutions are prepared by mixing together appropriate amounts of the appropriate ingredients until the solutions are uniform and any solid material that was part of the formulation is completely dissolved. Then add C1 to C2 (or C2 to C1) and mix the two components together under constant stirring for 5 to 15 seconds. Alternatively, fill two barrel cartridges, barrel 1 and barrel 2, with C1 and C2 respectively, and mix the solutions together during dispensing of the solutions into appropriate containers by a static mixer. The final mixed solution was placed in a 37°C water bath and monitored until gelation was complete. An illustration of the formation of the organogel composition is as Figure 6 shown.

[0130]

[0131] *CHP is supplied @80%, the other 20% are aromatic solvents.

[0132] Additional organogels were pre...

Embodiment 2

[0161] Example 2: Characterization of organogels

[0162] The compression modulus of the prepared organogel was measured by a single column material testing system (Instron Model Number 3343) using ASTM Standard D575-91 Rubber Compression Standard Test Method, which is incorporated herein by reference.

[0163] Table 1 summarizes the gel setting time and compressive modulus of the prepared organogels.

[0164] Table 1

[0165]

Embodiment 3

[0166] Embodiment 3: stability test

[0167] The organogels prepared above were screened for shelf-life stability of the individual polymer system components (Cl and C2 solutions) under accelerated conditions at 60° C. for a comparable time corresponding to 18 months at room temperature. The results showed that the component solutions were stable and once combined formed organogels suitable for the intended application.

[0168] The organogel of Composition 1 was tested with an inner bag (Endologix) as a component of an endovascular aneurysm repair system surrounding a stent placed in an abdominal aortic aneurysm (AAA). The inner bag was prefilled and flushed with saline to remove air and determine the fill volume. After flushing, the two-component polymer system from Composition 1 was injected into the inner bag using a 2-barrel cartridge, dispensed using a ratchet gun at 180 mm Hg pressure. The inner pocket maintained its preset shape, thus illustrating the stability of th...

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Abstract

Various embodiments relate to compositions for use in endoluminal devices and to methods of using compositions in endoluminal devices. The compositions include two parts, a first part including a first solution and a second part including a second solution, wherein the first solution comprises one or more pre-polymers, a non-aqueous solvent, a polymerization co-initiator or initiator and optionally one or more chain extenders and additives, and the second solution comprises a polymerization initiator or co-initiator, a non-aqueous solvent and optionally one or more chain extenders and additives.

Description

[0001] Cross references to related patent applications [0002] This application claims priority to U.S. Provisional Application No. 62 / 575,827, filed October 23, 2017, the entire contents of which are incorporated herein by reference. technical field [0003] Embodiments disclosed herein generally relate to compositions for use in endoluminal devices and methods of using the compositions in endoluminal devices. Various embodiments relate to biostable organogels and methods for treating aneurysms. Background technique [0004] An aneurysm is an enlarged or raised section in a blood vessel that is often prone to rupture and therefore poses a serious risk to the patient. Aneurysms can occur in any vessel, but special attention is paid when they arise in cerebral vessels or a patient's aorta. [0005] Abdominal aortic aneurysms (AAA's) are classified based on their location within the aorta as well as their shape and complexity. Aneurysms found below the renal arteries are c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/02A61F2/06C08L33/00C08L33/08
CPCA61F2/06C08L33/08A61F2210/0061A61F2210/0085C08F220/286C08F222/103C08F122/1006C08F222/102A61B17/12113A61B17/12195A61F2/07A61L24/0031A61L24/06A61L2300/802A61L2430/36C08L2205/025
Inventor M·杜拉利L·琼斯
Owner ENDOLOGIX LLC