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Application of traditional Chinese medicine composition and preparation thereof in preparation of drug for treating ALI (acute lung injury)

A technology of acute lung injury and composition, applied in the field of traditional Chinese medicine, can solve problems such as adverse reactions and increased mortality in ARDS patients

Inactive Publication Date: 2020-06-26
ZHANGZHOU PIEN TZE HUANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a large number of studies have shown that early use of high-dose corticosteroids in patients with ARDS may increase mortality and cause adverse reactions, so comprehensive evaluation is required when using these drugs for acute lung injury

Method used

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  • Application of traditional Chinese medicine composition and preparation thereof in preparation of drug for treating ALI (acute lung injury)
  • Application of traditional Chinese medicine composition and preparation thereof in preparation of drug for treating ALI (acute lung injury)
  • Application of traditional Chinese medicine composition and preparation thereof in preparation of drug for treating ALI (acute lung injury)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] This embodiment provides a traditional Chinese medicine composition, the composition of which is as follows: 138.9g of Chonglou, 83.3g of Scutellaria baicalensis, 138.9g of Fritillaria japonicus, 277.8g of Commelina chinensis, 83.3g of Anemarrhena anemarrhena, 185.2g of gypsum, 83.3g of tangerine peel, Citrus aurantium 83.3g, cocklebur 138.9g, bitter almond 83.3g, bellflower 83.3g, patchouli 83.3g, perilla leaf 83.3g, roasted licorice 83.3g.

[0034] The preparation method of this pharmaceutical composition comprises:

[0035]Take the selected weight of Scutellaria baicalensis, add 10 times the weight of water to decoct for 1.5 hours, filter to obtain the first medicinal residue and the first filtrate, concentrate the first filtrate to 5 times the amount, and adjust the pH value to 1-2 at 80°C , placed for 24 hours, filtered, and the filter residue was crude baicalin, set aside;

[0036] Take selected weights of tangerine peel, citrus aurantii, bitter almond, patchouli...

Embodiment 2

[0040] This embodiment provides a traditional Chinese medicine composition, the raw material composition of which is: 160g of Chonglou, 100g of Scutellaria baicalensis, 160g of Fritillaria japonicus, 300g of Commelina chinensis, 60g of Anemarrhena anemarrhena, 150g of gypsum, 100g of tangerine peel, 100g of Fructus aurantii, Xanthium chinensis 150g, 60g bitter almonds, 60g bellflower, 60g patchouli, 60g perilla leaves, 60g roasted licorice.

[0041] The preparation method of this pharmaceutical composition comprises:

[0042] Take the selected weight of Scutellaria baicalensis, add 10 times the weight of water to decoct for 1.5 hours, filter to obtain the first medicinal residue and the first filtrate, concentrate the first filtrate to 5 times the amount, and adjust the pH value to 1-2 at 80°C , placed for 24 hours, filtered, and the filter residue was crude baicalin, set aside;

[0043] Take selected weights of tangerine peel, citrus aurantii, bitter almond, patchouli and pe...

Embodiment 3

[0047] This embodiment provides a traditional Chinese medicine composition, the raw materials of which are composed of: 100g of Chonglou, 60g of Scutellaria baicalensis, 100g of Fritillaria japonicus, 250g of Commelina chinensis, 100g of Anemarrhena anemarrhena, 200g of gypsum, 70g of tangerine peel, 60g of Fructus aurantii, and cocklebur 100g, 100g bitter almond, 100g bellflower, 100g patchouli, 100g perilla leaf, 100g roasted licorice.

[0048] The preparation method of this pharmaceutical composition comprises:

[0049] Take the selected weight of Scutellaria baicalensis, add 10 times the weight of water to decoct for 1.5 hours, filter to obtain the first medicinal residue and the first filtrate, concentrate the first filtrate to 5 times the amount, and adjust the pH value to 1-2 at 80°C , placed for 24 hours, filtered, and the filter residue was crude baicalin, set aside;

[0050] Take selected weights of tangerine peel, citrus aurantii, bitter almond, patchouli and peril...

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Abstract

The invention belongs to the field of traditional Chinese medicines and particularly relates to an application of traditional Chinese medicine composition and a preparation thereof in preparation of adrug for treating ALI (acute lung injury). The traditional Chinese medicine composition is prepared from raw materials such as rhizoma paridis, radix scutellariae, thunberg fritillary bulb, common dayflower herbs, rhizoma anemarrhenae, gypsum, dried tangerine or orange peel, fructus aurantii, fructus xanthii, bitter almond kernels, radix platycodonis, cablin potchouli herbs, folium perillae and prepared liquorice roots. Study results show that the traditional Chinese medicine composition can reduce the water content and the permeability index of the lung of a model rat with ALI and reduce thelevel of cell inflammatory factors, improve change of ALI lung histopathology, has a remarkable treatment effect on ALI and is suitable for clinical popularization and application.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to the application of a traditional Chinese medicine composition and its preparation in the preparation of medicines for treating acute lung injury. Background technique [0002] Acute lung injury (ALI) is caused by injury factors (such as sepsis, endotoxic shock, acute respiratory distress syndrome virus, aspiration pneumonia, contusion, pulmonary embolism, etc.) Endothelial cell damage results in diffuse pulmonary interstitial and alveolar edema, clinically manifested as respiratory distress, accompanied by symptoms such as intractable hypoxemia, decreased lung compliance, and diffuse inflammatory infiltration. In severe cases, it can directly transform into acute respiratory distress Acute respiratory distress syndrome (ARDS). Its incidence rate is as high as 79 / 100,000 per year, and the mortality rate is as high as 30% to 40%. At present, the clinical treatment met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61P11/00A61K33/06
CPCA61K33/06A61K36/28A61K36/346A61K36/484A61K36/532A61K36/535A61K36/539A61K36/736A61K36/752A61K36/88A61K36/896A61K36/8964A61K36/8966A61K2236/331A61K2236/39A61P11/00A61K2300/00
Inventor 罗志毅洪绯袁慧君于娟林丽敏
Owner ZHANGZHOU PIEN TZE HUANG PHARM
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