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Yimusake extract and production method and application thereof

A technology of extract and alcohol extract, which is applied in the field of Yimusak extract and its preparation, can solve the problems of large dosage and unclear active ingredients

Pending Publication Date: 2020-06-26
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This preparation process is too simple, and there are many ineffective components such as cellulose, polysaccharides, tannins, etc. mixed in, and there is a problem that the active ingredients are not clear
In addition, due to the large number of ineffective components in traditional tablets, the one-time consumption dose of this medicine is relatively large (about 1.5 grams).

Method used

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  • Yimusake extract and production method and application thereof
  • Yimusake extract and production method and application thereof
  • Yimusake extract and production method and application thereof

Examples

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preparation example Construction

[0032] The invention provides a preparation method of Yimusak extract, comprising the following steps:

[0033] (1) Mix cloves, oysters, poppy shells, nutmeg, frankincense, nux, galangal and saffron according to their prescription amounts in Imsac, and perform the first crushing and sieving to obtain the mixture powder ;

[0034] (2) Carrying out alcohol reflux extraction to the mixture powder to obtain alcohol extract extract and alcohol extract dregs;

[0035] (3) Carrying out the first concentration, the first freeze-drying and the second crushing and sieving of the alcohol extract extract in sequence to obtain the alcohol extract powder;

[0036] (4) boiling the alcohol extract dregs to obtain water extract extract and water extract dregs;

[0037] (5) Carrying out the second concentration, the second freeze-drying and the third crushing and sieving in sequence to the water extract extract to obtain the water extract powder;

[0038] (6) Mix the alcohol extract powder, ...

Embodiment 1

[0059] (1) According to the original formula dose of Yimusak, mix cloves, oyster, poppy shell, nutmeg, frankincense, nuxe seeds, galangal and saffron, grind and sieve to obtain a mixture with a particle size of 150-250 μm powder. The formula quantities of these eight kinds of medicinal materials are shown in Table 1.

[0060] (2) Carry out ethanol solution reflux extraction to the mixture powder, wherein, the volume fraction of ethanol solution is 60%, the mass ratio of mixture powder and ethanol solution is 1:9; After flowing for 2 hours, the extracts obtained after two alcohol reflux extractions were mixed to obtain the alcohol extract extract, and the remaining medicinal residues were combined into the alcohol extract medicinal residues.

[0061] (3) Concentrate the alcohol extract extract at 0.085MPa for 8h, freeze-dry at -40°C for 48h, and obtain alcohol extract powder with a particle size of 150-250μm after crushing and sieving. After weighing, the alcohol extract The ...

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Abstract

The invention provides a Yimusake extract and a production method and application thereof, and belongs to the technical field of purification of medicines. According to the Yimusake extract and the production method and application thereof, by conducting alcohol reflux extraction and boiling extraction on mixture powder produced from eight components, apart from ox penises, musk and ambergris, inYimusake, active components can be extracted, and impurity components in a medicine are reduced; and by mixing alcohol extract powder, water extract powder, ox penises, musk and ambergris, the efficacy of the obtained Yimusake extract is basically the same as that of Yimusake tablets, while the medicine dose is significantly reduced. Results show that the administration dosage of the Yimusake extract is reduced by 65.37% compared with that of the commercially-available Yimusake tablets; and from the view of the key index of the number of times of insertion of mice, a therapeutic effect of theYimusake extract accounts for 92.41% of that of the commercially-available Yimusake tablets, and it shows that the efficacy of the Yimusake extract is basically the same as that of the commercially-available Yimusake tablets.

Description

technical field [0001] The invention relates to the technical field of medicine purification, in particular to an extract of Yimusak and its preparation method and application. Background technique [0002] Yimusak is a kind of medicine for invigorating kidney and strengthening yang, benefiting essence and strengthening astringency. It is used for impotence, premature ejaculation, slippery sperm, enuresis and neurasthenia. Yimusak is composed of 11 medicinal materials (frankincense, bullwhip, galangal, nuxmina, musk, tarragon, clove, poppy shell, saffron, nutmeg, saffron and fenugreek), and its tablet Traditionally, in addition to boiling poppy shells, the other 10 medicinal materials are all crushed, sieved, mixed directly and pressed into tablets for use. This preparation process is too simple, and many ineffective components such as cellulose, polysaccharides, tannins, etc. are mixed in, and there is a problem that the active ingredients are not clear. In addition, beca...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61P13/00A61P15/00A61P15/10A61P25/20A61K35/38A61K35/48A61K35/55
CPCA61K35/38A61K35/48A61K35/55A61K36/185A61K36/324A61K36/56A61K36/61A61K36/66A61K36/88A61K36/898A61K36/9062A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P13/00A61P15/00A61P15/10A61P25/20A61K2300/00
Inventor 阿地力江·伊明阿卜杜热伊木·如则木合布力·阿布力孜毛吾兰·买买提依明
Owner XINJIANG MEDICAL UNIV