Material with biological adhesive and biodegradable component, and preparation method and application thereof

A polyurethane adhesive, amino technology, applied in the direction of surgical adhesives, applications, medical science, etc., to achieve strong offensive ability, improve shear strength and adhesive strength, and good effect

Inactive Publication Date: 2020-06-26
杭州鹿扬科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the research on bio-adhesives has a history of several decades, including many types, there is no adhesive that can meet all the above requirements. Therefore, it is important to develop bio-adhesives that are more suitable for clinical use The direction of efforts of researchers in the field

Method used

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  • Material with biological adhesive and biodegradable component, and preparation method and application thereof
  • Material with biological adhesive and biodegradable component, and preparation method and application thereof
  • Material with biological adhesive and biodegradable component, and preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0034] Provide a kind of preparation method of polyurethane adhesive, it is characterized in that, comprises the following steps:

[0035] S1. Drying of polyols: Take castor oil and polyethylene glycol, remove water under vacuum at 105-115°C for 2.5-3h, after the water removal is completed, let stand and cool down to 50-52°C;

[0036] S2. Synthesis of prepolymer: under the condition of nitrogen protection, after the dehydrated and dried polyol is heated to 70-72°C, add isophorone diisocyanate, and react for 6-7h under the condition of slow stirring;

[0037] Grafting of S3, 2-amino-4-sulfonic acid benzoic acid: add the isopropanol solution containing 2-amino-4-sulfonic acid benzoic acid and methyl propionate to the prepolymer obtained in step S2, 70 React at a constant temperature of -72°C for 1-2 hours, after the reaction is completed, cool down to room temperature, and store the product in isolation from water vapor for later use;

[0038]The castor oil: polyethylene glycol...

Embodiment 1

[0048] Provide a kind of preparation method of polyurethane adhesive, comprise the following steps:

[0049] S1. Drying of polyols: first add 0.6g castor oil and 7.3g polyethylene glycol to the container, remove water in vacuum at 110°C for 2.5h, after the water removal is completed, let stand and cool down to 50°C;

[0050] S2. Synthesis of prepolymer: under the condition of nitrogen protection, after the dehydrated and dried polyol is heated to 70°C, add 4.2g of isophorone diisocyanate, and react for 6 hours under the condition of slow stirring;

[0051] Grafting of S3, 2-amino-4-sulfonic acid benzoic acid: add isopropanol containing 4g 2-amino-4-sulfonic acid benzoic acid and 5.8mg methyl propionate to the prepolymer obtained in S2 step The solution was 30mL, and reacted at a constant temperature of 70°C for 1h. After the reaction was completed, the product was cooled to room temperature, and the product was isolated from water vapor and stored for later use.

Embodiment 2

[0053] Methyl propionate was not added, and the remainder was completely consistent with Example 1.

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Abstract

The invention provides a material with both a biological adhesive and a biodegradable component, and a preparation method and an application thereof, and belongs to the field of medical adhesives. Thepreparation method comprises the following steps: taking castor oil and polyethylene glycol, performing vacuum water removal for 2.5-3 h at 105-115 DEG C, standing and cooling to 50-52 DEG C after dewatering is finished, heating the dehydrated and dried polyhydric alcohol to 70-72 DEG C under a nitrogen protection condition, adding isophorone diisocyanate, carrying out a reaction for 6-7 h undera slow stirring condition, adding an isopropanol solution containing 2-amino-4-sulfobenzoic acid and methyl propionate into the obtained prepolymer, carrying out a constant temperature reaction for 1-2 h at 70-72 DEG C, cooling to a room temperature after the reaction is finished, and storing the product in a water vapor isolation manner for later use. The novel polyurethane adhesive obtained in the invention can be quickly cured, is high in bonding strength and tensile strength and low in swelling degree, and has good biodegradability and biocompatibility.

Description

technical field [0001] The invention belongs to the field of medical adhesives, and in particular relates to a material having both bioadhesive and biodegradable components, a preparation method and an application thereof. Background technique [0002] With the rapid progress of modern medicine, the clinical requirements for surgical effects are getting higher and higher. While minimizing the patient's pain and recovering as quickly as possible, it is also hoped to restore the appearance to the greatest extent. For many years, the traditional approach in trauma surgery has been with the help of mechanical connectors. Although the above-mentioned mechanical connectors are widely used, there are many deficiencies. Such as the use of suture thread itself will produce damage to the surrounding tissue, and it is not suitable for the complex operation process itself. When suturing is used in clinical treatment, complications due to leakage of body fluids are common, and serious...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/83C08G18/75C08G18/66C08G18/48C08G18/36A61L24/04A61L24/00
CPCA61L24/001A61L24/0042A61L24/046C08G18/36C08G18/4833C08G18/6696C08G18/755C08G18/833C08L75/08
Inventor 不公告发明人
Owner 杭州鹿扬科技有限公司
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