Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of compound and aromatic amide, which is applied in the field of preparation of aromatic amide compounds, can solve the problems of insufficient cost and unsuitability for large-scale production, and achieve the effects of low cost, low pollution and reduced pollution
Pending Publication Date: 2020-07-03
中国平煤神马控股集团有限公司 +1
View PDF12 Cites 3 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, it is not suitable for large-scale production due to the use of expensive phase transfer catal
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0033] In the reaction kettle, add 12.2g, 0.1mol benzoic acid, add 38.4g, 0.4mol ammonium carbonate, 0.8g, 10mmol zinc oxide, 1.25g, 5mmol tungstic acid, 200ml xylene, heat up to 160 degrees, and stir for 8 Hour. After suction filtration, the solvent was removed by rotary evaporation under reduced pressure to obtain 10.6 g of crude benzamide as a khaki product. The crude product was recrystallized by heating under reflux with 30 ml of ethanol to obtain 9.2 g of white crystals with a yield of 76.0%.
Embodiment 2
[0035] In the reaction kettle, add 12.2g, 0.1mol benzoic acid, add 24.0g, 0.4mol ammonium carbonate, 0.8g, 10mmol zinc oxide, 1.25g, 5mmol tungstic acid, 200ml xylene, heat up to 160 degrees, and stir for 8 Hour. After suction filtration, the solvent was removed by rotary evaporation under reduced pressure to obtain 11.6 g of a yellow crude product of benzamide. The crude product was recrystallized by heating under reflux with 30 ml of ethanol to obtain 9.8 g of white crystals with a yield of 80.9%.
Embodiment 3
[0037] In the reactor, add 15.6g, 0.1mol o-chlorobenzoic acid, add 38.4g, 0.4mol urea, 0.8g, 10mmol zinc oxide, 1.03g, 5mmol ruthenium chloride, 200ml NMP, heat up to 150 degrees, and stir the reaction 12 hours. After suction filtration, the solvent was removed by rotary evaporation under reduced pressure to obtain 15.9 g of a yellow crude product of o-chlorobenzamide. The crude product was recrystallized by heating under reflux with 30 ml of ethanol to obtain 13.3 g of white crystals with a yield of 85.8%.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The present invention provides a preparation method of an aromatic amide compound. In an organic solvent, under the effect of a catalyst, an aromatic acid compound and an amine source are subjected toa dehydration reaction to obtain the aromatic amide compound, wherein the aromatic acid compound is an aromatic acid, a substituted aromatic acid, a heterocyclic aromatic acid or a substituted heterocyclic aromatic acid; and the substituent group of amide is any substituent group of H, a C1-C8 straight-chain alkyl or branched-chain alkyl group, a benzene ring or an aromatic ring. The aromatic amide compound is an important chemical intermediate, and the synthesis method is mild in reaction condition and high in yield.
Description
technical field [0001] The invention relates to a preparation method of a chemical intermediate, in particular to a preparation method of aromatic amide compounds. Background technique [0002] Amide compounds are an important class of compounds, which have a wide range of applications in medicine, biology, and materials. Benzamides are often used as herbicides, fungicides, dispersants, antipsychotics and vasodilators. Therefore, the efficient and low-cost synthesis of amides is very meaningful. At present, the synthesis of amides generally uses toxic solvents, precious metals, and highly toxic chlorinated reagents, and the operation is complicated and needs to be carried out under anhydrous conditions, and the post-treatment is cumbersome. It is not suitable for large-scale application. Aromatic amide is an important chemical intermediate and an important intermediate of various chemical products. There are many methods for synthesizing this type of compound, as shown in...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more