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Method and special device for measuring crymodynia behavior differences of different mice

A special device and mouse technology, applied in applications, other equipment, medical formulas, etc., can solve the problems of mouse injury, single function, simple structure, etc., and achieve the effect of increasing types and improving test accuracy

Active Publication Date: 2020-07-24
JINHUA VOCATIONAL TECH COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The acetone low temperature test is highly subjective, and human factors have a greater influence. Therefore, the more objective cold plate test is more widely used; and the tail wagging test is usually performed by researchers pressing the back of the mouse and letting its tail hang down in ice water. The existing mouse cold pain test device usually only has the function of one of the tests, the structure is simple, and the function is single. Among them, the tail wagging test is manually pressed by the mouse, which is easily injured by the mouse and affects test conducted

Method used

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  • Method and special device for measuring crymodynia behavior differences of different mice
  • Method and special device for measuring crymodynia behavior differences of different mice
  • Method and special device for measuring crymodynia behavior differences of different mice

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Experimental program
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Embodiment 1

[0035] Please refer to the attached Figure 1~4 , the present invention provides a technical solution:

[0036] A method for measuring differences in cold pain behavior of different mice, comprising the following steps:

[0037] S1, get two groups of 6-week-old mice, 10 in each group, the first group is used for cold plate test, wherein two mice are not treated, as control group 1 and control group 2, the remaining 8 mice After intraperitoneal injection of anesthesia, it was fixed on the processing table, and the nerves of its right hind limb were ligated; the second group was used for the tail wagging test, in which two mice were injected with normal saline of equal weight as control group 1 and control group 2, and the rest 8 mice were anesthetized by intraperitoneal injection, fixed on the processing table, and ligated their tail nerves;

[0038] S2, the control group one of the cold plate test group is placed on the first container 7 on the fixed plate 2, and the other 9...

Embodiment 2

[0046] The method of this embodiment is basically the same as that of Example 1, the difference is that in S1, the hindlimbs and tails of the mice treated with nerve ligation in the two groups of mice were injected with equal weight and different gradient concentrations of analgesic drugs, and the control group 1 and The mice in control group 2 were injected with the same weight of normal saline, repeating S2-S4; used to test the analgesic effect of different concentrations of analgesic drugs.

Embodiment 3

[0048] The structure of this embodiment is basically the same as that of Embodiment 1, the difference is that, as Figure 5 and Figure 6 As shown, the moving block 6 and the fixed plate 2 are fixed with a limit plate 601 corresponding to the two sides of each cylinder 9, and the limit plate 601 is provided with a chute 602, and the two sides of the cylinder 9 are symmetrically fixed with sliders. 905, the sliding block 905 is slidably connected to the slide grooves 602 on both sides, so that the cylinder body 9 can be installed on the moving block 6 and the fixed plate 2 correspondingly, and can be easily removed after the test is finished.

[0049] In the chute 602, a block 603 is slidably connected, and a spring is provided between the inner end surface of the block 603 and the inner surface of the chute 602, so that after the slide blocks 905 on both sides of the cylindrical body 9 slide into the chute 602, two The spring on the side and the clamping block 603 clamp the c...

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Abstract

The invention relates to the technical field of crymodynia tests and discloses a method and special device for measuring crymodynia behavior differences of different mice. The special device comprisesa water tank; the water tank is internally provided with a fixed plate and a thermometer; the fixed plate is provided with an electronic stopwatch and a moving assembly; and two sides of the fixed plate are provided with a first container and a second container. The two sides of the fixed plate are provided with the first container and the second container, so that a cold plate test and a fishtailing test can be simultaneously carried out; a moving block, a screw rod and other structures are arranged, so that the first container and the second container are convenient to move, and a glass plate and the tail parts of the mice are immersed in ice water for a crymodynia test; a control group I and a control group II are arranged for normal-temperature non-nerve-ligation treatment control andcold sense non-nerve-ligation control, so that the types of the control groups are added and the test precision is improved; and multiple test groups injected with different concentrations of analgesic drugs are arranged for testing the analgesic effects of the different concentrations of drugs.

Description

technical field [0001] The invention relates to the technical field of cold pain test, in particular to a method for measuring the difference in cold pain behavior of different mice and a special device thereof. Background technique [0002] Neuropathic pain is pain caused by lesions or dysfunctions in the peripheral or central nervous system; neuropathic pain has a wide range of causes, complex pathological mechanisms, and diverse symptoms. The pathophysiological characteristics are mainly manifested as hyperresponsiveness of pain sensation, such as hyperalgesia, hyperalgesia and spontaneous pain. Diabetes, cancer, autoimmune disease, constant stress, toxic chemicals, alcoholism, and the use of certain drugs can all contribute to the occurrence of these disorders. The currently proposed pathogenesis involves both peripheral and central neural pathways. [0003] Neuropathic pain is relatively common, with an incidence rate of about 1% in the population; it is a chronic pai...

Claims

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Application Information

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IPC IPC(8): A01K29/00A61K49/00A61D3/00
CPCA01K29/005A61K49/0008A61D3/00
Inventor 吴玲玲陈浩浩徐庆丁明星
Owner JINHUA VOCATIONAL TECH COLLEGE
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