Composition for cancer radiotherapy sensitization and application thereof

A composition and cancer technology, applied in the field of tumor, can solve the problems of no research results and insufficient excavation, and achieve the effect of effective treatment strategy, major clinical and socio-economic significance
CN111437389AInactive Publication Date: 2020-07-24SUN YAT SEN UNIV CANCER CENT
1 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SUN YAT SEN UNIV CANCER CENT
Publication Date
2020-07-24
Estimated Expiration
Not applicable Β· inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a composition for cancer radiotherapy sensitization and application thereof. The composition comprises one or more proteasome inhibitors. Researches show that the proteasome inhibitors, especially 20S CP inhibitors, can block DSB, have a significant synergistic effect on tumor radiotherapy, and effectively solve the problems of low radiotherapy sensitivity, not significant curative effect and large side effect in existing clinical treatment. The clinical use of the proteasome inhibitors can significantly improve the radiotherapy sensitivity of tumor patients, thereby greatly improving the therapeutic effect of the tumor patients.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of tumors, and in particular relates to a composition for cancer radiosensitization and its application. Background technique

[0002] Chemoradiotherapy, which accounts for a large proportion of current cancer treatment modalities, significantly increases the control rate of local progression and leads to clinical and histological tumor regression. However, because the treatment is limited by indications, contraindications, drug resistance and high-dose side effects, the curative effect is not ideal. Therefore, it has become a current research hotspot to study new therapeutic strategies combined with radiotherapy and chemotherapy to improve the sensitivity of cancer patients. At the same time, it is necessary and urgent to study the mechanism of their combined effects. For example, in the treatment of colorectal cancer, radiotherapy is one of the important methods in the comprehensive treatment of colorectal cancer, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More