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A complex and composition technology, applied in the field of preparing the composition of the present invention, can solve the problems of expensive manufacture and packaging of biphasic compositions, difficulty in preparing low-moisture oral care compositions, etc.

Active Publication Date: 2020-07-24
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Low moisture oral care compositions can be difficult to formulate to have the desired rheological properties, and biphasic compositions are significantly more expensive to manufacture and package

Method used

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Embodiment 1

[0117] Embodiment 1: the synthesis of stannous ascorbyl phosphate and tin ascorbyl phosphate

[0118] Stannous ascorbyl phosphate sample preparation: Dissolve 3.220g sodium ascorbyl phosphate in 100mL water, then add 1.567g SnF 2 . The mixture was stirred until complete dissolution and heated at 60 °C for one hour. The solution was directly analyzed by 13C-NMR and diluted to 5000ppm, then analyzed by LC-MS

[0119] Table 1. Materials details for the synthesis of stannous ascorbyl phosphate

[0120]

[0121] Preparation of tin ascorbyl phosphate sample: 0.644g SnF 2 Dissolve sodium ascorbyl phosphate in 100 mL of water, then add 1.567 g of SnF 4 . The mixture was stirred until complete dissolution and heated at 60 °C for one hour. The solution was directly analyzed by 13C-NMR and diluted to 5000 ppm, then analyzed by LC-MS.

[0122] Table 2. Material details for the synthesis of tin ascorbyl phosphate

[0123]

[0124]

Embodiment 2

[0125] Embodiment 2: LC-MS analysis

[0126] Briefly, LC- MS analysis. The capillary LC system is equipped with a capillary binary pump (model G1376A), a DAD detector (G1315C), a micro vacuum degasser (model G4225A), and a column oven (model G1316A). The capillary pump was set in microfluidic mode. LC separation was achieved using an Agilent Zorbax SB-Aq column (Agilent Technologies, Palo Alto, CA, USA, part number 871700-914) with 2.1 mm inner diameter x 50 mm dimensions and a 3.5 μm particle size. The mobile phase was methanol:water / 5:95. The flow rate was 70 μL / min, and the injection volume was 1 μL. The AB Sciex tandem mass spectrometer was operated in negative ion mode under the following conditions: Nitrogen (>99.99%) for curtain gas at 10 psi, ion source gases 1 and 2 at 10 psi and 10 psi, respectively. The ESIIonSpray voltage was set to 5.5kV in the ESI interface. The declustering and entry potentials were set to 80V and 5.5V, respectively. The temperature of th...

Embodiment 3

[0127] Embodiment 3: NMR experiment

[0128] Performed on a Bruker Avance spectrometer (Bruker-Biospin, Billerica, MA, US) with a 5mm CryoProdigy platform 13 C NMR studies, 1 The operating frequency of H is 500.0MHz, 13 C operates at 125.7 MHz in water at 25 °C. use 1 The H decoupling sequence ("zgig" from the Bruker pulse library) acquires all 13 C NMR spectrum.

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Abstract

Disclosed herein are stannous-ascorbyl phosphate and stannic-asorbyl phosphate complexes, oral care compositions stannous-ascorbyl phosphate and stannic-asorbyl phosphate complexes, and methods of making and using the same.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to and benefit of U.S. Provisional Application No. 62 / 599,077, filed December 15, 2017, the contents of which are incorporated herein by reference in their entirety. Background technique [0003] Oral care compositions containing a source of stannous ions exhibit excellent clinical benefits, particularly in reducing gingivitis and treating or preventing erosive tooth demineralization. Stannous fluoride is well known in clinical dentistry for its over forty-year history of therapeutic benefits. However, until recently, its popularity was limited due to instability in aqueous solutions. This limits the range of formulations that can be incorporated into stannous compounds, for example. The instability of stannous fluoride in water is mainly due to stannous ions (Sn 2+ ) reactivity. Stannous salts are readily hydrolyzed above pH 4, leading to precipitation from solution with consequent l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/655A61Q11/00A61K8/19
CPCA61K8/676A61K8/19A61K2800/58A61Q11/00C07F9/65515A61K8/21A61K8/27A61K8/365A61K8/44A61K8/55
Inventor 郝志刚程池原潘龙R·苏布拉曼亚姆
Owner COLGATE PALMOLIVE CO
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