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Application of TPBC-PEG-TP combined photodynamic therapy in treatment of osteosarcoma

A photodynamic and osteosarcoma technology, applied in the field of biomedicine, can solve problems such as large side effects

Inactive Publication Date: 2020-07-31
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

[0006] Triptolide, also known as triptolide, is an epoxy diterpene lactone compound extracted from Tripterygium wilfordii, the main active ingredient of Tripterygium wilfordii extract, with broad-spectrum, high-efficiency Anti-tumor effect, but its clinical use is limited due to its large side effects

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  • Application of TPBC-PEG-TP combined photodynamic therapy in treatment of osteosarcoma
  • Application of TPBC-PEG-TP combined photodynamic therapy in treatment of osteosarcoma
  • Application of TPBC-PEG-TP combined photodynamic therapy in treatment of osteosarcoma

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Embodiment Construction

[0024] The present invention will be further elaborated below in conjunction with the accompanying drawings and specific embodiments. These examples should be understood as only for illustrating the present invention but not for limiting the protection scope of the present invention. After reading the contents of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent changes and modifications also fall within the scope defined by the claims of the present invention.

[0025] ① The absorption range of TPBC detected by ultraviolet light is extended to the near-infrared region. With the increase of the number of wavelengths, its tissue penetration to tumors is enhanced, which is conducive to improving the therapeutic effect; the absorption peak intensity at 740nm is strong, and after connecting with peg Does not affect absorption peaks (eg figure 1 shown).

[0026] ② Through ultraviolet detection ...

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Abstract

The invention discloses application of TPBC-PEG-TP combined photodynamic therapy in treatment of osteosarcoma. The invention discloses application of a pH response nano-carrier, namely a double-reduction monohydroxy tetraphenyl porphyrin (TPBC)-polyethylene glycol nano-micelle (ethylene glycol methoxy poly, PEG) carrier-coated triptolide (TP) (TPBC-PEG-TP) combined photodynamic therapy in preparation of medicines for treating growth and metastasis of osteosarcoma. The invention provides a novel tumor-targeting delivery system combined with the photodynamic therapy, and the system can be used for preventing and treating osteosarcoma occurrence, development, metastasis and drug resistance, and can effectively solve the problems of high osteosarcoma death rate and short survival time.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a double-reduced monohydroxytetraphenylporphyrin (TPBC)-polyethylene glycol nanomicelle (ethylene glycol methoxy poly, PEG) coated triptolide (TP) with a Ph-responsive nano-carrier Application of (TPBC-PEG-TP) combined with photodynamic therapy in the treatment of growth and metastasis of osteosarcoma. Background technique [0002] Osteosarcoma (OS) is the most common primary malignant bone tumor. There are two peaks of incidence, which are children / adolescents aged 10-14 and the elderly over 65 years old. Children / adolescents frequently occur . The main clinical symptoms of osteosarcoma are pain, mass, and limb movement impairment. The clinical and pathological changes are bone destruction, which is characterized by osteolysis. The course of the disease is characterized by high malignancy, high heterogeneity, rapid growth, and early metastasis. . [0003] Osteosarcoma i...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/10A61K47/22A61K41/00A61K31/585A61P35/00
CPCA61K9/1075A61K31/585A61K41/0057A61K47/10A61K47/22A61P35/00
Inventor 杨燕萍张伟安王拥军王雯艺胡少朴常君丽支文兰王晓波梁倩倩刘书芬
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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