Modified nickel-cobalt Prussian blue analogue nano material and application thereof, and targeted drug
A Prussian blue and nanomaterial technology, applied in the field of biomedical materials, can solve the problems of poor controlled release performance and low drug loading efficiency, and achieve the effects of good biocompatibility, high drug loading efficiency, and high drug loading rate.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Example Embodiment
[0059] Example 1
[0060] The modified nickel cobalt Prussian blue analog nano material of this embodiment is NiCo-PBA@PEGMA, which includes NiCo-PBA and a polymer coated on the surface of NiCo-PBA by PEGMA polymerization.
[0061] The polymerization process specifically includes the following steps:
[0062] (1) Anchoring of initiator: ultrasonically disperse 50 mg NiCo-PBA in a flask containing 4.0 mL DMF, then place the flask in ice water; then add 3.8 mL triethylamine (TEA) and 3.8 in sequence under stirring conditions mL 2-bromoisobutyryl bromide (BiBB); after the addition is complete, continue to stir overnight; then filter to obtain a solid; use CH 2 Cl 2 Wash the solid until the washing liquid is clear, and then dry the solid at 50°C to obtain NiCo-PBA (labeled NiCo-PBA-Br) after anchoring the initiator;
[0063] (2) ATRP synthesis: Mix 20mg NiCo-PBA-Br, 1g PEGMA and 26μL PMDETA in 3mL toluene evenly to obtain a mixed solution; before the reaction, bubbling nitrogen into the m...
Example Embodiment
[0064] Example 2
[0065] The modified nickel cobalt Prussian blue analog nano material of this embodiment is NiCo-PBA@Tb 3+ @PEGMA, including NiCo-PBA and polymers coated on the surface of NiCo-PBA by PEGMA polymerization.
[0066] Among them, NiCo-PBA is doped with Tb 3+ , The doping method is: 50mg NiCo-PBA and 15mg TbCl 3 ·6H 2 O was mixed uniformly in ethanol, and then magnetically stirred at 70°C in an oil bath for 30 minutes, and then filtered to obtain the product. Then the obtained product was washed with ethanol and dried to obtain the final product (NiCo-PBA@Tb 3+ ).
[0067] The specific polymerization process of PEGMA is basically the same as in Example 1, except that: NiCo-PBA is replaced with NiCo-PBA@Tb 3+ .
[0068] Two, application examples
Example Embodiment
[0069] Example 3
[0070] In this example, the NiCo-PBA@PEGMA in Example 1 was used as the carrier, and the drug DOX was loaded to obtain the NiCo-PBA@PEGMA@DOX drug system. The specific preparation process was as follows: Add 3.0mL3mg / to 3mg NiCo-PBA@PEGMA powder mL of DOX aqueous solution to obtain the mixed solution, then place the mixed solution on a shaker at a temperature of 37°C and rotate at 180 rpm for 12 hours, then centrifuge, and wash the obtained solid to remove the unloaded DOX to obtain NiCo-PBA @PEGMA@DOX.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap