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Modified nickel-cobalt Prussian blue analogue nano material and application thereof, and targeted drug

A Prussian blue and nanomaterial technology, applied in the field of biomedical materials, can solve the problems of poor controlled release performance and low drug loading efficiency, and achieve the effects of good biocompatibility, high drug loading efficiency, and high drug loading rate.

Active Publication Date: 2020-08-11
ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing drug carriers generally have the problems of low drug loading efficiency and poor controlled release performance

Method used

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  • Modified nickel-cobalt Prussian blue analogue nano material and application thereof, and targeted drug
  • Modified nickel-cobalt Prussian blue analogue nano material and application thereof, and targeted drug
  • Modified nickel-cobalt Prussian blue analogue nano material and application thereof, and targeted drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] The modified nickel-cobalt Prussian blue analogue nanomaterial in this embodiment is NiCo-PBA@PEGMA, including NiCo-PBA and a polymer polymerized by PEGMA coated on the surface of NiCo-PBA.

[0061] The polymerization process specifically includes the following steps:

[0062] (1) Anchoring of the initiator: ultrasonically disperse 50 mg of NiCo-PBA in a flask containing 4.0 mL of DMF, then place the flask in ice water; then add 3.8 mL of triethylamine (TEA) and 3.8 mL 2-bromoisobutyryl bromide (BiBB); after the addition is complete, continue to stir overnight; then filter to obtain a solid; 2 Cl 2 Wash the solid until the washing solution is clear, and then dry the solid at 50°C to obtain NiCo-PBA (marked as NiCo-PBA-Br) after anchoring the initiator;

[0063] (2) ATRP synthesis: Mix 20mg NiCo-PBA-Br, 1g PEGMA and 26μL PMDETA in 3mL toluene to obtain a mixed solution; before the reaction, blow nitrogen into the mixed solution in the form of bubbling for 20min to purg...

Embodiment 2

[0065] The modified nickel-cobalt Prussian blue analogue nanomaterial in this embodiment is NiCo-PBA@Tb 3+ @PEGMA, including NiCo-PBA and polymers coated with PEGMA on the surface of NiCo-PBA.

[0066] Wherein NiCo-PBA is doped with Tb 3+ , the doping method is: mix 50mg NiCo-PBA with 15mg TbCl 3 ·6H 2 O was mixed evenly in ethanol, then magnetically stirred in an oil bath at 70°C for 30 min, and then filtered to obtain the product, which was then washed with ethanol and dried to obtain the final product (NiCo-PBA@Tb 3+ ).

[0067] The specific polymerization process of PEGMA is basically the same as in Example 1, the only difference is that NiCo-PBA is replaced by NiCo-PBA@Tb 3+ .

[0068] 2. Application examples

Embodiment 3

[0070] In this example, the NiCo-PBA@PEGMA in Example 1 was used as the carrier, and the drug DOX was loaded to obtain the NiCo-PBA@PEGMA@DOX drug system. The specific preparation process was: add 3.0mL3mg / mL of DOX aqueous solution to obtain a mixed solution, then place the mixed solution on a shaker at a temperature of 37 °C at a speed of 180 rpm for 12 h, then centrifuge, and wash the resulting solid to remove unloaded DOX, to obtain NiCo-PBA @PEGMA @DOX.

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Abstract

The invention belongs to the technical field of biomedical materials, particularly relates to a modified nickel-cobalt Prussian blue analogue nano material and an application thereof, and further relates to a targeted drug. The modified nickel-cobalt Prussian blue analogue nano material comprises a nickel-cobalt Prussian blue analogue nano cube and a polymer which is coated on the surface of the nickel-cobalt Prussian blue analogue nano cube and has pH responsiveness, wherein the polymer is formed by polymerizing polyethylene glycol methacrylate. The modification is realized by modifying THE polymer with pH responsiveness on the surface of THE nickel-cobalt Prussian blue analogue nano cube. When the modified nickel-cobalt Prussian blue analogue nano material is used as a drug carrier, themodified nickel-cobalt Prussian blue analogue nano material has relatively high drug loading efficiency and has pH response capability, so that controlled release of a drug can be realized.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a modified nickel-cobalt Prussian blue analog nanomaterial and its application, and also relates to a targeted drug. Background technique [0002] Although traditional cancer treatment methods such as chemotherapy and radiotherapy can kill cancer cells to a certain extent, they can also damage normal cells at the same time, so intracellular drug delivery systems (DDSs) were proposed. Intracellular drug delivery system achieves the purpose of treating cancer by transporting anticancer drugs into cancer cells, and can reduce the dose of anticancer drugs and minimize the side effects of drugs. The intracellular drug delivery system is mainly realized by targeted drugs, and the selection of drug carriers in targeted drugs is particularly important. [0003] At present, with the rapid development of nanobiotechnology, nanomaterials have gradually demonstrated...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/02A61K47/14A61K47/26A61K45/00A61P35/00
CPCA61K9/5115A61K9/5146A61K9/5123A61K45/00A61P35/00
Inventor 贾巧娟张治红何领好王明花李真真宋英攀崔静
Owner ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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