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Traditional Chinese medicine compound preparation for inhibiting Escherichia coli and biofilm thereof and application thereof

A technology of Escherichia coli and compound preparations, which is applied in the direction of antibacterial drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of strong drug resistance, recurrent attacks, long-term chronic infections, etc., and achieve small side effects , significant effect

Inactive Publication Date: 2020-08-18
GUIYANG XINTIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have found that about 85% of the clinical strains isolated from patients have the ability to form biofilms. This bacterial biofilm can adhere to the surface of epithelial cells and secrete extracellular matrix to wrap itself and form a special structure with group effects. , the bacterial population structure is extremely resistant to antibiotics, and it is difficult to completely eliminate antibiotics, resulting in chronic infections that cannot be cured for a long time and recur

Method used

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  • Traditional Chinese medicine compound preparation for inhibiting Escherichia coli and biofilm thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Preparation of Extract 1

[0021] Take 200g of Sijihong, 30g of hibiscus leaves, 200g of Dafengteng, 150g of three needles, 150g of Agrimony, 150g of Rhizoma Imperatae, 120g of Forsythia, add 7 times the amount of water to soak for 0.5 hours, decoct for 2 hours, filter, add medicine dregs Decoct 5 times the amount of water for 1.5 hours, filter, add 4 times the amount of water to decoct the medicinal residues for 1.5 hours; filter, discard the medicinal residues, combine the filtrate, concentrate and evaporate the filtrate under reduced pressure to form an extract, add 1.2 times Measure 80% ethanol, stir well, let stand for 24 hours, take the supernatant, filter the supernatant, recover the ethanol from the filtrate and concentrate it into an extract with a relative density of 1.10-1.20.

Embodiment 2

[0022] Example 2 Preparation of Extract 2

[0023] Take 350g of Sijihong, 10g of Hibiscus leaves, 150g of Dafengteng, 120g of Three Needles, 120g of Agrimony, 100g of Rhizoma Imperatae, 150g of Forsythia, the preparation method is the same as in Example 1, and the extract is obtained.

Embodiment 3

[0024] Example 3 Preparation of sugar-free granules

[0025] Take the extract 1 obtained in Example 1, take 70% of the extract and spray dry it to make a mist powder for later use, and make the remaining extract, spray powder, appropriate amount of stevioside and dextrin into granules, dry to make sugar-free granules Sub-package (6g / bag), that is to say.

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PUM

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Abstract

The invention provides a traditional Chinese medicine compound preparation for inhibiting Escherichia coli and a biofilm thereof and application thereof. The traditional Chinese medicine compound preparation provided by the invention is an oral preparation consisting of active ingredients including capitate knotweed herb, cotton rose hibiscus leaves, kadsura pepper stem, root of chinese barberry,hairyvein agrimony, lalang grass rhizome and fructus forsythiae and pharmaceutic adjuvants. The traditional Chinese medicine compound preparation has the effects of clearing away heat and toxic materials, promoting diuresis and treating stranguria, and promoting blood circulation to remove blood stasis, and has a remarkable inhibition effect on Escherichia coli and a biofilm thereof under the concentration of 5mg / mL. By inhibiting a bacterial biofilm formed by Escherichia coli, the traditional Chinese medicine compound preparation can effectively solve the problem that related diseases causedby Escherichia coli cannot be cured for a long time and attack repeatedly, and the curative effect is very remarkable.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation, in particular to a traditional Chinese medicine compound preparation for inhibiting Escherichia coli and its biofilm and its application. Background technique [0002] Under certain conditions, Escherichia coli can cause acute or chronic bacterial infection of the gastrointestinal tract in humans and various animals, often leading to acute or chronic diarrhea, hemorrhagic enteritis, peritonitis, appendicitis, cholecystitis, and even sepsis. chronic disease. [0003] At present, related diseases caused by Escherichia coli are often treated with oral antibiotics. However, studies have found that about 85% of the clinical strains isolated from patients have the ability to form biofilms. This bacterial biofilm can adhere to the surface of epithelial cells and secrete extracellular matrix to wrap itself and form a special structure with group effects. , the bacterial population ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P1/00A61P31/04
CPCA61K36/185A61K36/29A61K36/634A61K36/704A61K36/73A61K36/87A61K36/899A61K2236/331A61K2236/39A61P1/00A61P31/04A61K2300/00Y02A50/30
Inventor 陈中国
Owner GUIYANG XINTIAN PHARMA CO LTD
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