Human brain magnetic susceptibility tensor imaging method based on cross mode

Abstract

The invention discloses a human brain magnetic susceptibility tensor imaging method based on a cross mode, which can obtain phase data in multiple directions by rotating head postures when magnetic resonance imaging of a GRE sequence is carried out, so that the magnetic susceptibility and anisotropy information, namely magnetic susceptibility tensor imaging, of tissues can be deduced. In clinicalapplication, the scanning time and the imaging space limit the direction number and the direction angle of human brain imaging, so that the anti-interference capability of magnetic susceptibility tensor imaging is poor, which is an inverse problem of serious ill-conditioned conditions. According to the invention, a tensor spectrum decomposition technology is utilized; high-resolution magnetic susceptibility imaging and low-resolution diffusion imaging are combined; the invention provides a magnetic susceptibility tensor imaging method based on a cross mode. Phase data collected in six different head directions are used. Accurate calculation of the magnetic susceptibility tensor and the derivation amount is achieved, the method can be used for brain tissue microstructure characteristic evaluation, the derived fiber directional diagram is beneficial for exploring a novel living body nondestructive testing method of internal fiber characteristics of brain white matter and gray matter, andthe method has important significance in brain scientific research and brain disease diagnosis.

Description

technical field [0001] The invention relates to the technical field of medical image processing and analysis, in particular to a cross-mode-based human brain magnetic susceptibility tensor imaging method. Background technique [0002] Magnetic susceptibility is an inherent property of matter, which can reflect the degree of magnetization of biological tissues under the action of an external magnetic field. The stronger the magnetic sensitivity of a material, the greater the magnetic susceptibility. As a magnetic resonance imaging method, magnetic susceptibility imaging uses the phase information of gradient echo data to obtain the change characteristics of the local magnetic field after preprocessing; it can effectively quantify the iron content, calcification, blood oxygen saturation, etc. of the tissue. It is of great significance to the research and diagnosis of brain neurodegenerative diseases such as cerebral hemorrhage, multiple sclerosis and Parkinson's syndrome. The...

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Problems solved by technology

Further studies proposed to limit the magnetic susceptibility anisotropy to the white matter region and add a regularization term to the average magnetic susceptibility to strengthen the distinction between isotropic and anisotropic tissues, but this may result in the cutting of fiber pathways

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