A kind of antioxidant peptide derived from hickory chick and its preparation method and application

An anti-oxidative peptide, morel technology, applied in the preparation method of peptide, chemical instruments and methods, application, etc., can solve the problem of lack of neuroprotective agents, and achieve the effect of slowing down the damage of oxidative stress on the nervous system
CN111560052BActive Publication Date: 2021-04-20SAAS BIOTECH & NUCLEAR TECH RES INST
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
SAAS BIOTECH & NUCLEAR TECH RES INST
Publication Date
2021-04-20

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Abstract

The invention belongs to the field of biological small molecule active peptides, and relates to an antioxidant peptide derived from morel fruit body protein, specifically an antioxidant peptide derived from morel and its preparation method and application. The antioxidant peptide comprises the following sequence: Ala-Tyr-Asp-Gln-Ile-Asp-Ala-Ala-Pro-Glu-Glu-Lys. The antioxidant peptide consists of 12 amino acids with a relative molecular mass of 1348Da. The invention isolates the natural anti-oxidation polypeptide from the morel fruit body, verifies and explains the mechanism of the polypeptide for preventing and treating ischemic-hypoxic brain injury. The obtained active polypeptide is an excellent neuroprotective agent, has the function of slowing down the damage of the nervous system caused by oxidative stress, and can be used in the preparation of anti-ischemic-hypoxic brain injury medicines or health care products.
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Description

technical field

[0001] The invention belongs to the field of biological small molecule active peptides, and relates to an antioxidant peptide derived from morel fruit body protein, specifically an antioxidant peptide derived from morel and its preparation method and application. Background technique

[0002] Hypoxic-ischemic brain damage (Hypoxic-ischemic brain damage, HIBD) is one of the most common central nervous system diseases in newborns. It is mainly caused by the reduction or suspension of cerebral blood flow and oxygen after perinatal asphyxia. Injury or chronic long-term learning motor mental dysfunction has the characteristics of "three highs": high fatality rate, high morbidity rate, and high disability rate. Therefore, it is an urgent research topic to explore the pathogenesis of neonatal hypoxic ischemic encephalopathy and find safe and efficient prevention measures. Current studies confirm that apoptosis, as the final change in neurons among many influencing ...

Claims

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