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A kind of anti-glycation composition and its preparation method and application

A composition and anti-glycation technology, applied in cosmetic preparations, cosmetics, pharmaceutical formulations, etc., can solve the problems of prolonged skin renewal cycle and decreased skin metabolism function, achieve good anti-glycation effect, prolong shelf life, and improve safety Effect

Active Publication Date: 2021-02-26
泉后(广州)生物科技研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, it will also lead to the prolongation of the skin renewal cycle and the decline of the metabolic function of skin regeneration.

Method used

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  • A kind of anti-glycation composition and its preparation method and application
  • A kind of anti-glycation composition and its preparation method and application
  • A kind of anti-glycation composition and its preparation method and application

Examples

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Comparison scheme
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Embodiment approach

[0030] This example is an embodiment of the anti-glycation composition of the present invention. The anti-glycation composition in this example is a nanoemulsion, including the following components in parts by weight: 38 parts of Aurantia clematis extract, 36 parts of Ginkgo biloba extract, Hydroxytyrosol 6 parts, panthenol 20 parts, lecithin 3 parts, caprylic / capric triglyceride 15 parts. The preparation method of the anti-glycation composition of the present embodiment comprises the following steps:

[0031] (1) Mix the extract of Auranthus clematis, Ginkgo biloba extract, hydroxytyrosol and panthenol evenly to obtain a mixed solution;

[0032] (2) Add lecithin to the mixture obtained in step (1), mix well, add caprylic acid / capric triglyceride, disperse at 8000r / min for 5min to obtain colostrum, and then homogenize the colostrum under high pressure Treat to obtain nanoemulsion, wherein the high-pressure homogeneous conditions are pressure 700bar / min, temperature 35-45°C, a...

Embodiment 2

[0037] This example is an embodiment of the anti-glycation composition of the present invention. The anti-glycation composition in this example is a nanoemulsion, including the following components in parts by weight: 60 parts of Aurantia clematis extract, 60 parts of Ginkgo biloba extract, Hydroxytyrosol 10 parts, panthenol 30 parts, lecithin 5 parts, caprylic / capric triglyceride 20 parts. The preparation method of the anti-glycation composition of the present embodiment comprises the following steps:

[0038] (1) Mix the extract of Auranthus clematis, Ginkgo biloba extract, hydroxytyrosol and panthenol evenly to obtain a mixed solution;

[0039] (2) Add lecithin to the mixture obtained in step (1), mix well, add caprylic acid / capric triglyceride, first disperse at 12000r / min for 6min to obtain colostrum, and then homogenize the colostrum under high pressure Process to obtain nanoemulsions, wherein the high-pressure homogenization conditions are pressure 1200bar / min, tempera...

Embodiment 3

[0044] This example is an embodiment of the anti-glycation composition of the present invention. The anti-glycation composition in this example is a nanoemulsion, including the following components in parts by weight: 1 part of Aurantia clematis extract, 1 part of Ginkgo biloba extract, 1 part hydroxytyrosol, 0.1 part panthenol, 0.1 part lecithin, 5 parts caprylic / capric triglyceride. The preparation method of the anti-glycation composition of the present embodiment comprises the following steps:

[0045] (1) Mix the extract of Auranthus clematis, Ginkgo biloba extract, hydroxytyrosol and panthenol evenly to obtain a mixed solution;

[0046] (2) Add lecithin to the mixture obtained in step (1), mix well, add caprylic acid / capric triglyceride, first disperse at 5000r / min for 3min to obtain colostrum, and then homogenize the colostrum under high pressure Treat to obtain nanoemulsion, wherein the high-pressure homogeneous conditions are pressure 500bar / min, temperature 35-45°C, ...

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Abstract

The invention discloses an anti-glycation composition and a preparation method therefor and application of the anti-glycation composition, and belongs to the field of cosmetics. According to the anti-glycation composition, an Anoectochilus roxburghii extract, a ginkgo biloba leaf extract, hydroxytyrosol and panthenol are compounded in a specific ratio, so that effective ingredients including flavonoids, polyphenol and the like can better penetrate skin, and better exert an anti-glycation effect; the hydroxytyrosol and the panthenol are added on the basis of the Anoectochilus roxburghii extractand the ginkgo biloba leaf extract so as to make the anti-glycation composition disclosed by the invention into a nano-emulsion, and thus, penetrability of the effective ingredients can be further enhanced; and in addition, the nano-emulsion is filtered through a mesoporous silica nano-material, so that heavy metals, active oxygen and microorganisms in the nano-emulsion can be effectively removed, the safety of the nano-emulsion is enhanced and the shelf life of the nano-emulsion is extended.

Description

technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to an anti-glycation composition and its preparation method and application. Background technique [0002] Glycation reaction refers to the excess sugar that is free in the blood, attaches to collagen, undergoes condensation, rearrangement, and chain elongation reactions to generate highly reactive glycation intermediates; continues to interact with proteins to generate irreversible glycation end products (Advanced Glycation) end-products, AGEs). The cross-linking damage of proteins caused by the glycation reaction and the accumulation of AGEs and their binding to specific receptors cause a series of problems in the skin, such as decreased skin elasticity, wrinkles, dryness, relaxation, dark yellow and pigmentation. At the same time, it will also lead to the prolongation of the skin renewal cycle and the decline of the metabolic function of skin regeneration. Therefore, anti-g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/34A61K8/37A61K8/42A61K8/55A61K8/9771A61K8/9789A61Q19/02A61Q19/08
CPCA61K8/345A61K8/375A61K8/42A61K8/553A61K2800/592A61Q19/02A61Q19/08A61K8/9771A61K8/9789
Inventor 刘露张娇韩志东
Owner 泉后(广州)生物科技研究院有限公司
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