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A kind of preparation method of aromatic vinyl bromide derivative

A technology for aromatic vinyl and derivatives, which is applied in the field of preparation of aromatic vinyl bromide derivatives, can solve the problems of harsh reaction conditions, environmental pollution, and poor substrate compatibility of aromatic vinyl bromide derivatives, and achieves rich types and simple methods , the effect of convenient operation

Active Publication Date: 2021-09-03
HARBIN INSTITUTE OF TECHNOLOGY SHENZHEN (INSTITUTE OF SCIENCE AND TECHNOLOGY INNOVATION HARBIN INSTITUTE OF TECHNOLOGY SHENZHEN)
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Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of preparation method of aromatic vinyl bromide derivatives in order to solve the problems of harsh reaction conditions, poor substrate compatibility and environmental pollution in the synthesis of aromatic vinyl bromide derivatives in existing methods

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  • A kind of preparation method of aromatic vinyl bromide derivative
  • A kind of preparation method of aromatic vinyl bromide derivative
  • A kind of preparation method of aromatic vinyl bromide derivative

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specific Embodiment approach 1

[0012] Specific embodiment one: the preparation method of a kind of aromatic vinyl bromide derivative of this embodiment, carry out according to the following steps: At room temperature, under nitrogen atmosphere, alkyne derivative, brominated aromatic ring compound and catalyst are dissolved in organic In the solvent, after mixing evenly, place it under the light of blue LEDs for light reaction. After the reaction is completed, the solvent is evaporated, and then separated and purified by silica gel column chromatography to obtain aromatic vinyl bromide derivatives; among them, alkyne derivatives The molar ratio of the compound, the brominated aromatic ring compound and the catalyst is 2:1:0.2; the chemical structural formula of the alkyne derivative is: Among them, R 1 is a substituted aryl or alkyl group, R 2 It is a hydrogen atom or a carboxyl substituent; the chemical structural formula of brominated aromatic ring compounds is: Ar-Br; the catalyst is CuBr.

[0013] The...

specific Embodiment approach 2

[0019] Specific embodiment two: the difference between this embodiment and specific embodiment one is that the alkyne derivative is a phenylacetylene compound, an alkylacetylene compound or a propargyl acid compound. Others are the same as the first embodiment.

specific Embodiment approach 3

[0020] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: the brominated aromatic ring compound is 4-bromopyridine, 4-cyanobromobenzene or 4-ester bromobenzene. Others are the same as those in Embodiment 1 or 2.

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Abstract

A preparation method of aromatic vinyl bromide derivatives, the invention relates to a preparation method of aromatic vinyl bromide derivatives. The purpose of the present invention is to solve the problems of harsh reaction conditions, poor substrate compatibility and environmental pollution in the prior method for synthesizing aromatic vinyl bromide derivatives. The present invention synthesizes alkyne derivatives, bromoaromatic The cyclic compound and the catalyst are dissolved in the organic solvent, and the light reaction is carried out. After the reaction is completed, the solvent is rotated to evaporate, and the purification is completed; The problems of low yield, poor environmental protection and poor substrate compatibility caused by the catalytic system are applied in the field of organic synthesis.

Description

technical field [0001] The invention relates to a preparation method of aromatic vinyl bromide derivatives. Background technique [0002] Alkynes are a common class of functional structures found in a wide variety of valuable structural molecules. Because of its special structural skeleton, a large number of studies have been used to modify its skeleton structure. Difunctionalization of alkynes is one of the most important researches. Highly functionalized alkenes obtained by difunctionalization of alkynes are an important class of precursor structures for the synthesis of complex molecules. For the introduction of bromine atoms (Br) through the difunctionalization of alkynes in this research project, it has a wide range of applications in building materials, and is also a commonly used and valuable chemical transformation intermediate. [0003] At present, there are many research reports on the difunctionalization of alkyne derivatives. Among them, the atom transfer rad...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D213/26C07D409/06C07D213/30C07F7/08C07C253/30C07C255/50
CPCC07C253/30C07D213/26C07D213/30C07D409/06C07F7/0812C07C255/50
Inventor 夏吾炯赵馨鑫李冰苟宝权
Owner HARBIN INSTITUTE OF TECHNOLOGY SHENZHEN (INSTITUTE OF SCIENCE AND TECHNOLOGY INNOVATION HARBIN INSTITUTE OF TECHNOLOGY SHENZHEN)
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