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Compound solid compositions containing phenylephrine bitartrate and aspirin, preparation and application thereof

A technology of phenylephrine and solid composition, which is applied in the direction of medical preparations containing active ingredients, drug combinations, anti-inflammatory agents, etc., and can solve problems such as unreasonable composition, degradation of active ingredients, and discoloration of liquid medicine

Pending Publication Date: 2020-09-29
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] If multiple symptoms occur, such as fever, nasal congestion and headache, etc., the above-mentioned single active drugs with different effects can be combined to prepare suitable products. However, if different drug active ingredients are combined to prepare Different products need to consider the characteristics and stability of drugs. Therefore, how to combine active drugs or prepare dosage forms is a challenging task. Specifically, when preparing oral liquids, due to unreasonable formulations or The process conditions of its preparation are not considered during the preparation, which will cause the color of the liquid medicine to change or the active ingredient to degrade

Method used

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  • Compound solid compositions containing phenylephrine bitartrate and aspirin, preparation and application thereof
  • Compound solid compositions containing phenylephrine bitartrate and aspirin, preparation and application thereof
  • Compound solid compositions containing phenylephrine bitartrate and aspirin, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] prescription

[0050]

[0051]

[0052] Preparation method:

[0053] 1. Mixing of active ingredients: Take the prescribed amount of aspirin and dextromethorphan hydrobromide and mix evenly, then add phenylephrine tartrate in equal increments while stirring, after stirring evenly, keep away from light and airtight to obtain active ingredients Ingredient mix powder, set aside;

[0054] 2. Preparation of acid granules: take half of the above mixed powder, add the prescribed amount of citric acid and sucrose and mix evenly, add part of polyvinylpyrrolidone aqueous solution to make soft material, granulate to obtain acid granules, and set aside;

[0055] 3. Preparation of alkali granules: Take half of the above mixed powder, add anhydrous sodium carbonate of the prescribed amount, mix well, add the remaining polyvinylpyrrolidone aqueous solution to make a soft material, granulate to obtain alkali granules, and set aside;

[0056] 4. Mix the above-mentioned acid granu...

Embodiment 2

[0058] prescription:

[0059] material name Proportion: 500g contains (W) Phenylephrine Bitartrate 7.8 aspirin 325 Chlorpheniramine maleate 2 citric acid 50 Anhydrous Sodium Carbonate 50 dextrin 62 Hydroxypropylmethylcellulose 3 Micropowder silica gel 0.2

[0060] Preparation method:

[0061] 1. Mixing of active ingredients: After taking the prescribed amount of aspirin and chlorpheniramine maleate and mixing them evenly, add phenylephrine tartrate in equal increments under stirring, after stirring evenly, keep away from light and airtight to obtain Active ingredient mixed powder, set aside;

[0062] 2. Preparation of acid granules: Take one-half of the mixed powder of the above active ingredients, add the prescribed amount of citric acid and dextrin and mix evenly, add part of the soft material made of hydroxypropyl methylcellulose, and granulate to obtain acid Granules, spare;

[0063] 3. Preparation of alkali...

Embodiment 3

[0066] prescription:

[0067] material name Proportion 1000g contains (W) Phenylephrine Bitartrate 7.8 aspirin 500 Dextromethorphan Hydrobromide 10 doxylamine succinate 6.25 citric acid 50 Anhydrous Sodium Carbonate 50 sucrose 372.75 Aqueous solution of polyvinylpyrrolidone 3 Micropowder silica gel 0.2

[0068] Preparation method:

[0069] 1. Mixing of active ingredients: take the prescribed amount of aspirin, dextromethorphan hydrobromide, and doxylamine succinate and mix evenly, then add phenylephrine tartrate in equal increments while stirring, and mix well , protected from light, airtight, to obtain active ingredient mixed powder, and set aside;

[0070] 2. Preparation of acid granules: Take half of the mixed powder of the above active ingredients, add the prescribed amount of citric acid and sucrose and mix evenly, add part of polyvinylpyrrolidone aqueous solution to make soft material, granulate to obt...

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Abstract

The invention relates to compound solid compositions containing norepinephrine bitartrate and aspirin, a preparation and application thereof. The following four compositions are included: 1, a combination of norepinephrine bitartrate, aspirin and dextromethorphan hydrobromide; 2, a combination of phenylephrine bitartrate, aspirin and chlorpheniramine maleate; 3, a combination of phenylephrine bitartrate, aspirin, dextromethorphan hydrobromide and doxylamine succinate; and 4, a combination of phenylephrine bitartrate, aspirin, chlorpheniramine maleate and dextromethorphan hydrobromide. The preparation dosage form of the compositions is effervescent tablets. According to different active ingredients in the compositions, the effects of the compositions are different, however the compositionscan all relieve the following symptoms caused by cold: slight pain, headache, rhinorrhea and sore throat, and can temporarily relieve fever and the like. The compound solid compositions provided by the invention are an effective drugs for treating respiratory diseases caused by viruses or germs, including various diseases.

Description

technical field [0001] The present invention belongs to the field of drug research and development, and specifically relates to a compound solid composition comprising phenylephrine bitartrate and aspirin for the treatment of respiratory diseases and cold symptoms, as well as its preparation and use, more specifically the solid composition involved in the present invention Contains phenylephrine bitartrate with a pressor effect, aspirin with antipyretic and analgesic effects, and antitussive or antiallergic drugs. Background technique [0002] Respiratory diseases include a variety of diseases, mostly caused by viruses or germs, such as colds and flu, and allergic rhinitis. The symptoms mainly include fever, nasal congestion, runny nose, cough, sneezing or headache. Many complications bring serious harm to people's health. [0003] Pharmaceutical active substances commonly used to treat the above symptoms generally belong to one of the following drug categories, antihistami...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61K31/137A61K31/485A61K31/4402A61K9/20A61P11/00A61P29/00A61P21/00A61P11/02A61P11/04A61P31/12A61P31/04
CPCA61K9/0007A61K9/2027A61K9/2054A61K31/137A61K31/4402A61K31/485A61K31/616A61P11/00A61P11/02A61P11/04A61P21/00A61P29/00A61P31/04A61P31/12A61K2300/00
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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