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Zinc hyaluronate-containing private care packing suppository and preparation method thereof

A technology of zinc hyaluronic acid and cross-linked hyaluronic acid, which is applied to medical preparations containing active ingredients, suppository delivery, medical preparations with no active ingredients, etc., to reduce water loss, maintain growth and reproduction, and inhibit bacteria the effect of growth

Active Publication Date: 2020-10-02
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no vaginal personal care products that do not use antibiotics and other drugs and can treat vaginal inflammation, regulate vaginal flora, and reduce the recurrence of vaginal inflammation.

Method used

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  • Zinc hyaluronate-containing private care packing suppository and preparation method thereof
  • Zinc hyaluronate-containing private care packing suppository and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The formulation of private care tampon suppository containing zinc hyaluronate is as follows (wt%): zinc hyaluronate (cross-linked zinc hyaluronate: high molecular weight zinc hyaluronate: ultra-low molecular weight zinc hyaluronate = 1:1:1, w / w / w) 0.5%, sucrose 15%, lactic acid 0.2%, rose 10%, glycerin 30%, gelatin 30%, and the balance is water. Wherein, the preparation method of the cross-linked zinc hyaluronate is: zinc hyaluronate with a molecular weight of 1 million Da to 1.5 million Da and a cross-linking agent 1,4-butanediol diglycidyl ether according to the ratio of 1:0.03-0.05 The mass ratio is added to water, the pH is adjusted to 8.0-9.0, cross-linked at 30-35°C for 3-5 hours, and then washed with water to remove impurities and other post-treatments to obtain cross-linked zinc hyaluronate. The molecular weight of the high molecular weight zinc hyaluronate used is 1 million Da to 2 million Da, and the molecular weight of the ultralow molecular weight zinc hyal...

Embodiment 2

[0043] The formulation of private care tampon suppository containing zinc hyaluronate is as follows (wt%): zinc hyaluronate (cross-linked zinc hyaluronate: high molecular weight zinc hyaluronate: ultra-low molecular weight zinc hyaluronate = 1:1:1, w / w / w) 1%, sucrose 20%, lactic acid 0.5%, rose 10%, glycerin 35%, gelatin 20%, and the balance is water. The cross-linked zinc hyaluronate, high-molecular-weight zinc hyaluronate and ultra-low-molecular-weight zinc hyaluronate used are the same as in Example 1.

[0044] The preparation method is the same as in Example 1.

Embodiment 3

[0046]The formulation of private care tampon suppository containing zinc hyaluronate is as follows (wt%): zinc hyaluronate (cross-linked zinc hyaluronate: high molecular weight zinc hyaluronate: ultra-low molecular weight zinc hyaluronate = 1:1:1, w / w / w) 2%, sucrose 30%, lactic acid 1%, rose 10%, glycerin 40%, gelatin 10%, and the balance is water. The cross-linked zinc hyaluronate, high-molecular-weight zinc hyaluronate and ultra-low-molecular-weight zinc hyaluronate used are the same as in Example 1.

[0047] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a zinc hyaluronate-containing private care packing suppository and a preparation method thereof. The zinc hyaluronate-containing private care packing suppository contains zinchyaluronate, carbohydrates, lactic acid, glycerin, gelatin and water. The private care packing suppository is used for female private part care, a layer of film can be formed on the inner surface of the vagina, harmful bacteria are inhibited, nutrient substances are provided for beneficial bacteria in the vagina, and therefore the effects of resisting bacteria, diminishing inflammation, lubricating, preserving moisture and promoting lactobacillus to become dominant strains are achieved.

Description

technical field [0001] The invention relates to a personal protection tampon suppository containing zinc hyaluronate and a preparation method thereof, belonging to the technical field of female personal protection products. Background technique [0002] Bacterial vaginosis, candida vaginitis, trichomonas vaginitis and other vaginitis are diseases that many women are difficult to talk about but cannot be ignored. At present, the personal care products on the market are mainly antibiotics. The use of antibiotics will not only kill pathogenic bacteria, but also kill symbiotic bacteria such as Lactobacillus that maintain the vaginal microenvironment. The phenomenon that gynecological diseases can not be cured for a long time. Now, personal care gel products that sell garbage toxins are popular among female friends. However, some personal care gel products only kill a large number of vaginal wall cells, and the "garbage toxins" discharged are actually the shed cervix. The epide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K47/42A61K47/10A61K31/19A61K31/728A61K31/7016A61P15/02A61P31/04A61P31/10A61P33/02
CPCA61K9/02A61K9/0034A61K47/42A61K47/10A61K31/19A61K31/728A61K31/7016A61P15/02A61P31/04A61P31/10A61P33/02A61K2300/00Y02A50/30
Inventor 于鲁孟乔莉苹冯宁石艳丽郭学平王珊珊周宁刘福全宗文斌
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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