DC vaccine for novel corona viruses, and preparation method and application of DC vaccine

A coronavirus and vaccine technology, applied in the field of biomedicine, can solve problems such as the lack of DC vaccines, and achieve the effects of improving the killing effect, quick start, and shortening the time
CN111729079AInactive Publication Date: 2020-10-02SHANDONG XINRUI BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANDONG XINRUI BIOTECH CO LTD
Publication Date
2020-10-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a DC vaccine for novel corona viruses. The DC vaccine comprises COVID-19 S proteins, chemotactic factors CCL19. The DC vaccine prepared from self peripheral blood is high in safety and does not have exclusive reactions. Compared with other vaccines, the DC vaccine is longer in duration time, can faster recognize antigens, can start up killing and damaging functions of T cells, and can produce antibodies at the same time. During in vitro tests, when the DC vaccine is united with CIK, killing and damaging to target cells can be started within 4h. The 2019nCOV-S-CCL19 DC vaccine prepared by the invention is united with the CIK cells to achieve good killing and damaging experiment effects; in vitro tests, when the 2019nCOV-S-CCL19 DC vaccine is united with the CIK cellsfor use, the 2019nCOV-S-CCL19 DC vaccine, the CIK cells and target cells are mixed for 24h, then detection is performed, when an effector target ratio is 10:1, the cytotoxicity to the target cells isas high as 93.2%, and when the effector target ratio is 5:1, the cytotoxicity to the target cells is as high as 68.6%.
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Description

technical field

[0001] The invention relates to a DC vaccine against novel coronavirus, a preparation method and application thereof, and belongs to the technical field of biomedicine. Background technique

[0002] Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) and play an important role in regulating innate and adaptive immune responses. In their immature state, DCs patrol the tissue microenvironment and become activated in the presence of foreign pathogens. This activation occurs following stimulation by exogenous danger signals through pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) and leads to migration of DCs to draining lymph nodes and presentation of processed epitopes to T cells. During T cell activation, DCs bind to the T cell receptor (TCR), secrete specific cytokines, and stimulate immune responses to TH1, TH2, or Tregs depending on the cytokine environment.

[0003] The latest research shows that ...

Claims

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