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Antibacterial anticoagulant coating, preparation method thereof and medical material

An anticoagulant and coating technology, applied in coatings, medical science, pharmaceutical formulations, etc., can solve the problems of drug resistance, poor blood compatibility of antibiotics, etc., and improve the complications of infection and thrombus, Effect of good anticoagulant and antibacterial effect

Active Publication Date: 2020-10-13
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this treatment method will cause a series of adverse reactions, such as: poor blood compatibility of antibiotics, drug resistance problems; thrombocytopenia and bleeding caused by heparin injection

Method used

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  • Antibacterial anticoagulant coating, preparation method thereof and medical material
  • Antibacterial anticoagulant coating, preparation method thereof and medical material
  • Antibacterial anticoagulant coating, preparation method thereof and medical material

Examples

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preparation example Construction

[0053] The embodiment of the present invention also provides a preparation method of the above-mentioned antibacterial and anticoagulant coating, which includes the following steps: using macrocyclic molecules to graft metal ions on the coating substrate, and using azide compounds to graft antibacterial polypeptide molecules on the coating base.

[0054] Specifically, the preparation method may be as follows: performing an amide reaction on the macrocyclic molecule and the azide compound with the coating substrate, so that the macrocyclic molecule and the azide compound are bonded to the coating substrate; and then chelating the metal ion and the macrocyclic molecule The combination reaction makes the metal ion and the macrocyclic molecule chelate, and the antibacterial polypeptide molecule and the azide compound undergo a click chemical reaction, so that the antibacterial polypeptide molecule and the azide compound are linked.

[0055] The preparation method is to respectivel...

Embodiment 1

[0065] Embodiments of the present invention provide a method for preparing an antibacterial and anticoagulant coating, comprising the following steps:

[0066] First, synthesize the polymer (number PAMCA):

[0067] Specifically, use UP water to prepare a sufficient amount of MES buffer solution (9.6mg / mL), add an appropriate amount of NaOH to adjust its pH to 5.4, and then use high-purity nitrogen to remove oxygen dissolved in the MES solution, and the deoxygenated MES solution is ready for use. Then use a ten-thousandth balance to weigh a certain amount of HCA, EDC, and NHS, and prepare 0.6mg / mL, 1.5mg / mL, and 0.75mg / mL solutions with deoxygenated MES buffer solution, and react at 20°C for 30min . Then polyallylamine (PAM) solution was added dropwise to the reaction system to make the concentration in the reaction solution 1 mg / mL, and the reaction was continued at 37° C. for 24 h. During the reaction process, nitrogen gas was used to remove oxygen throughout the process. A...

Embodiment 2- Embodiment 3

[0076] Embodiment 2-embodiment 3 provides a kind of preparation method of antibacterial anticoagulant coating, and this preparation method is identical with the preparation method that embodiment 1 provides, and difference is that specific operating conditions are different, specifically as follows:

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PUM

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Abstract

The invention relates to the technical field of medical materials, in particular to an antibacterial anticoagulant coating, a preparation method thereof and a medical material. The antibacterial anticoagulant coating is provided with anticoagulant metal ions, antibacterial polypeptide molecules and a coating substrate; the metal ions are grafted to the coating substrate through macrocyclic molecules; and the antibacterial polypeptide molecules are grafted to the coating substrate through azide compounds. The antibacterial and anticoagulant coating has good antibacterial and anticoagulant effects, and can well improve postoperative infection and thrombus complications of blood contact biological materials.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an antibacterial and anticoagulant coating, a preparation method thereof and a medical material. Background technique [0002] Blood-contact biomaterials are a type of implantable materials used in clinical practice, which can treat, replace or enhance tissue functions. Blood-contacting medical devices include short-term exposure to blood, such as guidewires, catheters, and circuit wires used in hemodialysis or cardiopulmonary bypass, and long-term blood-contacting devices, including vascular access grafts and long-term implanted devices such as stents , heart valves, left ventricular assist devices and artificial hearts. The use of blood-contacting materials can create multiple complications, among which postoperative infection and thromboembolism are by far the most common and need to be addressed. At present, for these two complications clinically, antibiotics and ...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/08A61L31/14A61L31/16
CPCA61L31/08A61L31/088A61L31/10A61L31/14A61L31/16A61L2300/102A61L2300/252A61L2300/404A61L2300/42A61L2400/18A61L2420/02A61L2420/04A61L2420/06C08L89/00C08L39/00
Inventor 黄楠于绍兴杨志禄涂秋芬熊开琴高鹏邱华
Owner SOUTHWEST JIAOTONG UNIV
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