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Application of tropisetron in preparation of daily chemicals or medicines for improving skin

A technology for improving the skin, tropisetron, which is applied in the application field of daily chemicals or medicines, can solve problems such as accelerated decomposition and denaturation of skin substances, skin photodamage, and fragile skin barrier, so as to prevent and treat nausea and vomiting, improve skin effect

Pending Publication Date: 2020-10-16
PLASTIC SURGERY HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Due to many internal and external reasons, various problems occur in the skin, such as photodamage to the skin caused by excessive exposure to sunlight, the increase of active oxygen species accelerates the decomposition and denaturation of the substances that make up the skin, various skin inflammations, etc., making the skin barrier become vulnerable while causing all sorts of distress for people

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Prove the anti-ultraviolet effect of tropisetron.

[0014] (1) Select 40 healthy male rats with a weight of about 140g (the weight difference does not exceed 5g).

[0015] (2) Randomly divide 40 male rats into experimental group and control group.

[0016] (3) Anesthetize 40 rats.

[0017] (4) Shave the skin of the rat's back after anesthesia, exposing an area of ​​about 3cm×3cm.

[0018] (5) Irradiate the back of the rat with an ultraviolet lamp for 5 days (the distance between the back of the rat and the ultraviolet lamp during the irradiation is 55cm, and the irradiation time per day is 1h). After 5 days of irradiation, it was observed that there was very obvious redness and swelling of the skin in the irradiated area, and increased skin fragmentation. HE staining revealed that the cuticle of the wound was necrotic and fell off, and the dermis was thickened and edema. The condition of dermal collagen fibers was evaluated by Sirius scarlet and Masson's trichrome staining. Ul...

Embodiment 3

[0032] Prove the anti-inflammatory effect of tropisetron

[0033] In this example, tropisetron was used to conduct efficacy clinical trials.

[0034] Number of subjects: 20

[0035] Distribution: 10 persons each for oily and dry skin types

[0036] Application method: smear

[0037] Application site: acne sites such as forehead, chin, cheek, etc.

[0038] Application time: Apply to the extent of covering the skin after washing your face every morning and evening

[0039] Experiment time: 4 weeks later

[0040] Test index: Test whether there is a treatment or improvement effect on dermatitis, which is characterized by improvement rate

[0041] Lesion definition: papules, localized proliferation of epidermal or dermal cell components or localized cell infiltration of the dermis, and the appearance of red skin bulges; pustules, a localized bulge on the skin containing pus, which is body tissue Thick or thin exudate formed during inflammation; nodules, similar in shape to papules, with a large...

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PUM

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to an application of tropisetron in preparation of daily chemicals or medicines for improving skin, and the tropisetron is used for improving skin. Tropisetron is used for preventing and treating nausea and vomiting caused by cancer chemotherapy. The inventor accidentally finds that the tropisetron has an excellenteffect of improving the skin, so that the skin of a human body can better exert the function of a first organism protective film.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the application of tropisetron in the preparation of daily chemicals or medicines for improving skin. Background technique [0002] Tropisetron is also known as topsyrone, and vomiting must stop. Traditionally, tropisetron is a highly selective inhibitor of 5-HT3 receptors in peripheral neurons and central nervous system. Anticancer drugs or radiotherapy can stimulate the chromaffin cells of the small intestine mucosa to release 5-HT3, induce the vomiting reflex, and cause nausea and vomiting. Tropisetron selectively inhibits the excitement of presynaptic 5-HT3 receptors in the peripheral nervous system in this reflex, and may have 5-HT in the central nervous system. The post-afferent area of ​​the vagus nerve transmitted by the receptor has a direct effect. This dual effect blocks the chemical transmission of nerve mediators in the process of the vomiting reflex, thereb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61Q19/00A61K31/46A61P17/00A61P17/10A61P37/08A61P17/08
CPCA61K8/4926A61Q19/00A61Q19/004A61K31/46A61P17/00A61P17/10A61P37/08A61P17/08A61K2800/522
Inventor 王长琛潘博蒋海越
Owner PLASTIC SURGERY HOSPITAL CHINESE ACAD OF MEDICAL SCI
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