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Preparation method and quality control method of physalis alkekengi extract with anti-inflammatory effect

A quality control method and extract technology, applied in the direction of medical preparations containing active ingredients, anti-inflammatory agents, measuring devices, etc., can solve the problems of complex process, lengthy process, pollution, etc., and achieve simple process, obvious activity, Extraction solvent single safe effect

Active Publication Date: 2020-10-30
YUNNAN BOTANEE BIO TECH GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

High toxicity, often not conducive to large-scale production, pollution will be generated during the production process, and the introduced toxic reagents need to be removed afterwards, the process is lengthy and complicated

Method used

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  • Preparation method and quality control method of physalis alkekengi extract with anti-inflammatory effect
  • Preparation method and quality control method of physalis alkekengi extract with anti-inflammatory effect
  • Preparation method and quality control method of physalis alkekengi extract with anti-inflammatory effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] An embodiment of the present invention, a preparation method of Physalis extract with anti-inflammatory effect, comprises the following steps:

[0050] S1, crushing and sieving step: dry and crush the persistent calyx of Physalis physalis, and pass through No. 4 to No. 8 sieves;

[0051] S2, the step of preparing the extract: accurately weigh 100 g of the pulverized calyx physalis, place it in a 1000 mL flask, accurately add 500 mL of ethanol aqueous solution with a volume concentration of 50%, heat and reflux for 1 hour, and extract 3 times at a heating temperature of 80°C. Combine the filtrates and filter while hot to obtain the extract;

[0052] S3, concentrating step: combining the extracts and concentrating under reduced pressure until there is no alcohol smell to obtain a concentrated solution;

[0053] S4, freeze-drying step: using a freeze-dryer to dry the concentrated solution at low temperature to obtain a solid Physalis extract, and the calculated yield is 16....

Embodiment 2

[0088] A preparation method of Physalis extract with anti-inflammatory effect, comprising the following steps:

[0089] S1, crushing and sieving step: dry and crush the persistent calyx of Physalis physalis, and pass through No. 4 to No. 8 sieves;

[0090] S2, the step of preparing the extract: accurately weigh 50 g of the pulverized calyx physalis, place it in a 1000 mL flask, accurately add 400 mL of ethanol aqueous solution with a volume concentration of 80%, heat and reflux for 2 hours, extract once, and heat at 60°C. Filter while hot to obtain the extract;

[0091] S3, concentrating step: combining the extracts and concentrating under reduced pressure until there is no alcohol smell to obtain a concentrated solution;

[0092] S4, freeze-drying step: use a freeze-dryer to dry the concentrated solution at low temperature to obtain a solid Physalis extract, and the calculated yield is 18.44%;

[0093] An appropriate amount of the physalis extract obtained by freeze-drying ...

Embodiment 3

[0103] A preparation method of Physalis extract with anti-inflammatory effect, comprising the following steps:

[0104] S1, crushing and sieving step: dry and crush the persistent calyx of Physalis physalis, and pass through No. 4 to No. 8 sieves;

[0105] S2, the step of preparing the extract: accurately weigh 10 g of the pulverized calyx physalis, place it in a 100 mL flask, accurately add 60 mL of ethanol aqueous solution with a volume concentration of 60%, heat and reflux for 3 hours, and extract 3 times at a heating temperature of 70°C. Combine the filtrates and filter while hot to obtain the extract;

[0106]S3, concentrating step: combining the extracts and concentrating under reduced pressure until there is no alcohol smell to obtain a concentrated solution;

[0107] S4, freeze-drying step: using a freeze-dryer to dry the concentrated solution at a low temperature to obtain a solid Physalis extract, and the calculated yield is 15.62%.

[0108] A method for quality co...

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Abstract

The invention discloses a preparation method of a physalis alkekengi extract with an anti-inflammatory effect. The preparation method comprises the steps of crushing and sieving, extracting solution preparation, concentration and freeze drying. The method has the advantages of simple process, single and safe extraction solvent, recoverability, no introduction of toxic reagents, no pollution to theenvironment, facilitation of large-scale production, no redundant steps, no pollution to the environment, and obvious activity of prepared substances, and can be used as an active component of functional skincare products and medical auxiliary articles to play roles in resisting inflammation, relieving allergy and the like. The invention further discloses a quality control method of the physalisalkekengi extract with the anti-inflammatory effect, the luteoloside content serves as the quality evaluation standard of the physalis alkekengi extract, reasonability is achieved, and the method is reliable.

Description

technical field [0001] The invention relates to a preparation method and quality control method of Physalis extract with anti-inflammatory effect. Background technique [0002] Physalis (Jin Lantern) is the dry suzun or persistent calyx with fruit of Solanaceae plant Physalis (Ph.alkekengi L.var.franchetii (Mast.) Makino). The fruit is a spherical berry, which is orange-red when ripe, and has an enlarged calyx loosely surrounding the berry like a lantern, so it is also known as Red Girl and Hanging Golden Lantern. It was first included in "Shen Nong's Materia Medica", and it was listed as a middle-grade product. Its traits and efficacy are recorded in ancient herbal medicine. Physalis fruit is rich in nutrients and has good edible value. In the late autumn or early winter, the folks in the north will hang the Physalis fruit in strings under the eaves, and eat the berries after frost. [0003] Chemical Composition Research: [0004] In recent years, there have been many m...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61P29/00G01N30/02
CPCA61K36/81A61P29/00G01N30/02A61K2236/15A61K2236/331A61K2236/333A61K2236/51
Inventor 邓亚雷曲丽萍王飞飞袁永雷马骁高绍阳郭振宇
Owner YUNNAN BOTANEE BIO TECH GRP CO LTD
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