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Method for increasing the lifespan and motility of animal sperm using an inhibitor of slo3 potassium channel

A potassium channel inhibitor and motility technology, which is applied in the field of artificial insemination tools and motility of capacitated sperm, and can solve the problems of semen quality, oocyte fertilization ability, etc.

Active Publication Date: 2020-10-30
IMV TECH +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although necessary, capacitation results in irreversible changes to spermatozoa and ultimately reduces semen quality, motility, and ability to fertilize oocytes

Method used

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  • Method for increasing the lifespan and motility of animal sperm using an inhibitor of slo3 potassium channel
  • Method for increasing the lifespan and motility of animal sperm using an inhibitor of slo3 potassium channel
  • Method for increasing the lifespan and motility of animal sperm using an inhibitor of slo3 potassium channel

Examples

Experimental program
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Embodiment approach

[0066] - said contacting step is performed in a female by administering a Slo3 potassium channel inhibitor composition in said female's vagina and / or cervix, and said artificial insemination step is insemination of said female with sperm from said animal; and / or

[0067] - said contacting step is carried out in a male, preferably by injection into the epididymis or testis of said male, and said artificial insemination step is the insemination of a female by spermatozoa of said animal; and / or

[0068] - said artificial insemination step is performed using an artificial insemination tool; and / or

[0069] - The artificial insemination step is performed by using a semen pipette for cryopreservation.

[0070] The freezing medium in the pipette of the invention preferably comprises generally suitable additives known to those skilled in the art, for example at least one cryoprotectant (e.g. alcohols (glycerol, propylene glycol), aldehydes (formamide), sugars (sucrose, cotton suga...

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Abstract

The invention relates to a method for increasing the lifespan of animal sperm comprising contacting said sperm with an inhibitor of Slo3 potassium channel. The invention also relates to a use of an inhibitor of Slo3 potassium channel, for increasing the lifespan of animal sperm or motility of capacitated animal sperm, comprising contacting an inhibitor of Slo3 potassium channel with said sperm. Moreover, the invention relates to an artificial insemination instrument for use in artificial insemination of an animal, comprising animal sperm in contact with an inhibitor of Slo3 potassium channel.The invention also relates to a method for artificially inseminating an animal using said artificial insemination instrument. Eventually, the invention relates to a method for increasing the fertilityof an animal, comprising contacting sperm of said animal with an inhibitor of Slo3 potassium channel; then artificially inseminating said animal with said sperm.

Description

technical field [0001] The present invention relates to increasing the longevity of animal (ie, non-human) sperm. The present invention also relates to improving the motility of animal sperm, especially capacitated sperm. The invention also relates to an artificial insemination tool for artificial insemination of animals, a method for artificial insemination of animals and a method for increasing the fertility of animals. Background technique [0002] The prevalence of artificial insemination (AI), in which sperm is deposited in the vagina or uterus of females to enhance the utilization of the semen of males of high genetic value, is approaching 100% in dairy cow breeding. However, the conception rate for artificial insemination of cattle has declined over the past two decades. A major factor in low conception rates is the inability to pinpoint when ovulation occurs. [0003] When conception fails, repeated artificial insemination, such as artificial insemination of femal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02G01N33/50
CPCA01N1/0221A01N1/0226G01N33/502A61D19/024A61D19/027A61K31/14A61K31/4748
Inventor C·阿尔努E·施米特G·马丁内斯J·埃斯科菲耶
Owner IMV TECH