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Carnitine sustained-release preparation and preparation method thereof

A sustained-release preparation and carnitine technology, applied in the field of carnitine sustained-release preparations and its preparation, can solve the problems of infant injury, unsuitability for infants, hidden safety hazards, etc. Good effect, no safety hazard effect

Active Publication Date: 2020-11-03
CENT SOUTH UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The above-mentioned technology has added too many medicinal excipients, which may cause harm to infants and young children, and has potential safety hazards, so it is not suitable for infants and young children.

Method used

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  • Carnitine sustained-release preparation and preparation method thereof
  • Carnitine sustained-release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] 53g of L-carnitine (L-carnitine), 536g of whey protein concentrate obtained by adjusting the protein content to 34wt% and spray drying (solid content of whey protein concentrate: 97wt%, wherein, defatted Milk solids content is: 96wt%, fat content is: 1wt%, the total content of lactalbumin and lactoglobulin is about 66wt%), obtain from MeijiCo., Ltd.) and the water of 1810g is put into turbo mixer (by Scanima manufacturing) to obtain a mixture, and then heat the mixture to 55° C., stir and dissolve at a speed of 2500 rpm, and perform mechanical shearing treatment to obtain a whey protein solution with a pH of 4.6. The heat treatment and the mechanical shearing treatment are continued, and when the temperature of the whey protein solution reaches 85° C., the mechanical shearing treatment is continued at 85° C. for 25 minutes to aggregate the whey protein. Then stop the heat treatment, and turn on the cooling system, and continue the mechanical shearing treatment at 2500 r...

Embodiment 2

[0051] 53 g of L-carnitine (L-carnitine), 536 g of whey protein concentrate obtained by adjusting the protein content to 34 wt% and spray drying (solid content of whey protein concentrate: 97% by weight, wherein, Skim milk solid content: 96% by weight, fat content: 1% by weight, total content of lactalbumin and lactoglobulin about 40%), obtained from Meiji Co., Ltd.) and 1810 g of water were put into a turbo-mix (manufactured by Scanima) to mix the mixture, then the mixture was heated to 55° C., stirred and dissolved at a speed of 2500 rpm, and mechanically sheared to obtain a whey protein solution with a pH of 4.7. The heat treatment and the mechanical shearing treatment are continued, and when the temperature of the whey protein solution reaches 85° C., the mechanical shearing treatment is continued at 85° C. for 25 minutes to aggregate the whey protein. Then stop the heat treatment, and turn on the cooling system, and continue the mechanical shearing treatment at 2500 rpm u...

Embodiment 3

[0054] The L-carnitine (L-carnitine) of 110g, the whey protein concentrate (wherein the total content of lactalbumin and lactoglobulin is about 80%) and the water of 1210g are put into turbo mixer ( manufactured by Scanima) to obtain a mixture, then the mixture was heated to 55° C., stirred and dissolved at a speed of 2500 rpm, and mechanically sheared to obtain a whey protein solution with a pH of 4.8. The heat treatment and the mechanical shearing treatment are continuously performed, and when the temperature of the whey protein solution reaches 75° C., the mechanical shearing treatment is continuously performed at 75° C. for 60 min to aggregate the whey protein. Then stop the heat treatment, and turn on the cooling system, and continue the mechanical shearing treatment at 2500 rpm until the temperature drops below 40° C., stop the mechanical shearing treatment, and obtain whey protein aggregates.

[0055] The D50 of the whey protein aggregate particles thus obtained is 4.5 ...

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Abstract

The invention provides a carnitine sustained-release preparation and a preparation method thereof. The carnitine sustained-release preparation comprises carnitine and a whey protein aggregate, whereinthe mass proportion of the carnitine is 0.1-20 wt%, 50% of the whey protein aggregate has particles with average particle size of 2-10 [mu] m, and at least 30 wt% of the carnitine is dispersed in whey protein aggregate particles. The carnitine sustained-release preparation mainly consists of natural food components and can be prepared through simple treatment namely heat treatment and mechanicalshearing treatment which are simultaneously performed, a pH regulator is not used, and the carnitine sustained-release preparation basically does not contain a stabilizer, an emulsifier or other synthetic additives and is a product with high natural appearance. The carnitine sustained-release preparation has good fragrance and food feeling, basically has no potential safety hazard, and is particularly suitable for infants and young children. The carnitine sustained-release preparation has a carnitine sustained-release effect, the use frequency of the carnitine sustained-release preparation inone day is greatly reduced, and the plasma-drug concentration of the carnitine is stable.

Description

technical field [0001] The invention relates to the field of sustained-release preparations, in particular to a carnitine sustained-release preparation and a preparation method thereof. Background technique [0002] L-carnitine has been used in the fields of medicine, health care and food, and has been regulated as a legal multi-purpose nutritional agent by Switzerland, France, the United States and the World Health Organization. my country's food additive hygiene standard GB2760-1996 stipulates that L-carnitine tartrate is a food nutrition enhancer, which can be used in chewable tablets, drinking liquids, capsules, milk powder and milk drinks. And can be used as one of the main components of nutritional food for weight loss. [0003] Especially L-carnitine has been used in the treatment of diseases in infants and young children, such as canned powder or solution, -1 for infants and young children with type Ⅰ, Ⅱ, Ⅲ tyrosinemia, -1, suitable for infants with maple syrup ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/175A23L33/19A23P10/40
CPCA23L33/175A23L33/19A23P10/40A23V2002/00A23V2200/30A23V2250/0612A23V2250/54252
Inventor 付劼丁劲松周文虎徐增松夏鹤均
Owner CENT SOUTH UNIV
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