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Preparation method of hydrophilic lubricating coating on surface of PVC catheter

A technology for lubricating coatings and catheters, applied in catheters, coatings, etc., to achieve the effects of convenient use, simple equipment and good coating stability

Inactive Publication Date: 2020-11-03
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the coating method is also restricted by the adhesion of the coating, the side effects or drug resistance of the coating, and the production method.

Method used

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  • Preparation method of hydrophilic lubricating coating on surface of PVC catheter
  • Preparation method of hydrophilic lubricating coating on surface of PVC catheter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Treat PVC catheter with oxygen plasma for 50s; immerse in Tris-Hcl buffer solution (Tris concentration = 0.01mol / L) with PH=8-9 and dopamine concentration of 2mg / ml to modify at room temperature for 24h; The dopamine-modified urinary catheter was soaked for 30 minutes, and washed three times with deionized water; the cleaned urinary catheter was placed in the above-mentioned Tris-Hcl buffer with an amino PEG concentration of 2 mg / ml, and modified at a constant temperature of 50°C for 24 hours.

Embodiment 2

[0032] Treat PVC catheter with oxygen plasma for 50s; immerse in Tris-Hcl buffer solution (Tris concentration = 0.01mol / L) with PH=8-9 and dopamine concentration of 2mg / ml to modify at room temperature for 28h; The dopamine-modified urinary catheter was soaked for 30 minutes, and washed three times with deionized water; the cleaned urinary catheter was placed in the above-mentioned Tris-Hcl buffer with an amino-PVA concentration of 1 mg / ml, and modified at a constant temperature of 50°C for 12 hours.

Embodiment 3

[0034] Treat PVC catheter with oxygen plasma for 30s; immerse in Tris-Hcl buffer solution (Tris concentration = 0.01mol / L) with PH=8-9 and dopamine concentration of 2mg / ml for modification at room temperature for 6h; Soak the dopamine-modified urinary catheter for 30 minutes, and wash it three times with deionized water; put the cleaned urinary catheter into the above-mentioned Tris-Hcl buffer solution with an amino PEG concentration of 1.5 mg / ml, and modify it at a constant temperature of 50°C for 6 hours .

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Abstract

The invention discloses a preparation method of a hydrophilic lubricating coating on the surface of a PVC catheter. Firstly, the PVC catheter is subjected to oxygen plasma treatment, then dopamine coating modification is carried out, a polydopamine layer is deposited on the surface layer of the PVC catheter, and finally, graft modification by utilizing an amino-containing hydrophilic lubricating polymer material namely amino-containing PEG or PVA. By means of Michael addition or Schiff's Base principle, amino-containing hydrophilic lubricating macromolecules and the polydopamine layer form covalent bonds, so that the amino-containing hydrophilic lubricating macromolecules are firmly bonded to the surface of the PVC catheter. The dopamine has very high biocompatibility, and the polydopaminelayer and the PVC substrate can be firmly adhered together, so that the stability of the coating is relatively good. PEG and PVA belong to high polymer materials with good hydrophilic lubrication biocompatibility, so that the problems of hydrophobicity and large friction force on the surface of the PVC catheter can be solved. The preparation method is simple in reaction process, mild in conditionand easy to operate.

Description

technical field [0001] The invention relates to a method for preparing a hydrophilic lubricating coating on the surface of a PVC urinary catheter, belonging to the technical field of polymer materials. Background technique [0002] Due to its excellent mechanical properties, low cytotoxicity, good biocompatibility, low price and many other advantages, PVC catheter is known as one of the most popular varieties in clinical and household disposable catheters. However, due to the hydrophobicity and high friction of its surface, patients often feel uncomfortable during use, and it can also cause catheter-associated urinary tract infection (catheter-associated urinary tract infection, CAUTI). The existing improved technologies include surface coating methods, such as smearing lubricating substances and coating methods, such as silver coatings, antibacterial drug coatings, and hydrogel coatings. Compared with the surface coating method, the coating method has the advantages of bei...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/04A61L29/08A61L29/14
CPCA61L29/041A61L29/085A61L29/14A61L2420/02C08L27/06C08L79/02C08L71/02C08L39/06
Inventor 葛丽芹孙玲莉
Owner SOUTHEAST UNIV
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